Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

by Favus, Murray J.; Christakos, Sylvia; Goldring, Steven R.; Hendy, Geoffrey N.; Holick, Michael F.

• ISBN13: 9780397517633
• ISBN10: 0397517637
• Format: Paperback
• Copyright: 1996-06-01
• Publisher: Lippincott Williams & Wilkins

Table of Contents

Contributing Authors	xi	(6)
The American Society for Bone and Mineral Research	xvii	(2)
John G. Haddad, Jr.
Gideon A. Rodan
Preface to the First Edition	xix	(2)
Murray J. Favus
Preface to the Third Edition	xxi	(2)
Murray J. Favus
Acknowledgments	xxiii
Section I. Anatomy and Biology of Bone Matrix and Cellular Elements	3	(38)
1. Anatomy and Ultrastructure of Bone	3	(8)
Roland E. Baron
2. Osteoblast Cell Biology -- Lineage and Functions	11	(5)
J. Edward Puzas
3. Bone-Resorbing Cells	16	(8)
Gregory R. Mundy
4. Bone Matrix Proteins and the Mineralization Process	24	(5)
John D. Termine
Pamela Gehron Robey
5. Regulation of Bone Remodeling	29	(6)
Ernesto Canalis
6. The Osteoblast Lineage--Embryologic Origins and the Differentiation Sequence	35	(6)
Jane E. Aubin
Arnold Kahn
Section II. Calcium, Magnesium, Phosphorus Homeostasis and Physiology, and Biochemistry of Calcium Regulating Hormones	41	(50)
7. Calcium, Magnesium and Phosphorus: Intestinal Absorption	41	(8)
Neil A. Breslau
8. Calcium, Magnesium and Phosphorus: Renal Handling and Urinary Excretion	49	(8)
Neil A. Breslau
9. Mineral Balance and Homeostasis	57	(6)
Arthur E. Broadus
10. Synthesis, Circulating Heterogeneity, and Metabolism of Parathyroid Hormone	63	(5)
Gino V. Segre
Edward M. Brown
11. Parathyroid Hormone: Mechanism of Action	68	(3)
Henry M. Kronenberg
12. Parathyroid-Hormone-Related Protein	71	(3)
Gordon J. Strewler
Robert A. Nissenson
13. Vitamin D: Photobiology, Metabolism, Mechanism of Action and Clinical Applications	74	(8)
Michael F. Holick
14. Calcitonin	82	(9)
Leonard J. Deftos
Section III. Clinical Evaluation of Bone and Mineral Disorders	91	(86)
15. History and Physical Examination	91	(2)
Peter M. Sklarin
Dolores M. Shoback
16. Blood, Calcium, Phosphorus, and Magnesium	93	(3)
Anthony A. Portale
17. Parathyroid Hormone and Calcitonin	96	(9)
Lawrence E. Mallette
Robert F. Gagel
18. Parathyroid-Hormone-Related Protein Assays	105	(4)
William J. Burtis
19. Vitamin D Metabolites	109	(5)
Thomas L. Clemens
John S. Adams
20. Biochemical Markers of Bone Turnover	114	(5)
David R. Eyre
21. Radiologic Evaluation of Bone Mineral in Children	119	(15)
Richard M. Shore
Andrew K. Poznanski
22. Scintigraphy in Metabolic Bone Disease	134	(8)
David C. Wang
Sambasiva R. Kottamasu
Kastytis C. Karvelis
23. Bone Density Measurement and the Management of Osteoporosis	142	(10)
C. Conrad Johnston, Jr.
Charles W. Slemenda
L. Joseph Melton III
24. Radiology of Osteoporosis and Other Metabolic Bone Diseases	152	(13)
Harry K. Genant
25. Bone Biopsy and Histomorphometry in Clinical Practice	165	(3)
Robert R. Recker
26. Molecular Diagnosis of Bone and Mineral Disorders	168	(9)
Robert F. Gagel
Gilbert J. Cote
Section IV. Disorders of Serum Minerals	177	(71)
27. Hypercalcemia: Pathogenesis, Clinical Manifestations, Differential Diagnosis, and Management	177	(4)
Elizabeth Shane
28. Primary Hyperparathyroidism	181	(6)
John P. Bilezikian
29. Familial Hyperparathyroid Syndromes	187	(3)
Hunter Heath III
Maurine R. Hobbs
30. Familial Hypocalciuric Hypercalcemia	190	(2)
Stephen J. Marx
31. Tertiary Hyperparathyroidism and Refractory Secondary Hyperparathyroidism	192	(6)
Susan C. Galbraith
L. Darryl Quarles
32. Humoral Hypercalcemia of Malignancy	198	(5)
Andrew F. Stewart
33. Hypercalcemia in Hematologic Malignancies and in Solid Tumors Associated with Extensive Localized Bone Destruction	203	(3)
Gregory R. Mundy
34. Hypercalcemia Due to Granuloma-Forming Disorders	206	(3)
John S. Adams
35. Hypercalcemic Syndromes in Infants and Children	209	(4)
Craig B. Langman
36. Miscellaneous Causes of Hypercalcemia	213	(4)
Kai H. Yang
Andrew F. Stewart
