Polymorphism in Pharmaceutical Solids, Second Edition

by Brittain; Harry G.

• ISBN13: 9781420073218
• ISBN10: 1420073214
• Edition: 2nd
• Format: Hardcover
• Copyright: 2009-07-27
• Publisher: CRC Press

Summary

Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Editionpresents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. Fully updated and expanded, this new edition focuses on pharmaceutical aspects of polymorphism and solvatomorphism, while systematically explaining their thermodynamic and structural origins.Polymorphism of Pharmaceutical Solids, Second Edition now includes:

Author Biography

Harry G. Brittain is Institute Director, Center for Pharmaceutical Physics, Milford, New Jersey, USA. Dr. Brittain's former positions include Vice President for Pharmaceutical Development at Discovery Laboratories, Inc. and Director of Pharmaceutical Development at Ohmeda, Inc. He has also held faculty positions at Ferrum College and Seton Hall University, and has served as Adjunct Professor at Rutgers University and Lehigh University. He has authored more than 300 research publications and book chapters, and has presented numerous invited lectures and short courses in pharmaceutics. Dr. Brittain is Associate Editor for the Journal of Pharmaceutical Sciences and serves on the editorial boards of Pharmaceutical Research and AAPS PharmSciTech. He is also Editor for the book series Profiles of Drug Substances, Excipients, and Related Technology. Dr. Brittain is Fellow of the American Association of Pharmaceutical Scientists and presently serves as Chairman of the United States Pharmacopeia expert committee on Excipient Monograph Content. He is also on the Organic and Pharmaceutical subcommittee of the International Centre for Diffraction data.

Table of Contents

Preface	p. vii
Contributors	p. xi
Thermodynamic and Theoretical Issues
Theory and Principles of Polymorphic Systems	p. 1
Application of the Phase Rule to the Characterization of Polymorphic and Solvatomorphic Systems	p. 24
Computational Methodologies: Toward Crystal Structure and Polymorph Prediction	p. 52
Preparative Methods for Polymorphs and Solvatomorphs
Classical Methods of Preparation of Polymorphs and Alternative Solid Forms	p. 76
Approaches to High-Throughput Physical Form Screening and Discovery	p. 139
Structural Properties of Polymorphs and Solvatomorphs
Structural Aspects of Polymorphism	p. 185
Structural Aspects of Solvatomorphic Systems	p. 233
Pharmaceutical Co-crystals: A New Opportunity in Pharmaceutical Science for a Long-Known but Little-Studied Class of Compounds	p. 282
Characterization Methods for Polymorphs and Solvatomorphs
Thermoanalytical and Crystallographic Methods	p. 318
Vibrational Spectroscopy	p. 347
Solid-State Nuclear Magnetic Resonance Spectroscopy	p. 381
Effects of Polymorphism and Solid-State Solvation on Solubility and Dissolution Rate	p. 436
Interconversion of Polymorphs and Solvatomorphs
Solid-State Phase Transformations	p. 481
Effects of Pharmaceutical Processing on the Solid Form of Drug and Excipient Materials	p. 510
Special Topics Related to Polymorphism and Solvatomorphism
Structural Aspects of Molecular Dissymmetry	p. 560
Amorphous Solids	p. 587
Index	p. 631
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