Postmenopausal Osteoporosis: Hormones & Other Therapies

by Genazzani; Andrea R.

• ISBN13: 9781842143117
• ISBN10: 1842143115
• Format: Hardcover
• Copyright: 2006-01-17
• Publisher: CRC Press

Summary

The book is the first major review of menopause-associated osteoporosis, post WHI. The book has in-depth sections on the pathogenesis, epidemiology, and diagnosis of osteoporosis. The chief focus is on medical prevention and treatment, and includes chapters on hormone replacement therapy, bisphosphonates, selective estrogen receptor modulators (SERMs), vitamin D derivatives, calcium supplements, androgens, and tibolone.

Table of Contents

List of contributors	ix
Preface	xv
Section I: Introduction
Magnitude and impact of osteoporosis and fractures	1	(10)
C. Marcocci
F. Cetani
E. Vignali
A. Pinchera
Impact of osteoporosis on quality of life and quality of life on osteoporosis: rationale and methodology for accurate assessment	11	(6)
W. H. Utian
Section II: Gonadal steroids and the pathogenesis of osteoporosis
Novel signals determining skeletal cell fate and function	17	(6)
E. Canalis
V. Deregowski
R. C. Pereira
E. Gazzerro
Sex steroid hormones and bone formation	23	(8)
R. Civitelli
The effect of sex steroids on osteoclast function	31	(14)
K. Henriksen
N. A. Sims
L. B. Tanko
M. A. Karsdal
Calcium and vitamin D: regulation of mineral homeostasis	45	(10)
D. Goltzman
Section III: Epidemiology
Genetic regulation of bone mass	55	(8)
S. H. Ralston
Bone mineral acquisition during infancy and adolescence	63	(8)
G. Saggese
G. I. Baroncelli
Osteoporosis: influence of life-style	71	(6)
R. Rizzoli
Postmenopausal osteoporosis and dental health	77	(20)
J. Wactawski-Wende
Section IV: Diagnosis
Bone quality	97	(6)
C. E. Bogado
Diagnosis: clinical, hormonal and biochemical evaluation	103	(10)
D. M. Reid
Advanced imaging assessment of bone quality	113	(14)
H. K. Genant
Y. Jiang
Quantitative ultrasonometry of bone in the management of postmenopausal women	127	(14)
P. Hadji
Section V: Pharmacological prevention and treatment
Awareness of osteoporosis and related treatments	141	(4)
A. D. Woolf
Intervention thresholds for osteoporosis	145	(6)
J. A. Kanis
Vitamin D and calcium supplements	151	(20)
R. Nuti
L. Gennari
D. Merlotti
G. Martini
Estrogen dose response in bone density and bone histology	171	(6)
E. Horner
J. Studd
Effects of oral contraceptive preparation on bone health	177	(8)
M. Gambacciani
Hormone replacement therapy	185	(8)
L. B. Tanko
C. Christiansen
New physiologic approach to prevention of postmenopausal osteoporosis	193	(10)
B. Ettinger
J. S. Lee
Selective estrogen receptor modulators	203	(6)
A. Diez-Perez
Bisphosphonates in the management of osteoporosis	209	(10)
S. E. Papapoulos
Phytoestrogens: food or drug?	219	(14)
L. Bacciottini
A. Falchetti
B. Pampaloni
E. Bartolini
A. M. Carossino
M. L. Brandi
Tibolone	233	(6)
M. R. McClung
Understanding the role of aromatizable androgens in bone-sparing	239	(8)
O. Tuncalp
V. Edusa
A. Fadiel
F. Naftolin
Section VI: Specific aspects of selected therapies
Strontium ranelate: a new first-line treatment for patients with postmenopausal osteoporosis	247	(8)
S. Ortolani
Reconciling risks and benefits of hormone replacement therapy in a single outcome: the QALY approach	255	(8)
J. M. Alt
Y. Zollner
J. Ryan
Prevent, treat and maintain: how to optimize the management of postmenopausal osteoporosis	263	(8)
D. Agnusdei
Transdermal hormone therapy: effects on bone	271	(4)
R. E. Nappi
F. Albani
F. Ferdeghini
S. Detaddei
A. Sommacal
A. Verza
A. Ornati
F. Polatti
Progestogens and bone	275	(6)
D. W. Sturdee
Effect of different dose options of continuous combined hormone therapy on bone and bone marker N-terminal propeptide of type I procollagen: results from a long-term study in Finnish postmenopausal women	281	(8)
J. Heikkinen
J. Haapalahti
The use of alendronate in osteoporosis treatment: 10-year experience	289	(14)
M. L. Brandi
Index	303