Pet-ct

by Conti, Peter S.; Cham, Daniel K., M.D.; Wagner, Henry N., Jr., M.D.

• ISBN13: 9780387208589
• ISBN10: 0387208585
• Format: Hardcover
• Copyright: 2005-01-01
• Publisher: Springer Verlag

Summary

Dr. Peter S. Conti is a Professor of Radiology and the Director of the PET Imaging Science Center at the University of Southern California, and is a Fellow of both the American College of Radiology and American College of Nuclear Physicians. He is a pioneer in the development of the clinical applications of PET and more recently PET-CT. He and one of his fellows, Dr. Daniel Cham, have published this groundbreaking PET-CT case-based book, which reveals how PET-CT can be applied in routine clinical scenarios. Leading authorities in the field examine a wealth of heavily-illustrated original PET-CT cases that showcase both common and uncommon cancers, and the latest PET-CT applications for neurological and cardiovascular disorders. Correlative three-dimensional cross-sectional PET and CT images highlight pathological findings. Each of the clinical applications is accompanied by a concise explanation of the patient history and interpretation of the PET-CT study. Insightful discussions and "pearls and pitfalls" are included to assist in a better understanding of pathology, diagnosis, and imaging approaches. Readers also find important coverage of pathophysiology and technical artifacts. This unique book is ideal for nuclear medicine practitioners, radiologists, and residents, as well as referring clinicians interested in learning more about how this new medical imaging technology can be applied in their patient populations.This unique book is ideal for nuclear medicine practitioners, nuclear medicine residents, and clinicians interested in medical imaging for tumor patients.

