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ANKE-HILSE MAITLAND-van der ZEE, PhD, is Associate Professor of Pharmacogenetics/Pharmacogenomics at Utrecht University, the Netherlands.
ANN K. DALY, PhD, is Professor of Pharmacogenetics at Newcastle University, UK.
PREFACE vii
CONTRIBUTORS ix
1. Pharmacogenetics: A Historical Perspective 1Ann K. Daly
PART I PHARMACOGENETICS: RELATIONSHIP TO PHARMACOKINETICS AND PHARMACODYNAMICS
2. Pharmacogenetics in Drug Metabolism: Role of Phase I Enzymes 15Vita Dolz!an
3. Pharmacogenetics of Phase II Drug Metabolizing Enzymes 81Ingolf Cascorbi
4. Pharmacogenetics of Drug Transporters 101Henriette E. Meyer zu Schwabedissen, Markus Grube, and Heyo K. Kroemer
5. Pharmacogenetics of Drug Targets 149Ann K. Daly and Maria Arranz
PART II PHARMACOGENETICS: THERAPEUTIC AREAS
6. Cardiovascular Pharmacogenetics 185Bas J. M. Peters, Anthonius de Boer, Tom Schalekamp, Olaf H. Klungel, and Anke-Hilse Maitland-van der Zee
7. Pharmacogenetics in Psychiatry 215Evangelia M. Tsapakis, Sarah Curran, Ruth I. Ohlsen, Nora S. Vyas, Katherine J. Aitchison, and Ann K. Daly
8. Pharmacogenetics in Cancer 251Sharon Marsh
9. Pharmacogenetics of Asthma and COPD 271Ellen S. Koster, Jan A. M. Raaijmakers, Anke-Hilse Maitland-van der Zee, and Gerard H. Koppelman
10. Pharmacogenetics of Adverse Drug Reactions 295Ann K. Daly, Martin Armstrong, and Munir Pirmohamed
11. Pharmacogenomics of Inflammatory Bowel Diseases 323Alexander Teml, Susanne Karner, Elke Schaeffeler, and Matthias Schwab
12. Pharmacogenetics of Pain Medication 353Jo¨rn Lo¨tsch
PART III PHARMACOGENETICS: IMPLEMENTATION IN CLINICAL PRACTICE
13. Ethical and Social Issues in Pharmacogenomics Testing 377Susanne Vijverberg, Toine Pieters, and Martina Cornel
PART IV DEVELOPMENTS IN PHARMACOGENETIC RESEARCH
14. High-Throughput Genotyping Technologies for Pharmacogenetics 403Beatriz Sobrino and Angel Carracedo
15. Developments in Analyses in Pharmacogenetic Datasets 415Alison A. Motsinger-Reif
PART V PHARMACOGENETICS: INDUSTRY AND REGULATORY AFFAIRS
16. Applications of Pharmacogenetics in Pharmaceutical Research and Development 439Daniel K. Burns and Scott S. Sundseth
17. Role of Pharmacogenetics in Registration Processes 461Myong-Jin Kim, Issam Zineh, Shiew-Mei Huang, and Lawrence J. Lesko
PART VI CONCLUSIONS
18. Pharmacogenetics: Possibilities and Pitfalls 479Anke-Hilse Maitland-van der Zee and Ann K. Daly
INDEX 485
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