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9780521292047

Polycyclic Aromatic Hydrocarbons: Chemistry and Carcinogenicity

by
  • ISBN13:

    9780521292047

  • ISBN10:

    0521292042

  • Format: Paperback
  • Copyright: 2011-06-16
  • Publisher: Cambridge University Press

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Summary

Polycyclic aromatic hydrocarbons, many of which have been identified as potent human carcinogens, occur widely in the environment as a result of incomplete combustion of fossil fuels and other organic matter. Major sources of emissions arise from wood and coal burning, automobiles, heat and power plants, and refuse burning. Their widespread occurrence in the air and in food and water underlines the importance of understanding their role as causes of human cancer. This 1991 volume was the first to review the chemical properties of these carcinogens and to relate their carcinogenic activity to their metabolic by-products within the body. The emphasis throughout is on those recent findings, newer methods and techniques which helped to illuminate the process of carcinogenesis. The volume is suitable for anyone with a professional interest in the chemistry and metabolism of polycyclic aromatic hydrocarbons, environmental chemistry and chemical carcinogenesis.

Table of Contents

Preface
Nomenclature
Environmental occurrence and cancer
Structure-activity relationships
Metabolic activation, DNA binding, and mechanisms of carcinogenesis
Molecular properties of polyarenes
Chemical reactivity
General synthetic methods
Alterant tetracyclic polyarenes
Alterant pentacyclic polyarenes
Alternant hexacylic polyarenes
Nonalternant polyarenes
Arene oxides and imines
Dihydrodiols
Diol epoxides
Other oxidized metabolites
Index
Table of Contents provided by Publisher. All Rights Reserved.

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