Table of Contents

Foreword	vii
Henry N. Wagner, Jr
Preface	ix
Acknowledgments	xi
Contributors	xix
Part I The Fundamentals
Normal Physiology and Variants: A Primer	3	(24)
Daniel K. Cham
Peter S. Conti
Normal Physiology	4	(5)
Nononcologic Pathology	9	(9)
Posttherapeutic Changes	18	(2)
Foreign Body Artifact	20	(3)
Technical Artifacts	23	(4)
Part II Clinical Cases
Adrenal Cancer	27	(3)
Heidi R. Wassef
72-year-old male with previous resection of right adrenal carcinoma being evaluated for recurrent disease	27	(3)
Germ Cell Tumors: Choricocarcinoma and Testicular Cancer	30	(15)
Anabella S. Din
Peter S. Conti
25-year-old male status post left orchiectomy with lesions involving the back, mediastinum, abdomen and the left neck, and elevated beta-HCG and AFP level	30	(5)
26-year-old male status post orchiectomy, chemotherapy and radiotherapy	35	(3)
55-year-old male status post left orchiectomy, pelvic bone resection and left groin lymph node dissection	38	(4)
34-year-old female with a history of metastatic choriocarcinoma confirmed with nodulectomy during a right thoracotomy, presenting with rising HCG	42	(3)
Brain	45	(14)
Sherief Gamie
Peter S. Conti
75-year-old female with suspected temporal glioblastoma for recurrence	45	(1)
73-year-old male who has a history of brain mass and pulmonary carcinoid	46	(2)
81-year-old male who has a history of angiosarcoma	48	(1)
38-year-old female with multiple brain lesions	49	(2)
46-year-old male who has a history of suprasellar mass presenting with left eye blindness	51	(1)
21-year-old male with a seizure disorder	52	(3)
62-year-old female who has a history of glioma	55	(2)
53-year-old female with multiple sclerosis and worsening headache for two months	57	(2)
Breast Cancer	59	(14)
Hossein Jadvar
52-year-old female with a history of breast cancer and fibrous histiocystoma	59	(4)
57-year-old female with a history of left breast cancer, with right pleural and left mid lung metastases	63	(2)
48-year-old female with reported small right axillary mass on ultrasound	65	(2)
56-year-old female who has a history of breast cancer status post left lumpectomy	67	(3)
36-year-old female who has a history of breast cancer and positive neck biopsy	70	(3)
Gynecologic Malignancies: Cervical, Uterine, and Vulvar Cancer	73	(14)
Hossein Jadvar
32-year-old female who has a history of cervical cancer and positive pelvic and abdominal lymphadenopathy	73	(2)
69-year-old female with a history of metastatic cervical cancer in the neck and abdomen	75	(3)
50-year-old female who has a history of cervical cancer with metastatic disease to lung	78	(3)
32-year-old female status post hysterectomy and right oophorectomy for uterine cancer and a left upper lung mass	81	(3)
78-year-old female status post vulvectomy and local radiotheraphyfor vulvar cancer with a subcutaneous mass in the left groin	84	(3)
Colorectal Cancers	87	(14)
Robert W. Henderson
62-year-old male with a history of colon cancer status post chemotheraphy; comparison to positive basal PET study	87	(3)
56-year-old female with a history of colon CA status post chemotherapy and radiofrequency ablation in the liver, now with rising CEA level	90	(3)
59-year-old male status post left hemicolectomy with rising CEA level	93	(2)
51-year-old female with a known metastatic disease for colon carcinoma	95	(3)
42-year-old male with a recent diagnosis of low rectal tumor by biopsy being staged with PET	98	(3)
Cholangiocarcinoma	101	(5)
Heidi R. Wassef
74-year-old male who has a history of extrahepatic cholangiocarcinoma status post Whipple procedure and radioablation therapy now with rising CA 19-9 level	101	(2)
60-year-old male with serosal implantation	103	(3)
Esophageal Carcinoma	106	(9)
Hossein Jadvar
Shahram Bouyadlou
52-year-old male status post esophagectomy for esophageal carcinoma currently evaluated for adrenal adenoma versus metastasis	106	(2)
51-year-old male with a diagnosis of esophageal CA with multiple positive biopsies in the esophagus with two left upper lobe pulmonary nodules	108	(2)
65-year-old male who has a history of esophageal and liver cancer with elevated CEA level	110	(2)
63-year-old female status post esophagectomy with gastric pull-up for esophageal carcinoma	112	(1)
62-year-old male with a history of esophageal cancer status post en bloc esophagectomy and gastric pull-up re-presenting with dysphasia	113	(2)
Gastric Cancer	115	(5)
Hossein Jadvar
Shahram Bouyadlou
64-year-old male with a history of gastric cancer, status post partial gastrectomy with a suspicious lesion in the medial segment of the left hepatic lobe	115	(2)
63-year-old male with a history of gastric cancer with a suspicious lesion in the medial aspect of the inferior portion of the liver	117	(3)
Gastrointestinal Tumors	120	(4)
Heidi R. Wassef
43-year-old male with a history of gastrointestinal stromal tumor	120	(2)
67-year-old male with an ulcerative mass in the post-bulbar duodenum	122	(2)
Head and Neck Cancers	124	(22)
John L. Go
35-year-old female who is status post left modified radical neck dissection with a diagnosis of buccal cavity squamous cell carcinoma	124	(2)
62-year-old male who has a history of squamous cell carcinoma on the face with the most recent MR demonstrating suspicious lesions involving the right lateral pons, right internal auditory canal, and left infratemporal fossa	126	(2)
44-year-old female with a history of nasopharyngeal carcinoma	128	(2)
63-year-old male presents with an enlarged left neck lymph node and a right upper jaw pain	130	(2)
50-year-old male who has a history of oral squamous cell carcinoma status post resection	132	(2)
44-year-old female who had a diagnosis of palate carcinoma with a right infratemporal fossa tumor recurrence on MR	134	(2)
73-year-old male with a history of soft palate surgery status post maxillary sinus surgery	136	(1)
59-year-old male who has a history of right parotid cancer follow by resecton	137	(3)
72-year-old male who has a history of squamous cell carcinoma involving the right parotid gland status post reconstructions	140	(2)
51-year-old male who has a history of tonsillar and submandibular cancer later treated with radiation therapy	142	(4)
Heart Viability	146	(6)
Lalitha Ramanna
55-year-old male with a history of coronary artery disease status post CABG evaluation for heart viability	146	(2)
