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9780763815271

Pharmacology for Technicians

by ;
  • ISBN13:

    9780763815271

  • ISBN10:

    0763815276

  • Edition: 2nd
  • Format: Paperback
  • Copyright: 2001-12-01
  • Publisher: Emc Pub
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Table of Contents

Preface xi
UNIT 1 THE SCIENCE OF PHARMACOLOGY 1(54)
The Evolution of Medicinal Drugs
3(16)
The History of Medicinal Drugs
3(3)
Early Remedies
3(1)
Drugs in the Middle Ages
4(1)
Drugs in the Modern Age
5(1)
American Pharmacology
5(1)
Twentieth Century Pharmacology
5(1)
Present-Day Pharmacology Practice
6(2)
The Pharmacist and Pharmacy Technician
7(1)
Medicinal Drugs
7(1)
Drug Origins and Sources
8(1)
Drug Names and Classifications
8(1)
Drug Legislation and Regulation
8(2)
The Food and Drug Administration (FDA)
9(1)
Controlled Substances Act
9(1)
Drug Testing and Approval
10(3)
Clinical Trials
11(1)
The FDA Approval Process
11(1)
Post-marketing Surveillance
12(1)
Generic Drugs
12(1)
FDA Food Health Claims
13(1)
Chapter Summary
14(1)
Chapter Review
15(4)
Introduction to Pharmacology
19(14)
Receptors
19(1)
Mechanisms of Drug Action
20(1)
Pharmacokinetics
20(5)
Pharmacokinetics Processes
20(1)
Absorption
21(1)
Distribution
22(1)
Metabolisms
22(1)
Elimination
23(1)
Important Pharmacokinetic Parameters
23(2)
Pharmacokinetic Modeling
25(1)
Drug Effects
25(3)
Beneficial Responses
26(1)
Harmful Responses
26(1)
Allergic Responses
26(1)
Drug Dependence, Addiction, Abuse, and Tolerance
26(1)
Drug Interactions
27(1)
Chapter Summary
28(1)
Chapter Review
29(4)
Administration of Pharmacologic Agents
33(22)
The Drug Prescription
33(2)
Five ``Rights'' for Correct Drug Administration
35(1)
Dosage Forms and Routes of Administration
36(3)
Oral routes
36(2)
Parenteral Routes
38(1)
Topical Routes
38(1)
Factors that Influence Drug Effects
39(5)
Special Considerations in Elderly Patients
39(1)
Changes in Physiologic Function
40(1)
Altered Drug Responses
41(2)
Special Considerations in Pediatric Patients
43(1)
Immunization
43(1)
Teaching Patients to Manage Their Medications
44(1)
Natural Chemicals that Affect Drug Action and Response
45(5)
Histamine
45(1)
The Allergic Response
46(1)
Allergic Diseases
47(1)
Drug Therapy for Allergies
48(1)
Prostaglandins
48(1)
Endocrine System Actions
48(1)
Cardiovascular System Actions
48(1)
Gastrointestinal System Actions
49(1)
Pulmonary System Actions
49(1)
Inflammatory Actions
49(1)
Bradykinin
49(1)
Chapter Summary
50(2)
Chapter Review
52(3)
UNIT 2 ANTI-INFECTIVES AND DRUGS FOR THE COMMON COLD 55(60)
Antibiotics
57(26)
Fighting Bacterial Infections
57(3)
Types of Bacteria
57(1)
Symptoms of Bacterial Infections
58(1)
Antibiotic Treatment and Action
59(1)
Antibiotic Side Effects and Dispensing Issues
59(1)
Antimicrobial Resistance
60(1)
Classes of Antibiotics
60(10)
Sulfonamides
61(1)
Thereapeutic Uses of Sulfonamides
61(1)
Sulfonamides' Side Effects and Dispensing Issues
61(1)
Penicillins
62(1)
Therapeutic Uses of Penicillins
