Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook

by Edited by Paolo Gresele , Valentin Fuster , Jose A. Lopez , Clive P. Page , Jos Vermylen

• ISBN13: 9780521881159
• ISBN10: 0521881153
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-01-14
• Publisher: Cambridge University Press

Summary

A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering Platelet Physiology, Bleeding Disorders, Thrombotic Disorders and Antithrombotic Therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

Table of Contents

List of contributors	p. v
Preface	p. ix
Glossary	p. xi
The structure and production of blood platelets	p. 1
Platelet immunology: structure, functions, and polymorphisms of membrane glycoproteins	p. 21
Mechanisms of platelet activation	p. 37
Platelet priming	p. 53
Platelets and coagulation	p. 79
Vessel wall-derived substances affecting platelets	p. 92
Platelet-leukocyte-endothelium cross talk	p. 106
Laboratory investigation of platelets	p. 124
Clinical approach to the bleeding patient	p. 147
Thrombocytopenia	p. 155
Reactive and clonal thrombocytosis	p. 186
Congenital disorders of platelet function	p. 201
Acquired disorders of platelet function	p. 225
Platelet transfusion therapy	p. 242
Clinical approach to the patient with thrombosis	p. 261
Pathophysiology of arterial thrombosis	p. 279
Platelets and atherosclerosis	p. 293
Platelets in other thrombotic conditions	p. 308
Platelets in respiratory disorders and inflammatory conditions	p. 323
Platelet pharmacology	p. 341
Antiplatelet therapy versus other antithrombotic strategies	p. 367
Laboratory monitoring of antiplatelet therapy	p. 386
Antiplatelet therapies in cardiology	p. 407
Antithrombotic therapy in cerebrovascular disease	p. 437
Antiplatelet treatment in peripheral arterial disease	p. 458
Antiplatelet treatment of venous thromboembolism	p. 471
Index	p. 483
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