Phase II Conjugation Enzymes and Transport Systems

by Sies; Packer

• ISBN13: 9780121828059
• ISBN10: 0121828050
• Edition: 1st
• Format: Hardcover
• Copyright: 2005-11-28
• Publisher: Elsevier Science

Summary

This volume on conjugation enzymes and transporters serves to bring together current methods and concepts in an interesting, important and rapidly developing field of cell and systems biology. It focuses on the so-called Phase II enzymes of drug metabolism (xenobiotics), which has important ramifications for endogenous metabolism and nutrition. Also included are aspects on Phase III, transport systems. This volume of Methods in Enzymology presents current knowledge and methodology on glucuronidation, sulfation, acetylation, and transport systems in this field of research. Together with the volumes on Quinones and Quinone Enzymes (volumes 378 and 382), and on Glutathione Transferases and gamma-Glutamyl Transpeptidases (volume 401), the state of knowledge on proteomics and metabolomics of many pathways of (waste) product elimination, enzyme protein induction and gene regulation and feedback control is provided. This volume will help stimulate future investigations and speed the advance of knowledge in systems biology. *A laboratory standard for more than 40 years *Over 400 volumes strong *Also available on ScienceDirect

Table of Contents

Contributors to Volume 400	p. ix
Preface	p. xv
Volumes in Series	p. xvii
UDP-Glucuronosyltransferases: Gene Structures of UGT1 and UGT2 Families	p. 1
Identification and Characterization of Functional Hepatocyte Nuclear Factor 1-Binding Sites in UDP-Glucuronosyltransferase Genes	p. 22
Substrate Specificity of Human Hepatic UDP-Glucuronosyltransferaes	p. 46
UDP-Glucuronosyltransferase 1A6: Structural, Functional, and Regulatory Aspects	p. 57
The Role of Ah Receptor in Induction of Human UDP-Glucuronosyltransferase 1A1	p. 75
Regulation of the Human UGT1A1 Gene by Nuclear Receptors Constitutive Active/Androstane Receptor, Pregnane X Receptor, and Glucocorticoid Receptor	p. 92
Isoform-Selective Probe Substrates for In Vitro Studies of Human UDP-Glucuronosyltransferases	p. 104
Structure of UDP-Glucuronosyltransferases in Membranes	p. 116
Human SULT1A Genes: Cloing and Activity Assays of the SULT1A Promoters	p. 147
Vitamin D Receptor Regulation of the Steroid/Bile Acid Sulfotransferase SULT2A1	p. 165
Screening and Characterizing Human NAT2 Variants	p. 192
Inactivation of Human Arylamine N-Acetyltransferase 1 by Hydrogen Peroxide and Peroxynitrite	p. 215
Sulfotransferases and Acetyltransferases in Mutagenicity Testing: Technical Aspects	p. 230
A Comparative Molecular Field Analysis-Based Approach to Prediction of Sulfotransferase Catalytic Specificity	p. 249
Glucuronidase Deconjugation in Inflammation	p. 263
Three-Dimensional Structures of Sulfatases	p. 273
Estrogen Sulfatase	p. 293
Analysis for Localization of Steroid Sulfatase in Human Tissues	p. 303
Metabolism of Phytoestrogen Conjugates	p. 316
Sulfation and Glucuronidation of Phenols: Implications in Coenzyme Q Metabolism	p. 342
Synthesis of Bile Acid Coenzyme A Thioesters in the Amino Acid Conjugation of Bile Acids	p. 360
Bile Acid Coenzyme A: Amino Acid N-Acyltransferase in the Amino Acid Conjugation of Bile Acids	p. 374
Multidrug Resistance Protein 1-Mediated Export of Glutathione and Glutathione Disulphide from Brain Astrocytes	p. 395
The Genetics of ATP-Binding Cassette Transporters	p. 409
Functional Analysis of Detergent-solubilized and Membrane-Reconstituted ATP-Binding Cassette Transporters	p. 429
Yeast ATP-Binding Cassette Transporters: Cellular Cleaning Pumps	p. 460
High-Speed Screening of Human ATP-Binding Cassette Transporter Function and Genetic Polymorphisms: New Strategies in Pharmacogenomics	p. 485
Coordinate Transcriptional Regulation of Transport and Metabolism	p. 511
Uptake and Efflux Transporters for Conjugates in Human Hepatocytes	p. 531
Biliary Transport Systems: Short-Term Regulation	p. 542
Inborn Errors of Biliary Canalicular Transport Systems	p. 558
Epoxide Hydrolases: Structure, Function, Mechanism, and Assay	p. 569
Pregnane X Receptor-Mediated Transcription	p. 588
Animal Models of Xenobiotic Receptors in Drug Metabolism and Diseases	p. 598
Cancer and Molecular Biomarkers of Phase 2	p. 618
Author Index	p. 629
Subject Index	p. 683
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