The Placenta From Development to Disease

by Kay, Helen; Nelson, D. Michael; Wang, Yuping

• ISBN13: 9781444333664
• ISBN10: 1444333666
• Edition: 1st
• Format: Hardcover
• Copyright: 2011-04-18
• Publisher: Wiley-Blackwell

Summary

Written by internationally recognized experts in the field, The Placenta: From Development to Disease is a clinical guide to identifying and managing problems in pregnancy associated with the placenta. Not only does this useful text detail the normal development of the placenta and fetus, a major component of the book focuses on abnormal placenta development and the resulting threats to the fetus and mother. Enhanced information is available throughout in helpful feature boxes highlighting "Clinical Pearls" and "Research Spotlights." The Placenta: From Development to Disease is the only clinical guide to this key organ.

Author Biography

Helen Kay, MD, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA

D. Michael Nelson, MD, PhD, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, USA

Yuping Wang, MD, PhD, Departments of Obstetrics and Gynecology, and Molecular and Cellular Physiology, Louisiana State University Health Sciences Center – Shreveport, Shreveport, LA, USA

Table of Contents

List of Contributors

Foreword

Preface

Fetal origins of adult disease/programming

Maternal Undernutrition and Fetal Programming: Role of the Placenta

Cardiovascular Health and Maternal Placental Syndromes

Placental development, physiology and immunology

Development and Anatomy of the Human Placenta

Immunologic Aspects of Pregnancy

Vascular Development in the Placenta

Hypoxia and the Placenta

Placental Metabolism

Placental Hormones: Physiology, Disease and Prenatal Diagnosis

Placental Transfer in Health and Disease

Placental Fat Trafficking

MaternalâÇôFetal Cell Trafficking and Microchimerism

Imprinting in the Human Placenta

Placental membranes and amniotic fluid retention

Examination of the placenta, membranes, cord

Examination of the Placenta, Membranes and Cord

The Umbilical Cord

Ultrasound Imaging and Doppler Studies of the Placenta

Magnetic Resonance Imaging and Positron Emission Tomography of the Placenta

Chorionic Villous Sampling and Amniocentesis

Cordocentesis and Fetoscopy

Research techniques to study the placenta

Trophoblast Isolation and Culture

Isolation and Culture of Human Umbilical Cord Vein Endothelial Cells

Perfusion Technique for Studying the Placenta Cotyledon

ThreeâÇôDimensional Culture Modeling of the Placenta

The Use of Ultrasound Contrast Agents in Placental Imaging

Microscopy and the Placenta

Proteomics & the Placenta

Stable Isotope Methodologies for the Study of Transport and Metabolism In Vivo

Medical diseases and complications

The Role of the Placenta in Autoimmune Disease and Early Pregnancy Loss

The Placenta in Preterm Prelabor Rupture of Membranes and Preterm Labor

Diabetes and the Placenta

Placental Origins of Intrauterine Growth Restriction

The Placenta in Preeclampsia

Thrombophilia and the Placenta

Infections in the Placenta

Aneuploidy and Polyploidy

Gestational Trophoblastic Disease and Placental Tumors

Multiple Gestation and TwinâÇôTwin Transfusion syndrome

Previa and Abruption

The Placenta as a Functional Barrier to Fetal Drug Exposure

Placental Drug Transport

Future clinical applications

Umbilical Cord Blood Banking

Stem Cells from the Placenta

Fetal DNA, RNA and prenatal diagnosis

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