62(1)
Penicillins' side Effects and Dispensing Issues
63(1)
Resistant Penicillins
63(1)
Cephalosporins
63(2)
Therapeutic Uses of Cephalosporins
65(1)
Cephalosporins' Side Effects and Dispensing Issues
65(1)
Structurally Related Drugs
65(1)
Tetracyclines
66(1)
Therapeutic Uses of Tetracyclines
66(1)
Tetracyclines' Side Effects and Dispensing Issues
66(1)
Macrolides
67(1)
Therapeutic Uses of Macrolides
67(1)
Macrolides' Side Effects and Dispensing Issues
67(1)
Quinolones
68(1)
Therapeutic Uses of Quinolones
69(1)
Quionolones' Side Effects and Dispensing Issues
69(1)
Streptogrammins
69(1)
Aminoglycosides
69(1)
Miscellaneous Antibiotics
70(3)
Vancocin (Vancomycin)
70(1)
Chloromycetin (Chloramphenicol)
71(1)
Cleocin (Clindamycin)
71(1)
Flagyl (Metronodazole)
71(1)
Pentam and NabuPent (Pentamidine)
72(1)
Chapter Summary
73(4)
Drugs Summary
77(2)
Chapter Review
79(4)
Antivirals, Antiretrovirals, and Antifungals
83(20)
Viruses and Their Characteristics
83(5)
Stages of Viral Infection
83(1)
Viral Classification
84(1)
Viral Duration and Severity
84(1)
Viral Infection
85(1)
Latent Viruses
85(1)
Virus and Cell Interaction
85(1)
Vaccination
85(1)
Antivirals
86(1)
Systemic Agents
87(1)
Ophthalmic Agents
88(1)
Inhalation Agent
88(1)
Antiretrovirals
88(5)
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
88(2)
Non-Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
90(1)
Protease Inhibitors (PIs)
91(1)
Responding to Exposure to HIV
92(1)
Combining Antiretrovirals
92(1)
Fungi and Their Characteristics
93(4)
Fungal diseases
93(1)
Antifungals
93(4)
Chapter Summary
97(2)
Drug Summary
99(1)
Chapter Review
100(3)
Antihistamines, Decongestants, Antitussives, ad Expectorants
103(12)
Antihistamines
103(2)
Therapeutic Uses of Antihistamines
103(1)
Antihistamines' Side Effects and Dispensing Issues
104(1)
Decongestants
105(2)
Therapeutic Uses of Decongestants
106(1)
Decongestants' Side Effects and Dispensing Issues
106(1)
Antitussives
107(2)
Therapeutic Uses of Antitussives
108(1)
Antitussives' Side Effects and Dispensing Issues
108(1)
Expectorants
109(1)
Chapter Summary
110(1)
Drug Summary
111(1)
Chapter Review
112(3)
UNIT 3 NARCOTIC PAIN RELIVERS AND OTHER NERVOUS SYSTEM DRUGS 115(76)
Anesthetic Analgesics, and Narcotics
117(28)
The Nervous System
117(2)
The Central Nervous System
117(1)
The Peripheral Nervous System
118(1)
The Autonomic Nervous System
118(1)
The Somatic Nervous System
118(1)
Major Neurotransmitters
118(1)
Drug Effects on the Nervous System
119(1)
Anethesia
119(8)
General Anesthetics
120(1)
Preanesthetic Medications
121(1)
Inhalant Anesthetics
121(1)
Malignant Hyperthermia
122(1)
Injectable Anesthetics
123(1)
Antagonists
124(1)
Neuromuscular Blocking Agents
124(1)
Agents to Reverse Neuromuscular Blocking Agents
124(1)
Local Anesthetics
125(2)
Pain Management
127(6)
Narcotics and Opiates
129(1)
Addiction and Dependence
130(1)
Combination Drugs for Managing Pain
131(1)
Narcotic Analgesics
131(2)
Migraine Headaches
133(4)
