Pheochromocytoma : Pathophysiology and Clinical Management

by Lehnert, Hendrik

• ISBN13: 9783805576246
• ISBN10: 3805576242
• Edition: 1st
• Format: Hardcover
• Copyright: 2003-09-01
• Publisher: KARGER, S. PUBLISHERS INC

Summary

Pheochromocytomas are rare, mostly benign tumors of the adrenal medulla whose symptoms are caused by a tumor-induced secretion of catecholamines. This book provides an overview of current knowledge on the clinical situation, diagnosis and therapy of the disease as well as an extensive discussion of novel aspects in the molecular basis of this disease such as the recognition of new tools in molecular biology. The endocrine diagnosis is based on precise knowledge of tumor metabolism of catecholamines and their metabolites and today comprises laboratory methods with a high sensitivity and specificity. As approximately one quarter of these tumors arise in the context of a familial disease, such as multiple endocrine neoplasia type 2, von Hippel-Lindau syndrome, neurofibromatosis type 1 or familial paragangliomas, the genetic diagnosis is becoming increasingly relevant. Equally indispensable are imaging methods such as 123I-MIBG scintigraphy or octreotide scintigraphy, whi

Table of Contents

Foreword	vii
Grossman, A.B. (London)
Preface	ix
Lehnert, H. (Magdeburg)
Principles of Catecholamine Biosynthesis, Metabolism and Release	1	(25)
Schulz, C.; Eisenhofer, G.; Lehnert, H. (Magdeburg)
Pathogenesis of Pheochromocytoma	26	(19)
Isobe, K.; Takekoshi, K.; Kawakami, Y.; Nakai, T. (Tsukuba)
The Genetic Basis of Pheochromocytoma	45	(16)
Gimm, O.; Koch, C.A.; Januszewicz, A.; Opocher, G.; Neumann, H.P.H. (Halle)
The Clinical Presentation (Symptoms and Signs) of Sporadic and Familial Chromaffin Cell Tumours (Phaeochromocytomas and Paragangliomas)	61	(15)
Kaltsas, G.A.; Papadogias, D.; Grossman, A.B. (London)
Biochemical Diagnosis of Pheochromocytoma	76	(31)
Eisenhofer, G. (Bethesda, Md.); Lenders, J.W.M. (Nijmegen); Pacak, K. (Bethesda, Md.)
Diagnostic Imaging of Pheochromocytoma	107	(14)
Pacak, K.; Eisenhofer, G.; Ilias, I. (Bethesda, Md.)
Preoperative and Surgical Therapy in Sporadic and Familial Pheochromocytoma	121	(24)
Brauckhoff, M.; Gimm, O.; Dralle, H. (Halle)
Somatostatin Receptors in Pheochromocytoma	145	(10)
de Herder, W.W.; Hofland, L.J. (Rotterdam)
Malignant Pheochromocytoma	155	(8)
Lehnert, H.; Mundschenk, J. (Magdeburg); Hahn, K. (Munich)
Author Index	163	(1)
Subject Index	164