Practical Organic Synthesis A Student's Guide

by Keese, Reinhart; Brä; ndle, Martin P.; Toube, Trevor P.

• ISBN13: 9780470029657
• ISBN10: 047002965X
• Edition: 1st
• Format: Hardcover
• Copyright: 2006-06-16
• Publisher: WILEY

Summary

Success in an experimental science such as chemistry depends on good laboratory practice, a knowledge of basic techniques, and the intelligent and careful handling of chemicals.Practical Organic Synthesis is a concise, useful guide to good laboratory practice in the organic chemistry lab with hints and tips on successful organic synthesis. Topics covered include: safety in the laboratory environmentally responsible handling of chemicals and solvents crystallisation distillation chromatographic methods extraction and work-up structure determination by spectroscopic methods searching the chemical literature laboratory notebooks writing a report hints on the synthesis of organic compounds disposal and destruction of dangerous materials drying and purifying solventsPractical Organic Synthesis is based on a successful course in basic organic chemistry laboratory practice which has run for several years at the ETH, Zurich and the University of Berne, and its course book Grundoperationen, now in its sixth edition.Condensing over 30 years of the authors' organic laboratory teaching experience into one easy-to-read volume, Practical Organic Synthesis is an essential guide for those new to the organic chemistry laboratory, and a handy benchtop guide for practising organic chemists.

Author Biography

Reinhart Keese is the author of Practical Organic Synthesis: A Student's Guide, published by Wiley.

Martin P. Brändle is the author of Practical Organic Synthesis: A Student's Guide, published by Wiley.

Trevor P. Toube is the author of Practical Organic Synthesis: A Student's Guide, published by Wiley.

Table of Contents

Preface	vii
CHAPTER 1 Accident Prevention and First Aid	1	(8)
1.1 Safety	1	(3)
1.2 Avoiding Accidents	4	(5)
CHAPTER 2 Environmentally Responsible Handling of Chemicals and Solvents	9	(10)
2.1 Dangerous Materials: Poisons, Laws, Regulations and Classes	10	(1)
2.2 EU Poison Regulations	10	(3)
2.3 Concentration Limits	13	(1)
2.4 Chemical Carcinogens	14	(5)
CHAPTER 3 Crystallisation	19	(8)
CHAPTER 4 Distillation	27	(10)
4.1 Some Theoretical Considerations	28	(2)
4.2 Distillation in Practice	30	(7)
CHAPTER 5 Chromatographic Methods	37	(18)
5.1 Basic Principles	37	(3)
5.2 Analytical and Preparative Thin—Layer Chromatography	40	(2)
5.3 Column Chromatography	42	(7)
5.4 Rapid Column Chromatography	49	(2)
5.5 HPLC	51	(4)
CHAPTER 6 Extraction and Isolation	55	(8)
6.1 Separation of Mixtures According to Acidity	56	(7)
CHAPTER 7 Structure Determination Using Spectroscopic Methods	63	(10)
7.1 Infrared Spectroscopy (IR)	63	(1)
7.2 Mass Spectrometry (MS)	64	(1)
7.3 Nuclear Magnetic Resonance Spectroscopy (NMR)	64	(1)
7.4 Ultraviolet and Visible Spectroscopy (UV/VIS)	64	(9)
CHAPTER 8 Searching the Chemical Literature	73	(38)
8.1 The Information Mountain	73	(1)
8.2 Strategy	74	(1)
8.3 Databases	74	(31)
8.4 Reviews	105	(2)
8.5 Monographs, Reference Works and Handbooks	107	(1)
8.6 Data Collections	108	(3)
CHAPTER 9 Laboratory Notebooks	111	(4)
CHAPTER 10 Writing a Report	115	(4)
CHAPTER 11 Example of a Laboratory Report	119	(4)
CHAPTER 12 Hints on the Synthesis of Organic Compounds	123	(24)
12.1 The Route to Success	123	(6)
12.2 Some Tips on Handling Water- and Air-Sensitive Substances	129	(7)
12.3 Hints on Working at Low Temperatures	136	(2)
12.4 Hints on the Synthesis and Analysis of Chiral Compounds	138	(2)
12.5 Hints on the Synthesis of Isotopically Labelled Compounds	140	(7)
CHAPTER 13 Disposal and Destruction of Dangerous Materials	147	(12)
13.1 Classification of Waste Material	148	(1)
13.2 Environmentally Acceptable Substances for Treating Dangerous Materials in the Laboratory	149	(1)
13.3 Special Instructions for the Destruction of the Main Classes of Dangerous Substances	149	(6)
13.4 Deactivation of Unknown Laboratory Chemicals	155	(1)
13.5 Waste Disposal	156	(3)
CHAPTER 14 Purification and Drying of Solvents	159	(26)
14.1 Some Drying Agents	160	(5)
14.2 Solvents	165	(20)
CHAPTER 15 EU R and S Phrases	185	(8)
15.1 R Phrases: Indication of Particular Risks	185	(2)
15.2 Combinations of R Numbers	187	(2)
15.3 S Phrases: Indication of Safety Precautions	189	(2)
15.4 Combinations of S Numbers	191	(2)
Index	193