Selective 5-HT Receptor Agents
135(1)
Ergot Preparations
136(1)
Antiemetic Agents
136(1)
Opioid Analgesics
136(1)
Other Anti-Migraine Agents
136(1)
Chapter Summary
137(2)
Drug Summary
139(2)
Chapter Review
141(4)
Antidepressants, Antipsychotics, and Antianxiety Agents
145(24)
Antidepressants
145(6)
Selective Serotonin Reuptake Inhibitors (SSRIs)
146(1)
Tricyclic Antidepressants (TCAs)
147(1)
Monoamine Oxidase Inhibitors (MAOIs)
148(1)
Other Antidepressants
149(1)
Drugs Uses in Bipolar Disorders
149(1)
Lithium and Its Compounds (Lithonate, Eskalith, Lithobid, Lithotabs)
150(1)
Other Bipolar Drugs
151(1)
Antipsychotics
151(2)
Antipsychotics' Side Effects
152(1)
Drugs that Minimize the Side Effects of Antipsychotics
153(1)
Antipsychotics' Dispensing Issues
153(1)
Antianxiety Agents
153(6)
Panic Disorders
155(1)
Pahtophysiology
155(1)
Treatment
156(1)
Sleep Disorders
156(1)
Stages of Sleep
156(1)
Types of Insomnia
157(1)
Treating Insomnia
157(2)
Alchoholism
159(3)
Alchol's Effects on Metabolism and Excretion
159(1)
Alcohol Antagonists
160(2)
Chapter Summary
162(2)
Drug Summary
164(2)
Chapter Review
166(3)
Anticonvulsants and Drugs to Treat Other CNS Disorders
169(22)
Epilepsy
169(8)
Seizures
169(1)
Partial Seizures
170(1)
Generalized Seizures
170(1)
Status Epilepticus
171(1)
Antiepileptic Drug Therapy
171(6)
Anti-Parkinson Agents
177(3)
Parkinson's Disease
177(1)
Parkinson's Disease Drug Therapy
177(3)
Other CNS Disorders
180(6)
Myasthenia Gravis
181(1)
Attention-Deficit Hyperactivity Disorder and Attention-Deficit Disorder
182(1)
Amyotrophic Lateral Sclerosis (ALS)
183(1)
Multiple Sclerosis (MS)
183(1)
Alzheimer's Disease
184(2)
Chapter Summary
186(1)
Drug Summary
187(1)
Chapter Review
188(3)
UNIT 4 RESPIRATORY, GI, RENAL, AND CARDIAC DRUGS 191(118)
Respiratory Drugs
193(24)
Asthma
193(8)
The Asthmatic Response
194(1)
Goals of Asthma Care and Management of the Disease
194(1)
Asthma Drug Therapy
195(2)
Bronchodilators
197(2)
Xanthime Derivatives
199(1)
Leukotriene Inhibitors
200(1)
Corticosteroids
200(1)
Mast Cell Stabilizers
201(1)
Emphysema and Chronic Bronchitis
201(2)
Other Lung Diseases
203(4)
Pneumonia
203(1)
Cystic Fibrosis (CF)
203(1)
Respiratory Distress Syndrome (RDS)
204(1)
Respiratory Tract Infections
204(1)
Tuberculosis (TB)
205(2)
Smoking Cessation
207(3)
Planning to Stop Smoking
208(1)
Smoking Cessation Drug Therapy
209(1)
Chapter Summary
210(2)
Drug Summary
212(1)
Chapter Review
213(4)
Gastrointestinal Drugs
217(30)
Structure and Function of the Gastrointestinal System
217(1)
Gastrointestinal Diseases
218(8)
Peptic Ulcers
219(1)
Gastric Ulcers
219(1)
Duodenal Ulcers
219(1)
Stress Ulcers
219(1)
Gastrosophageal Reflux Disease (GERD)
219(1)
Drug-Induced Ulcers
220(1)
Pharmacologic Treatment of Gastrointestinal Diseases
220(1)
Antacids
221(2)
Histamine2, Receptor Antagonists
223(1)
Combinations
223(1)
Proton Pump Inhibitors
223(1)
Coating Agents
224(1)
Prostaglandin E Analog
224(1)
Cholinergic Agent
224(1)
Mast Cell Stabilizer
224(1)
Pancreatic Enzyme
