Polymer Based Systems on Tissue Engineering, Replacement and Regeneration

by Reis, Rui L.; Cohn, Daniel

• ISBN13: 9781402010019
• ISBN10: 140201001X
• Format: Paperback
• Copyright: 2003-02-01
• Publisher: Kluwer Academic Pub

Summary

Biodegradable, polymer-based systems are playing an increasingly pivotal role in tissue engineering replacement and regeneration. This type of biology-driven materials science is slated to be one of the key research areas of the 21st century. The following aspects are crucial: the development of adequate human cell culture to produce the tissues in adequate polymer scaffold materials; the development of culture technology with which human tissues can be grown ex-vivo in 3D polymer matrices; the development of material technology for producing the degradable, 3D matrices, having mechanical properties similar to natural tissue. In addressing these and similar problems, the book contains chapters on biodegradable polymers, polymeric biomaterials, surface modification for controlling cell-material interactions, scaffold design and processing, biomimetic coatings, biocompatibility evaluation, tissue engineering constructs, cell isolation, characterisation and culture, and controlled release of bioactive agents.

Table of Contents

Contributors	ix
Welcome Addresses
Preface	3	(4)
R. L. Reis
30 Years of R&D in Portugal	7	(6)
C.A.A. Bernardo
Overview on Polymeric Biomaterials and Biodegradable Polymers
Polymeric Biomaterials in Medical Systems	13	(12)
Y. Ikada
Biodegradable Polymers for Orthopaedic Applications	25	(12)
C.M. Agrawal
Polymeric Matrices for Release of Growth Factors, Hormones and Other Bioactive Agents	37	(18)
A. Gallardo
G.A. Abraham
C. Elvira
B. Vazquez
J. San Roman
Novel Systems, Hydrogels and Bone Cements
Membranes and Hydrogels in Reconstructive Surgery	55	(14)
D. Bakos
J. Koller
Key-Properties and Recent Advances in Bone Cements Technology	69	(24)
B. Vazquez
G.A. Abraham
C. Elvira
A. Gallardo
J. San Roman
Soy Protein-Based Systems for Different Tissue Regeneration Applications	93	(20)
C.M. Vaz
L.A. de Graaf
R.L. Reis
A.M. Cunha
Characterization of Polymeric Systems and Scaffolds
In Vitro Testing of Polymeric Scaffolds	113	(12)
C. M. Agrawal
Characterization of Degradable Polymers for Orthopedic Application
Examining Tyrosine-Derived Polycarbonates for Tissue Engineering of Bone	125	(14)
S.D. Abramson
A. Seyda
P. Sidney Sit
J. Kohn
Dynamic Mechanical Analysis in Polymers for Medical Applications	139	(28)
J.F. Mano
R.L. Reis
A.M. Cunha
Surface Modification, Functionalization and Osteoconductivity
Macromolecular Design of New Synthetic Biodegradable Medical Polymers Functional Polyesters and Copolymers with Cell-adhesion Peptide Sequences	167	(16)
F. Rypacek
Surface Treatments and Pre-Calcification Routes to Enhance Cell Adhesion and Proliferation	183	(38)
A.L. Oliveira
I.B. Leonor
C. Elvira
M.C. Azevedo
I. Paskuleva
R.L.Eis
Tissue Engineering and Regeneration of Bone and Cartilage
Bone Tissue Engineering Using Starch Based Scaffolds Obtained by Different Methods	221	(30)
M.E. Gomes
A. Salgado
R.L. Reis
Bone Tissue Engineering by Cell Transplantation	251	(14)
G.N. Bancroft
A.G. Mikos
Cultured Bone on Biomaterial Substrates
A Tissue Engineering Approach to Treat Bone Defects	265	(34)
S.C. Mendes
J.D. de Bruijn
C.A. Van Blitterswijk
Injectable Biodegradable Materials for Orthopaedic Tissue Engineering	299	(14)
J.S. Temenoff
A.G. Mikos
Tissue Engineering of Elastic Cartilage by Using Scaffold/Cell Constructs with Different Physical and Chemical Properties	313	(20)
D. W. Hutmacher
X. Fu
B. K. Tan
J-T. Schantz
Craniofacial Bone Tissue Engineering Using Medical Imaging, Computational Modeling, Rapid Prototyping, Bioresorbable Scaffolds and Bone Marrow Aspirates	333	(24)
D.W. Hutmacher
D. Rohner
V. Yeow
S.T. Lee
A. Brentwood
J-T. Schantz
Tissue Engineering and Regeneration of Other Tissues
Biodegradable Polymers as Scaffolds for Tissue Engineering and as Tissue Regeneration Inducers	357	(14)
Y. Ikada
Scaffolding Arterial Tissue	371	(20)
D. Cohn
G. Marom
Tissue-Engineered Vascular Grafts for Small-Diameter Arterial Replacement	391	(18)
M.J.B. Wissink
J. Feijen
Industrial and Innovation Opportunities
An Exploratory Analysis of the Determinants of Innovation in the Emerging Tissue Engineering Industry	409	(10)
N. Pangarkar
D.W. Hutmacher
Index	419