The Power of Functional Resins in Organic Synthesis

by Albericio, Fernando; Tulla-Puche, Judit

• ISBN13: 9783527319367
• ISBN10: 3527319360
• Edition: 1st
• Format: Hardcover
• Copyright: 2008-11-17
• Publisher: Wiley-VCH

Summary

Complementary to the book cluster of combinatorial synthesis, this title provides unique information on the power of functional resins in organic synthesis. As such, it contains everything you need to know -- from supported reagents, to scavengers, resins, and the synthesis of biomolecules and natural products. With functional resins saving time and energy by simplifying work-up procedures thereby protecting natural resources and improving the synthesis, this text is an invaluable companion for all chemists and biochemists working in university research and industry.

Author Biography

Judit Tulla-Puche is a postdoctoral fellow in the group of Professor Fernando Albericio. She received her Ph.D. in chemistry at the University of Minnesota under the supervision of Professor George Barany, and then moved to the Barcelona Science Park. Her research efforts are directed at the synthesis of cyclic peptides and depsipeptides with anticancer activity, and the development of drug delivery methodologies.

Fernando Albericio is the Executive Director of the Barcelona Science Park and group leader at the Institute for Research in Biomedicals. His major research interests cover practically all aspects of peptide synthesis and combinatorial chemistry methodologies, as well as synthesis of peptides and small molecules with therapeutic activities. He has published over 400 papers and is currently editor of the International Journal of Peptide Research and Therapeutics.

Table of Contents

Introduction

The (Classic Concept of) Solid Support

Molecularly Imprinted Polymers

Nanoparticles Functionalized with Bioactive Molecules: Biomedical Applications

Solid-Supported Reagents And Scavengers

Oxidizing and Reducing Reagents

Base and Acid Reagents

Nucleophilic, Electrophilic, and Radical Reactions

Coupling and Introducing Building Block Reagents

Supported/Tagged Scavengers for Facilitating High-Throughput Chemistry

Metal Scavengers

Resin-Bound Catalysts

Polymer-Supported Organocatalysts

Transition Metal Catalysts

Chiral Auxiliaries on Solid Support

Immobilized Enyzmes in Organic Synthesis

Resins For Solid-Phase Synthesis

Acid-Labile Resins

Base/Nucleophile-Labile Resins

Safety-Catch and Traceless Linkers/Resins in SPOS

Photolabile and Miscellaneous Linkers/Resins

Solid-Phase Synthesis Of Biomolecules. The State Of The Art (From The Resin Point Of View)

Peptides

Oligonucleotides and their Derivatives

Oligosacharides

High Throughput Synthesis of Natural Products

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