224(1)
Immunosuppression
224(1)
Monoclonal Antibody
225(1)
Anti-Inflammatory Drugs
225(1)
Gallstone Dissolution
225(1)
Antiemetic
226(1)
Antidiarrheals
226(1)
Fiber, GI Diseases, and Constipation
227(4)
Fiber Supplementation
228(1)
Gastrointestinal Diseases
228(1)
Diverticular Diseases
228(1)
Hiatal Hernia
229(1)
Irritable Bowel Syndrome (IBS)
229(1)
Hemorrhoids
229(1)
Pharmacologic Treatment of Constipation
229(1)
Emollients/Lubricants
229(1)
Stimulants
230(1)
Bulk-Forming Agents
230(1)
Antiflatulents
231(1)
Bowel Evacuant
231(1)
Antiemetics
231(2)
Obesity
233(3)
Stimulants
235(1)
Lipase Inhibitor
235(1)
Fiber Agents
236(1)
Pharmacologic Treatment of Parasites
236(3)
Platyhelminthes (Flatworms)
237(1)
Flukes and Schistosomiasis
237(1)
Tapeworms
237(1)
Nematodes (Roundworms)
238(1)
Pinworm
238(1)
Whipworm
238(1)
Hookworm
238(1)
Trichinella
238(1)
Stronglyoides
238(1)
Chapter Summary
239(2)
Drug Summary
241(2)
Chapter Review
243(4)
Urinary System Drugs
247(20)
Renal Function and Disease
247(4)
Stages of Renal Disease
248(1)
Causes of Renal Failure
248(1)
Prerenal Events
249(1)
Intrarenal Events
249(1)
Postrenal Events
249(1)
Renal Drug Therapy
249(2)
Drugs for the Urinary Tract
251(4)
Urinary Tract Infections Drug Therapy
252(1)
Benign Prostatic Hypertrophy Drug Therapy
253(2)
Diuretics
255(4)
Chapter Summary
259(1)
Drug Summary
260(1)
Chapter Review
261(6)
Cardiovascular Drugs
267(42)
Heart Disease
267(1)
Antiarrhythmics
268(6)
Normal Cardiac Rhythm
269(1)
Abnormalities in Heart Rate and/or Rhythm
270(1)
Pharmaceutical Treatment of Abnormal Heart Rates and Rhythms
271(1)
Membrane Stabilizing Agents (Class I)
272(1)
Beta Blockers (Class II)
273(1)
Inhibitors of Neurotransmitter Release and Reuptake (Class III)
273(1)
Calcium Channel Blockers (Class IV)
273(1)
Other Agents
274(1)
Drugs for Congestive Heart Failure (CHF)
274(3)
Antiarrhythmics
275(1)
Vasodilators
276(1)
ACE Inhibitors
276(1)
Angiotensin II Antagonists
277(1)
Myocardial Infarction (MI)
277(1)
Causes of a Heart Attack
277(1)
Symptoms of a Heart Attack
277(1)
Myocardial Drug Therapy
278(1)
Angina Pectoris
278(3)
The Symptoms and Risk Factors of Angina Pectoris
278(1)
Antianginal Drugs
279(1)
Nitrates
279(1)
Calcium Channel Blockers
280(1)
Beta Blockers
281(1)
Hpertension
281(6)
Untreated Hypertension
281(1)
Hypertension Therapy
282(1)
Antihypertensive Therapeutics
283(1)
Diruetics
283(2)
Calcium Channel Blockers
285(1)
ACE Inhibitors (Angiotensin Converting Enzyme)
285(1)
Angiotensin II-Receptor Antagonists
285(1)
Beta Blockers
285(1)
CNS Agents
286(1)
Peripheral Acting Agents
286(1)
Vasodilators
286(1)
Combination Drugs
287(1)
Anticoagulants and Antiplatelets
287(4)
Anticoagulant Agents
288(1)
Antiplatelet Agents
289(1)
Glycoprotein Antagonists
289(1)
Fibrinolytic Agents
290(1)
Stroke
291(3)
Causes of a Stroke
291(1)
Types of Stroke
291(1)
Stroke Prevention and Management
292(1)
Antiplatelet and Anticoagulant Agents
292(1)
Anticoagulant and Fibrinolytic Agents
293(1)
