Polycystic Ovary Syndrome

by Dunaif, Andrea, M.D.; Chang, R. Jeffrey; Franks, Stephen, M.D.; Legro, Richard S., M.D.

• ISBN13: 9781588298317
• ISBN10: 1588298310
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-02-08
• Publisher: Humana Pr Inc

Summary

All four editors of this title are extremely prominent in the field of PCOS. Although they are all U.S.-based, they are internationally renowned. The book includes the latest diagnostic criteria for PCOS, and comprises the most up to date information about the genetic features and pathogenesis of PCOS. The diagnostic criteria for PCOS took shape in 1990 following an NIH conference co-organized by Dr. Dunaif, resulting in her classic volume, Polycystic Ovary Syndrome (1992). That title recommended diagnostic criteria of hyperandrogenism and chronic anovlulation with the exclusion of specific disorder of the ovary, adrenal, and pituitary. These criteria dominated the field but were revised in 2003 by a working group of international experts at a conference in Rotterdam. Since then, it has become increasingly clear over the past several years that PCOS is a complex genetic disease resulting from the interaction of susceptibility genes and environmental factors. This volume critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. Additional familial phenotypes of PCOS and their potential genetic basis are also discussed. In all, this title is comprehensive and replete with the latest in expert recommendations on PCOS. This expert opinion remains critical to guiding practice in PCOS because sufficient data for evidence-based guidelines remains scarce.

Table of Contents

Preface	p. vii
Contributors	p. xi
List of Color Plates	p. xv
Folliculogenesis in Polycystic Ovaries	p. 1
Accounting for the Follicle Population in the Polycystic Ovary	p. 9
What Is the Appropriate Imaging of the Polycystic Ovary	p. 25
Polycystic Ovary Versus Polycystic Ovary Syndrome: A Necessary Distinction	p. 37
Genetic Analyses of Polycystic Ovary Syndrome	p. 51
Fetal Origins of Polycystic Ovary Syndrome	p. 87
Pubertal Precursors of the Polycystic Ovarian Syndrome	p. 107
Variations in the Expression of the Polycystic Ovary Syndrome Phenotype	p. 123
Acquired Polycystic Ovary Syndrome: Epilepsy, Bipolar Disorder, and the Role of Anti-Epileptic Drugs	p. 133
Recommendations for the Early Recognition and Prevention of Polycystic Ovary Syndrome	p. 147
Insulin Action and Secretion in Polycystic Ovary Syndrome	p. 159
Polycystic Ovary Syndrome and the Metabolic Syndrome Long-Term Risks	p. 185
Insulin Sensitizers Targeting Metabolic and Reproductive Consequences in Polycystic Ovary Syndrome	p. 197
Mechanisms and Treatment of Obesity in Polycystic Ovary Syndrome	p. 217
Metabolic and Endocrine Effects of Statins in Polycystic Ovary Syndrome	p. 241
Recommended Therapies for Metabolic Defects in Polycystic Ovary Syndrome	p. 259
Pathogenesis of Hyperandrogenism in Polycystic Ovary Syndrome	p. 281
Recommended Treatment Modalities for Hyperandrogenism	p. 295
Effective Regimens for Ovulation Induction in Polycystic Ovary Syndrome	p. 307
Pregnancy in Polycystic Ovary Syndrome	p. 321
Impact of Diagnostic Criteria: NICHD Versus Rotterdam	p. 333
Subject Index	p. 345
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