Physiology and Pathophysiology of Leukocyte Adhesion

by Granger, D. Neil; Schmid-Schonbein, Geert W.

• ISBN13: 9780195081022
• ISBN10: 0195081021
• Format: Hardcover
• Copyright: 1995-01-05
• Publisher: Oxford University Press

Summary

Leukocytes play an integral role in the pathogenesis of different inflammatory disorders. Recent results indicate that leukocytes are also involved in conditions that had not formerly been associated with a cytotoxic effect by leukocytes. In 27 chapters by leading investigators, this book reviews recent research on leukocyte adhesion and microvascular kinetics. Detailed descriptions of adhesive glycoproteins expressed on the surface of leukocytes and endothelial cells are given together with summaries of the current state of leukocyte rheology, kinetics and entrapment in microvessels. Since leukocytes reach all organs, the mechanisms described in this volume may apply to a wide range of cardiovascular disorders. A variety of important inflammatory and circulatory disorders are discussed including cerebral and coronary ischemia, shock, atherogenesis, chronic venous insufficiency, gastric ulcer and diabetic retinopathy. New concepts about the etiology of cardiovascular complications are presented, with emphasis on molecular, cellular, and microvascular mechanisms. The current state of endogenous anti-adhesive and pro-adhesive mediators is summarized, including interventions against leukocyte activation and adhesion.

Table of Contents

Molecular and Cellular Biology of Adhesion Molecules

The Role of B2 Integrins and ICAM-1 in Inflammation

Selectin Family of Adhesion Molecules

Biorheology of Leukocyte Adhesion

The Mechanical Properties of Individual Passive Neutrophils In Vitro

Flow Behavior of Leukocytes in Small Tubes

Biophysical Parameters of Leukocyte Adhesion to Vascular Endothelium

Leukocyte Margination and Deformation in Post-Capillary Venules

Effects of Fluid Shear Stress on Leukocyte Adhesion to Endothelial Cells

Modulation of Leukocyte-Endothelial Cell Adhesion

Inflammatory Mediators, Cytokines, and Leukocyte Adhesion in Post-Capillary Venules

Ultrastructural Basis of Leukocyte Migration Through the Microbascular Membrane

Endothelial Cytoskeletal Regulation of Neutrophil Diapedesis

Modulatin of Leukocyte Rolling In Vivo

Endogenous Anti-Adhesive Molecules

Oxygen Radical-Mediated Leukocyte Adherence

Flow-Dependence of Leukocyte-Endothelial Cell Adhesion in Postcapillary Venules

Leukocyte Dynamics in Regional Circulations

Pathophysiologic Implications of Leukocyte Adhesion

Role of Adherence Molecules in Lung Inflammation

Modulation of Leukocyte Adherence and Emigration During Ischemia and Reproduction

Leukocytes in Capillary Networks

Role of Leukocyte Adherence in Reperfusion-Induced Microvascular Dysfunction and Tissue Injury

Contribution of Adherent Leukocytes to Circulatory Shock

Role of Leukocyte Adhesion in Myocardial Ischemia-Reperfusion Injury

PMN Leukocyte Adhesion in Cerebrovascular Ischemia

Leukocyte Adhesion in Atherogenesis

Chronic Venous Ulceration: A Role for Leukocyte Mediated Injury

Role of Leukocytes in Diabetic Retinopathy

The Potential Role of Blood Leukocyte Interaction in Progression of the Genetic Arterial Hypertensive Syndrome

Role of Neutrophils in the Pathogenesis of Gastric Ulcer

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