Side Effects and Dispensing Issues for TIA and Stroke Prevention Agents
293(1)
Hyperlipidemia
294(5)
Hyperlipidemic Agents
296(1)
HMG-CoA Reductase Inhibitors
296(1)
Fibric Acid Derivatives
297(1)
Bile Acid Sequestrants
298(1)
Other Cholesterol-Lowering Agents
298(1)
Chapter Summary
299(4)
Drug Summary
303(2)
Chapter Review
305(4)
UNIT 5 NONNARCOTIC ANALGESICS, MUSCLE RELAXANTS, HORMONES, AND TOPICALS 309(88)
Muscle Relaxants, Nonnarcotic Analgesics, and Drugs for Arthritis
311(22)
Muscle Relaxants
311(2)
Digestive Therapy for Herniated Disc
313(1)
Nonnarcotic Analgesics
313(4)
Salicylates
314(2)
Antipyretic Analgesic
316(1)
Mixed Analgesics
316(1)
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
316(1)
Drugs for Arthritis and Related Disorders
317(8)
NSAIDs
318(1)
Conventional NSAIDs
319(2)
Cox-2 Inhibitors
321(1)
Other Drugs Used to Treat Rheumatoid Arthritis
321(1)
Disease-Modifying Antirheumatic Drugs
322(1)
Drugs for Gouty Arthritis
323(2)
Chapter Summary
325(3)
Drug Summary
328(1)
Chapter Review
329(4)
Hormones
333(38)
Thyroid Hormones
333(3)
Hypothyroidism
334(1)
Hyperthyroidism
335(1)
Adrenal Sex Hormones and Male Impotence
336(3)
Female Hormones
339(5)
Progestins
339(1)
Estrogen
339(2)
Contraceptives
341(2)
Home Pregnancy Tests
343(1)
Drugs for Bone Diseases
344(2)
Drugs for Sexually Transmitted Diseases
346(4)
Gonorrhea
346(1)
Syphilis
347(1)
Primary-Stage Infection
348(1)
Secondary-Stage Infection
348(1)
Tertiary-Stage Infection
348(1)
Congenital Syphilis
348(1)
Nongonococcal Urethritis (NGU)
348(1)
Lymphogranuloma Venereum
348(1)
Genital Herpes
348(1)
Candidiasis
349(1)
Vaginitis
349(1)
Agents for Sexually Transmitted Diseases
349(1)
Corticosteroids
350(2)
Hypoglycemic Agents
352(7)
Types of Diabetes
353(1)
Lack of Insulin
353(1)
Treating Diabetes
354(1)
Insulin
355(2)
Oral Hypoglycemic Agents
357(1)
First-Generation Sulfonylureas
357(1)
Second-Generation Sulfonylureas
357(1)
Enzyme Inhibitors
357(1)
Biguanide
358(1)
Glitazones
358(1)
Growth Hormone
359(2)
Chapter Summary
361(3)
Drug Summary
364(2)
Chapter Review
366(5)
Topicals, Opthalmics, and Otics
371(26)
Structure and Function of Skin
371(1)
Disorders of the Skin and Agents to Treat Them
372(13)
Disorder of the Sebaceous Glands
372(1)
Pruritus
373(1)
Ultraviolet Radiation and Phototoxicity
373(1)
Allergic and Inflammatory Reactions
374(1)
Viral Infections
374(1)
Fungal Infections
375(1)
Common Agents for Skin Diseases and Disorders
375(1)
Psoriasis
375(1)
Dandruff
375(1)
Acne Vulgaris and Wrinkles
375(2)
Actinic Keratoses
377(1)
Atopic Dermatitis
377(1)
Fungi
377(1)
Other Skin Conditions
377(1)
Antiseptics and Disinfectants
378(2)
Infections and Topical Antibiotics
380(1)
Common Skin Infections
380(1)
Topical Antibiotics
380(1)
Topical Corticosteroids
381(1)
Pediculicides and Scabicides
382(1)
Human Lice
382(2)
Scabies
384(1)
Opthalmics
385(3)
Glaucoma
386(2)
Conjunctivitis
388(1)
Otics
388(2)
Chapter Summary
390(2)
Drug Summary
392(2)
Chapter Review
394(3)