73-year-old female status post myocardial infarction demonstrating a transmural infarction on a thallium scan and mild to moderate ischemia in the inferoposterior wall	148	(4)
Inflammatory Disease and Infection	152	(3)
Lalitha Ramanna
77-year-old female with a history of ulcerative colitis presenting with significant dilatation in the biliary ducts and colon	152	(3)
Unknown Primary Tumors	155	(4)
Shahram Bouyadlou
Peter S. Conti
38-year-old male who has a history of low-grade fever and episodic night sweats	155	(1)
44-year-old male who has a history of an inflamed left buttock	156	(3)
Liver Cancer	159	(14)
Heidi R. Wassef
67-year-old male who has a history of hepatic ductal cancer	159	(2)
68-year-old male status post liver transplant with suspicious lesions on MR involving the right hepatic dome and right posterior lobe of the liver	161	(3)
59-year-old male status post liver transplant with rising AFP level	164	(3)
58-year-old male with rising AFP level	167	(3)
41-year-old patient with cirrhosis secondary to hepatitis-B and hepatoma being evaluated for potential liver transplant	170	(3)
Lung Tumors	173	(14)
Hossein Jadvar
Sherief Gamie
57-year-old male with known right-sided malignant mesothelioma	173	(1)
55-year-old male who has a history of lung cancer status post left lung biopsy with suspected metastases in the brain and kidney	174	(4)
85-year-old female who has a large mass in the left mid lung and lymphadenopathy in the left hilum, subcarcina, and azygo-esophageal space on a recent chest CT	178	(2)
59-year-old male who has a history of lung cancer with a large mass in the right upper lobe and supraclavicular adenopathy	180	(2)
72-year-old female who has a history of lung cancer positive on bronchoscopy	182	(1)
65-year-old male with known oat cell carcinoma being evaluated for restaging	183	(4)
Hematologic Malignancies: Lymphoma, Leukemia, Multiple Myeloma	187	(17)
Robert W. Henderson
67-year-old male status post left neck biopsy proven to be lymphoma being staged with PET	187	(2)
62-year-old female with several suspicious nodules in the abdominal cavity	189	(2)
64-year-old female with a recent diagnosis of lymphoma being staged with PET	191	(3)
47-year-old male with diagnosis of plasmocytoma with subsequent proton therapy status post decompressive laminectomy	194	(3)
42-year-old male with a history of acute myelocytic leukemia with a left neck lymph node biopsy inconclusive for malignancy	197	(3)
27-year-old female who has a history of Castleman's disease presenting with retroperitoneal adenopathy	200	(2)
58-year-old male presents with several suspicious lesions involving the lung, liver, and spleen	202	(2)
Melanoma	204	(8)
Heidi R. Wassef
69-year-old female with a history of right heel melanoma and right inguinal lymph node involvement	204	(3)
75-year-old male with abnormal CT in the rib, liver and lungs bilaterally	207	(2)
75-year-old female who has Stage-III melanoma status post ipsilateral right inguinal lymph node dissection	209	(3)
Thyroid Carcinoma	212	(8)
Lalitha Ramanna
74-year-old female status post thyroidectomy and radioablation presenting with elevating thyroglobulin level	212	(2)
49-year-old female with a history of papillary thyroid cancer status post radiotherapy and limited neck dissection	214	(1)
62-year-old male with an undifferentiated thyroid carcinoma and esophageal cancer status post radiotherapy and chemotherapy	215	(3)
Remote history of thyroid carcinoma is now being evaluated for soft tissue near the thyroid area suspicious for recurrence	218	(2)
Muscular Skeletal Tumors	220	(14)
Lalitha Ramanna
Sherief Gamie
52-year-old female has a sarcoma in the right thigh	220	(3)
80-year-old female with a leiomyosarcoma	223	(2)
19-year-old male who has a history of a left ankle mass positive for osteosarcoma	225	(5)
43-year-old female has a right thigh angiosarcoma being evaluated for recurrence	230	(2)
25-year-old male who has a history of right knee mass increasing in size	232	(2)
Urinary Malignancies: Renal Cell Carcinoma and Bladder Cancer	234	(7)
Lalitha Ramanna
55-year-old male who has a history of renal cell carcinoma status post left nephrectomy and chemotherapy with a new left renal mass and a nodule in the right lower lung field	234	(2)
76-year-old male with a remote history of laryngeal cancer and a recently diagnosed renal cell carcinoma	236	(1)
82-year-old male status post left nephrectomy and cystectomy for bladder cancer currently being evaluated for a new chest mass	237	(4)
Nerve Tumors	241	(9)
Lalitha Ramanna
63-year-old female who has high-grade malignant peripheral nerve sheath tumor of the right facial nerve with recent fine needle aspiration of a right middle lobe mass positive for malignant spindle cell	241	(2)
48-year-old male status post right ulnar mass resection with primitive neuroectodermal tumor (PNET)	243	(3)
39-year-old male with Schwannoma and multiple left inguinal resections	246	(2)
32-year-old male presents with a left calf tumor	248	(2)
Ovarian Cancer	250	(8)
Hossein Jadvar
73-year-old female status post right gluteal resection from sarcoma who presents with a new right iliac mass	250	(2)
74-year-old female with rising CA-125 leveled status post hysterectomy, bilateral salpingo oophorectomy, and omentectomy and positive pelvic washing	252	(2)
69-year-old female with a history of ovarian cancer currently on Cytoxan therapy	254	(4)
Pancreatic Cancer	258	(6)
Heidi R. Wassef
47-year-old male with a history of pancreatic cancer and liver lesions on CT	258	(2)
82-year-old male with fullness in the pancreatic head on CT and bilateral cavitated pulmonary nodules	260	(1)
64-year-old female with a history of pancreatic cancer ten years ago, status-post Whipple procedure along with a history of thyroidectomy for thyroid cancer eight years ago	261	(3)
Prostate Cancer	264	(3)
Hossein Jadvar
50-year-old male has a prevertebral soft tissue at T-9 on CT and urinary tract symptoms	264	(3)
18F Fluoride Bone Scintigraphy	267	(4)
Peter S. Conti
37-year-old male with a history of osteosarcoma	267	(4)
References	271	(26)
Appendixes
I. PET and PET-CT Reimbursement	285	(11)
Jennifer S. Keppler
II. PET-CT Techniques Applied in Case Studies	296	(1)
James Bading
Peter Shomphe
Index	297