Potential Health Benefits of Citrus

by Patil, Bhimanagouda S.; Turner, Nancy D.; Miller, Edward G.; Brodbelt, Jennifer S.

• ISBN13: 9780841239579
• ISBN10: 0841239576
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-07-13
• Publisher: American Chemical Society

Summary

During the last 10-20 years, interest in the health-promoting activity of chemicals in fruits and vegetables has increased dramatically. This book will focus on the recent research dealing with the bioactive agents in citrus. The book will cover a wide range of topics including isolation, purification, biological activities in animal and cell models, nutritional significance, and clinical trials. The chapters will mainly focus on citrus flavonoids, limonoids, and polysaccharides with emphasis on the ability of these naturally occurring chemicals to inhibit the development of cancer, heart disease, and obesity. In addition, several chapters will look at mechanism of action including antioxidant activity and effects on phase I and phase II enzymes. While there are multiple positive benefits linking citrus consumption to human health, lack of an understanding of the myths and realities of grapefruit-drug interactions have left some consumers taking certain medications in an ambiguous situation. Several chapters will concentrate on this subject and the role of furocoumarins in inhibiting the activity of drug metabolizing enzymes. The book will differ from the symposium in several key ways. One, it will contain several chapters from authors not presenting at the symposium. Two, with a three session symposium it is highly unlikely that most people will be able to attend all of the sessions. The book will contain all of the basic information presented at the symposium. Three, the book will give the authors a chance to cover details that cannot be considered during a short presentation at a meeting.

Table of Contents

Preface	xi
1. Potential Health Benefits of Citrus: An Overview	1
Bhimanagouda S. Patil, Jennifer S. Brodbelt, Edward G. Miller, and Nancy D. Turner
Isolation and Characterization of Citrus Bioactive Compounds
2. Citrus Bioactive Limonoids and Flavonoids Extraction by Supercritical Fluids	18	(16)
Bhimanagouda S. Patil, Jun Yu, Deepak V. Dandekar, Romeo T. Toledo, Rakesh K. Singh, and Leonard M. Pike
3. Methods for the Separation of Limonoids from Citrus	34	(18)
Guddadarangavvanahally K. Jayaprakasha, Jennifer S. Brodbelt, Narayan G. Bhat, and Bhimanagouda S. Patil
4. Characterization of Flavonoids by Tandem Mass Spectrometry and Metal Complexation Strategies	52	(18)
Jennifer S. Brodbelt, Junmei Zhang, Michael Pikulski, Barry D. Davis, Basavaraj Girennavar, Guddadarangavvanahally K. Jayaprakasha, and Bhimanagouda S. Patil
5. Powerful Analytical Tools for Citrus Characterization: LC/MS and LC/NMR Characterization of Polymethoxylated Flavones	70	(12)
Claus O. Schmidt, Gerhard E. Krammer, Berthold Weber, Detlef Stöckigt, Stefan Brennecke, Günter Kindel, and Heinz-Jürgen Bertram
Bioavailability and Toxicity of Limonoids
6. Long-Term Screening Study on the Potential Toxicity of Limonoids	82	(13)
Edward G. Miller, Reed P. Gibbins, Samuel E. Taylor, Jame E. McIntosh, and Bhimanagouda S. Patil
7. Citrus Limonoid Bioavailability in Humans	95	(9)
Andrew P. Breksa III, Gary D. Manners, Robert A. Jacob, and Shin Hasegawa
Health Properties of Bioactive Compounds in Citrus
8. Citrus Flavonoid Nobiletin Suppresses Azoxymethane-Induced Rat Colon Tumorigenesis	104	(17)
Rikako Suzuki, Hiroyuki Kohno, Shigeyuki Sugie, Akira Murakami, Masamichi Yano, Hajime Ohigashi, and Takuji Tanaka
9. Comparison of the Chemoprotection Conferred by Grapefruit and Isolated Bioactive Compounds against Colon Cancer	121	(9)
Nancy D. Turner, Jairam Vanamala, Tety Leonardi, Bhimanagouda S. Patil, Mary E. Murphy, Yingxue C. Liu, Naisyin Wang, Leonard M. Pike, Robert S. Chapkin, and Joanne R. Lupton
10. Citrus Limonoids and Flavonoids: Enhancement of Phase II Detoxification Enzymes and Their Potential in Chemoprevention	130	(14)
Hassan Ahmad, Jiaxing Li, Maria Polson, Kimberly Mackie, Walter Quiroga, and Bhimanagouda S. Patil
11. Prevention of Drug-Induced Programmed and Unprogrammed Cell Death by Citrus Flavonoids	144	(17)
Sidhartha D. Ray, Daniel Zinkovsky, Ellida Bulku, and Bhimanagouda S. Patil
12. Antioxidant Effects of Citrus Flavonoid Consumption	161	(14)
John R. Burgess and Juan E. Andrade
13. Citrus sp.: A Source of Flavonoids of Pharmaceutical Interest	175	(11)
Ana Ortuño, Pedro Gómez, Ana Báidez, Victor Frias, and José A. Del Rio
14. Modulation of Cholesterol and Triacylglycerol Biosynthesis by Citrus Polymethoxylated Flavones: Cholesterol-Lowering Properties of Citrus Flavonoids	186	(13)
John A. Manthey and Elzbieta M. Kurowska
15. The Health Benefits of Modified Citrus Pectin	199	(12)
Isaac Eliaz, John Guardino, and Kerry Hughes
16. Obesity, Metabolic Syndrome, and the Benefits of Citrus	211	(8)
Ken Fujioka and Michael W. Lee
17. Whither Grapefruit and Drug Interaction?	219	(16)
Basavaraj Girennavar, Shibu M. Poulose, Jennifer S. Brodbelt, Guddadarangavvanahally K. Jayaprakasha, Narayan G. Bhat, and Bhimanagouda S. Patil
18. Grapefruit and Cancer: A Review	235	(19)
Kristine Cuthrell and Loic Le Marchand
Consumer Trends
19. Trends in Consumer Attitudes toward Food and Health: from Food Biotechnology to Personalized Nutrition	254	(9)
David B. Schmidt
Indexes
Author Index	263	(2)
Subject Index	265