Pre-eclampsia: Etiology and Clinical Practice

by Edited by Fiona Lyall , Michael Belfort

• ISBN13: 9780521169295
• ISBN10: 0521169291
• Edition: 1st
• Format: Paperback
• Copyright: 2010-12-16
• Publisher: Cambridge University Press

Summary

Pre-eclampsia is one of the leading causes of death and disability in mothers and babies. Over four million women worldwide will develop the disorder every year. This book, written by an international team of experts, focuses on both the scientific basis of pre-eclampsia and its management. The basic science section contains reviews of the most exciting research developments in pre-eclampsia. The clinical chapters provide a comprehensive review of the pertinent literature, highlighting data and ideas or developments in management. There is a section in each chapter (where relevant) that deals with practical management, giving clinicians a formulated treatment plan that they can implement directly. The book was originally published in 2007, and will have continuing relevance for all professionals interested in the reproductive sciences, and to obstetricians and physicians with an interest in pre-eclampsia.

Table of Contents

List of contributors

Preface

Basic Science

Trophoblast invasion in pre-eclampsia and other pregnancy disorders

Development of the utero-placental circulation: purported mechanisms for cytotrophoblast invasion in normal pregnancy and pre-eclampsia

In Vitro models for studying pre-eclampsia

Endothelial factors

The renin-angiotensin system in pre-eclampsia Fiona

Immunological factors and placentation: implications for pre-eclampsia

Immunological factors and placentation: implications for pre-eclampsia

The role of oxidative stress in pre-eclampsia

Placental hypoxia, hyperoxia and ischaemia-reperfusion injury in pre-eclampsia

Tenney-Parker changes and apoptotic versus necrotic shedding of trophoblast in normal pregnancy and pre-eclampsia

Dyslipidemia and pre-eclampsia

Pre-eclampsia a two-stage disorder: what is the linkage? Are there directed fetal/placental signals? Jim Roberts 13. High altitude and pre-eclampsia

The use of mouse models to explore fetal-maternal interactions underlying pre-eclampsia

Prediction of pre-eclampsia

Long-term implications of pre-eclampsia for maternal health

Clinical Practice

Classification and diagnosis of pre-eclampsia

Measuring blood pressure in pregnancy and pre-eclampsia

Immune maladaptation in the etiology of pre-eclampsia: an updated epidemiological perspective

Genetics of pre-eclampsia and counselling the patient who has developed pre-eclampsia

Thrombophilias and pre-eclampsia

Medical illness and the risk of pre-eclampsia

The kidney and pre-eclampsia

Management of mild pre-eclampsia

Management of severe pre-eclampsia

The differential diagnosis of pre-eclampsia and eclampsia

Complications of pre-eclampsia

Central nervous system findings in pre-eclampsia and eclampsia

Pathogenesis and treatment of eclampsia

Anaesthesia for the pre-eclamptic patient

Critical care management of severe pre-eclampsia

The role of maternal and fetal Doppler in pre-eclampsia

Pregnancy-induced hypertension - the effects on the newborn

Medico-legal implications of the diagnosis of pre-eclampsia

Subject Index

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