UNIT 6 CHEMOTHERAPY, HERBS, AND MISCELLANEOUS DRUGS 397(60)
Recombinant Drugs and Chemotherapy
399(30)
Recombinant DNA
399(7)
Proteins
399(1)
Recombinant Process for Manufacturing Protein
399(2)
Economic Challenges
401(1)
Recombinant DNA Agents
402(1)
Colony-Stimulating Factors (CSFs)
402(2)
Biological-Response Modifiers
404(1)
Human Growth Hormones
404(1)
Fibrinolytic Agent
405(1)
Secretion-Thinning Agent
405(1)
Hematologic Agent
405(1)
Fusion Protein
405(1)
Immune System
406(7)
Immune Responses
406(1)
Humoral Immunity
406(1)
Immunoglobulins
407(1)
IgG
407(1)
IgM
407(1)
IgA
407(1)
IgE
407(1)
IgD
407(1)
Cellular Immunity
407(1)
Lymphocytes
408(2)
Monoclonal Antibody Antirejection Drugs
410(1)
Other Antirejection Drugs
411(1)
Hypersensitivity
411(1)
Type I Reactions
411(1)
Type II Reactions
412(1)
Type III Reactions
412(1)
Type IV Reactions
412(1)
Summary of Body Defenses
412(1)
Neoplastic Disease (Cancer)
413(8)
Agents for Chemotherapy
414(2)
Alkylating Agents
416(1)
Antibiotics
416(1)
Antimetabolites
416(1)
Hormones
416(1)
Nitrogen Mustards
417(1)
Plant Alkaloids
417(1)
Topoisomerase I Inhibitors
417(1)
Miscellaneous Agents
417(1)
Cytoprotective (Rescue) Agents
417(1)
Biologic-Response Modifiers
418(1)
Interferon
418(1)
Interleukin-2
418(1)
Tumor-Necrosis Factor
418(1)
Colony-Stimulating Factors
418(1)
Monoclonal Antibodies
419(1)
Pain
419(1)
Oral Complications
419(1)
Extravasation of Chemotherapeutic Agents
420(1)
Chapter Summary
421(2)
Drug Summary
423(2)
Chapter Review
425(4)
Vitamins, Nutritional Supplements, Natural Supplements, Antidotes, and CODE Blue Emergencies
429(28)
Total Parenteral Nutrition
429(5)
Malnutrition
430(1)
Indications for Total Parenteral Nutrition
431(1)
Complications of Parenteral Nutrition
431(1)
Preparing Total Parenteral Nutrition Solutions
432(2)
Vitamins, Fluid, Levels, and Electrolytes
434(5)
Vitamins
434(1)
Fat-Soluble Vitamins
435(1)
Water-Soluble Vitamins
435(1)
Body Fluids
436(1)
Extracellular Volume Deficit
437(1)
Extracellular Volume Excess
437(1)
Therapy
437(1)
Electrolytes
438(1)
Sodium (Na+)
438(1)
Potassium (K+)
438(1)
Calcium (Ca++)
438(1)
Chloride (Cl-)
439(1)
Hydrogen Ions (H+)
439(1)
Natural Supplements
439(3)
Natural Supplement Safety
439(2)
Most-commonly Used Natural Supplements
441(1)
Poisons and Antidotes
442(4)
Common Routes of Poisoning
443(1)
Supportive Therapy
443(1)
Gastric Lavage
443(1)
Pharmacologic Antagonists (Antidotes)
444(1)
Antivenoms
445(1)
Supportive Drugs
445(1)
Clinically Significant Drug-Food Interactions
445(1)
CODE Blue Emergencies
446(4)
Agents for Cardiac Emergencies
447(1)
Cardiac Stimulation
447(1)
Hypotension
448(1)
Bradycardia
449(1)
Esophageal Bleeding
449(1)
Cerebrovascular Accident
449(1)
Miscellaneous Agent
449(1)
The Blue Alert Cart
449(1)
Chapter Summary
450(2)
Drug Summary
452(2)
Chapter Review
454(3)
Appendix A Equivalent Measures and Conversions 457(2)
Appendix B Abbreviations 459(2)
Appendix C Lab Values 461(2)
Index 463

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