What is included with this book?
The Nature of Complexity and Relevance to Pharmaceutical Sciences | p. 1 |
References | p. 4 |
Further Reading | p. 4 |
Phenomena in Physical and Surface Chemistry | p. 5 |
Chemical Reactions | p. 5 |
Surface and Interfacial Chemistry | p. 6 |
Aggregation | p. 7 |
Adsorption from Solution | p. 10 |
Solid Surface Interaction | p. 13 |
Summary | p. 15 |
References | p. 15 |
Solid State Pharmaceuticals: Solving Complex Problems in Preformulation and Formulation | p. 19 |
Statics | p. 20 |
Solubility, Dissolution, and Release | p. 20 |
Fractal Dimensions and Surface Phenomena | p. 21 |
Monte Carlo Methods in Modeling Drug Release | p. 22 |
Surfaces and Particles | p. 24 |
Dynamics | p. 27 |
Powder Flow and Mixing | p. 27 |
Summary | p. 31 |
References | p. 31 |
Considerations in Monitoring and Controlling Pharmaceutical Manufacturing | p. 37 |
Statistics and Experimental Design | p. 37 |
Sources of Error | p. 37 |
Randomized and Latin Square Designs | p. 38 |
Factorial Design | p. 38 |
Fractional Factorial Design | p. 39 |
Central Composite Design | p. 39 |
Response Surface Maps | p. 39 |
Process Design and Control | p. 40 |
Quality by Design | p. 40 |
Design Space | p. 41 |
Process Analytical Technology | p. 42 |
Risk Assessment and Management | p. 43 |
Summary | p. 44 |
References | p. 44 |
Pharmacokinetics and Pharmacodynamics | p. 47 |
Pharmacokinetics/Toxicokinetics | p. 47 |
Compartmental Modeling | p. 48 |
Fractal Kinetics | p. 49 |
Physiologically Relevant Modeling | p. 50 |
Efficacy/Safety | p. 50 |
Summary | p. 53 |
References | p. 53 |
Impact of Complexity on Population Biology | p. 55 |
Nature of Disease | p. 55 |
Potential for Disease Intervention | p. 56 |
Epidemiological Studies and Adverse Events | p. 57 |
Summary | p. 58 |
References | p. 58 |
Conclusion | p. 61 |
References | p. 66 |
Index | p. 67 |
About the Authors | p. 71 |
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