Pharmacogenetics of Psychotropic Drugs

by Edited by Bernard Lerer

• ISBN13: 9780521189613
• ISBN10: 0521189616
• Edition: Revised
• Format: Paperback
• Copyright: 2011-04-28
• Publisher: Cambridge University Press

Summary

This book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs, reviews advances in the field, and describes the findings that have already emerged. Coverage extends to antipsychotics, antidepressants and mood stabilizing, cognitive-enhancing and anxiolytic drugs. The volume also examines the interface of pharmacogenetics with substance dependence and brain imaging, and considers its impact on the biotechnology and pharmaceutical industries. This book defines the young field of pharmacogenetics as it applies to psychotropic drugs, and is therefore an essential reference for all clinicians and researchers involved.

Table of Contents

Introduction:

Genes and psychopharmacology: exploring the interface

Clinical Background and Research Design:

From pharmacogenetics to pharmacogenomics of psychotropic drug response

Neuropsychopharmacology: the interface between genes and psychiatric nosology

Methodological issues in psychopharmacogenetics

Statistical approaches in psychopharmacogenetics

Molecular Background:

The psychopharmacogenetic-neurodevelopmental interface in serotonergic gene pathways

RNA processing regulation and interindividual variation

Pharmacokinetics:

Pharmacogenetics of psychotropic drug metabolism Vural Ozdemir, Angela

Pharmacogenetics of chiral psychotropic drugs Pierre Baumann

Specific Psychotropic Drugs and Disorders:

Clozapine response and genetic variation in neurotransmitter receptor targets

Genetic factors underlying drug-induced tardive dyskinesia Ronnen

Functional gene-linked polymorphic regions in pharmacogenetics

Alternative phenotypes and the pharmacogenetics of mood and anxiety disorders

Pharmacogenetics of anxiolytic drugs and the GABA-benzodiazepine receptor complex

Genetic factors and long-term prophylaxis in bipolar disorder

Genetic influences on responsiveness to anticonvulsant drugs

Apolipoprotein E as a marker in the treatment of Alzheimer's disease

Genetic variation and drug dependence risk factors

Pharmacogenetics and Brain Imaging:

Brain imaging and pharmacogenetics in Alzheimer's disease and schizophrenia

Industry perspectives:

Pharmacogenetics in psychotropic drug discovery and development

High-throughput single nucleotide polymorphism genotyping

Index

Table of Contents provided by Publisher. All Rights Reserved.