Pharmacotherapy of Heart Failure

by Gupta, S. K.; Singal, Pawan K.; Agrawal

• ISBN13: 9781904798248
• ISBN10: 1904798241
• Format: Hardcover
• Copyright: 2005-06-30
• Publisher: Anshan

Summary

Heart failure has been traditionally explained as a reduction in cardiac pumping capacity, caused by problems in the blood. Till now the therapy prescribed has been symptomatic, involving the use of diuretics, muscular stimulation and blood vessel relaxants. But recent research has focussed on the circumstances leading up to heart failure, which includes abnormal hemodynamics, atherosclerosis, dietary and nutritional anomalies, obesity, immunity and other metabolic disorders. This book brings together such research in one volume, including molecular and cellular aspects of heart failure and its pathophysiology. It is a significant contribution to the understanding and prevention of heart failure, and will be welcomed by cardiologists, pharmacologists, biochemists, and all those who practice and research the subject. The contributors from around the world include Australia, Brazil, Canada, Denmark, India, and USA.

Table of Contents

Preface	v
Beta-Blockers in Heart Failure	1	(15)
Wagner C. Padua Filho
Cristiane Andrade Yunes
Pathophysiology and Treatment of Heart Failure	16	(22)
Rajat Sethi
Harjot K. Saini
Vijayan Elimban
Naranjan S. Dhalla
Rat Models of Chronic Heart Failure	38	(18)
Vincent Chan
Lindsay Brown
Flavonoids: Promising Cardioprotective Agents	56	(16)
S.K. Gupta
M. Nandave
S.K. Ojha
R. Mittal
D.S. Arya
Role of Methylglyoxal in Essential Hypertension	72	(17)
Sudesh Vasdev
Vicki Gill
Linda Longerich
Identification and Regulation of LOX-1, a Receptor for Ox-LDL: Implications in atherogenesis and myocardial ischemia	89	(6)
J.L. Mehta
Paul L. Hermonat
Dayuan Li
Luis Garza
Guiseppe Novelli
Digoxin, Potassium and Myocardial Na, K-ATPase in Heart Failure	95	(7)
Keld Kjeldsen
Recent Trends in Antiplatelet Therapy for Acute Coronary Syndromes: Glycoprotein IIb/IIIa receptor antagonists	102	(21)
Hetal D. Shah
Keyur Parikh
Ramesh K. Goyal
Fish Oil Therapy and Heart Disease: The significance of genetic factors	123	(17)
Sukhinder Kaur Cheema
Marion L. Cornish
Pujitha DeSilva
Role of AT, Receptor in Enhanced Expression of Gi Proteins in L-NAME Hypertensive Rats	140	(15)
Shehla Hashmin
Madhu B. Anand-Srivastava
Endothelial Dysfunction Reversal in Cardiovascular Disease: Therapeutic Potential	155	(8)
P. Usha Rani
MUR Naidu
Molecular Basis of Acetylcholine-induced Inhibition of Protein Phosphorylation by cAMP-Increasing Agents in Cardiomyocytes: Evidence in favor of activation of protein phosphatase	163	(27)
Ramesh C. Gupta
Molecular Editing of Heart Failure	190	(6)
K. G. Nair
Potential Role of Calmodulin-dependent Cyclic Nucleotide Phosphodiesterase in Ischemia-reperfused Rat Heart	196	(17)
Rajendra K. Sharma
Cyclooxygenase Inhibitors in the Reduction of Hypercholesterolemic Atherosclerosis	213	(7)
Kailash Prasad
Paul Lee
Nutraceuticals: New Approach in Therapy of Cardiovascular Disorders	220	(13)
D.S. Arya
S.K. Ojha
M. Nandave
R. Mittal
S. K. Gupta
Transdermal Drug Delivery Systems for Cardioactive Drugs	233	(8)
S.S. Agrawal
Alcohol and Heart	241	(9)
Ambuj Roy
Rakesh Yadav
Balram Bhargava
Intimal Hyperplasia after Balloon Catheter Induced Carotid Artery Injury in Zucker Rats: Effects of peroxisome proliferator activator receptor ligands α and γ	250	(15)
S.N. Murthy
Vivian A. Fonseca
Dennis B. McNamara
Index	265