37. Hypocalcemia: Pathogenesis, Differential Diagnosis, and Management	217	(3)
Elizabeth Shane
38. Hypoparathyroidism	220	(3)
David Goltzman
David E. C. Cole
39. Parathyroid Hormone Resistance Syndromes	223	(5)
Michael A. Levine
40. Neonatal Hypocalcemia	228	(2)
Thomas O. Carpenter
41. Miscellaneous Causes of Hypocalcemia	230	(4)
Karl L. Insogna
Andrew F. Stewart
42. Magnesium Depletion and Hypermagnesemia	234	(4)
Robert K. Rude
43. Hyperphosphatemia and Hypophosphatemia	238	(10)
Keith A. Hruska
John Connolly
Section V. Metabolic Bone Diseases	248	(114)
Section V. Introduction	248	(1)
Sundeep Khosla
Michael Kleerekoper
44. Epidemiology of Osteoporosis	249	(4)
Richard D. Wasnich
45. Pathogenesis of Postmenopausal Osteoporosis	253	(1)
Robert P. Heaney
46. Physical Activity and Regulation of Bone Mass	254	(2)
Robert Marcus
47. Prevention of Osteoporosis	256	(6)
Robert Lindsay
48. Nutrition and Osteoporosis	262	(2)
Robert P. Heaney
49. Evaluation and Treatment of Postmenopausal Osteoporosis	264	(8)
Michael Kleerekoper
Louis V. Avioli
50. The Special Problem of Hip Fracture	272	(3)
Eric S. Orwoll
51. Juvenile Osteoporosis	275	(3)
Michael E. Norman
52. Glucocorticoid and Drug-Induced Osteoporosis	278	(5)
Barbara P. Lukert
53. Osteoporosis in Men	283	(3)
Jeffrey A. Jackson
54. Hyperthryoidism, Thyroid Hormone Replacement, and Osteoporosis	286	(3)
Daniel T. Baran
55. Miscellaneous Causes of Osteoporosis	289	(4)
Socrates E. Papapoulos
56. Orthopeidc Complications of Osteoporosis	293	(6)
Thomas A. Einhorn
57. Osteoporosis and Rheumatic Diseases	299	(2)
Steven R. Goldring
58. Nutritional Rickets and Osteomalacia	301	(5)
Gordon L. Klein
59. Metabolic Bone Disease in Gastrointestinal, Hepatobiliary, and Pancreatic Disorders	306	(5)
D. Sudhaker Rao
Mahalakshmi Honasoge
60. Vitamin D-Dependent Rickets	311	(5)
Uri A. Liberman
Stephen J. Marx
61. Hypophosphatemic Vitamin D-Resistant Rickets	316	(3)
Francis H. Glorieux
62. Tumor-Induced Rickets and Osteomalacia	319	(7)
Marc K. Drezner
63. Hypophosphatasia	326	(2)
Michael P. Whyte
64. Fanconi Syndrome and Renal Tubular Acidosis	328	(5)
Russell W. Chesney
65. Drug-Induced Osteomalacia	333	(4)
Daniel D. Bikle
66. Metabolic Bone Disease of Total Parenteral Nutrition	337	(4)
Gordon L. Klein
67. Renal Osteodystrophy in Adults and Children	341	(21)
William G. Goodman
Jack W. Coburn
Eduardo Slatopolsky
Isidro B. Salusky
Section VI. Genetic, Developmental, and Dysplastic Skeletal Disorders	362	(28)
Section VI. Introduction	362	(1)
Michael P. Whyte
68. Sclerosing Bone Dysplasias	363	(17)
Michael P. Whyte
69. Fibrous Dysplasia	380	(2)
Michael P. Whyte
70. Osteogenesis Imperfecta	382	(3)
Michael P. Whyte
71. Chondrodystrophies and Mucopolysaccharidoses	385	(5)
Michael P. Whyte
Section VII. Acquired Disorders of Cartilage and Bone	390	(19)
Section VII. Introduction	390	(1)
Michael P. Whyte
72. Skeletal Neoplasms	391	(8)
Michael P. Whyte
73. Ischemic Bone Disease	399	(4)
Michael P. Whyte
74. Infiltrative Disorders of Bone	403	(6)
Michael P. Whyte
Section VIII. Paget's Disease	409	(13)
75. Paget's Disease of Bone	409	(13)
Ethel S. Siris
Section IX. Extraskeletal (Ectopic) Calcification and Ossification	422	(10)
Section IX. Introduction	422	(2)
Michael P. Whyte
76. Tumoral Calcinosis	424	(2)
Michael P. Whyte
77. Dermatomyositis	426	(2)
Michael P. Whyte
78. Fibrodysplasia (Myositis) Ossificans Progressive	428	(4)
Michael P. Whyte
Frederick S. Kaplan
Eileen Shore
Section X. Nephrolithiasis	432	(15)
Section X. Introduction	432	(1)
Murray J. Favus
79. Nephrolithiasis	433	(5)
Fredric L. Coe
Joan H. Parks
80. Urologic Aspects of Nephrolithiasis Management	438	(9)
James E. Lingeman
Section XI. Appendix	447	(20)
i. Growth Charts for Males and Females	447	(2)
ii. Ossification Centers	449	(2)
iii. Laboratory Values of Importance for Calcium Metabolism and Metabolic Bone Disease	451	(2)
iv. Mineral and Vitamin D RDAs for Infants, Children, and Adults	453	(1)
v. Formulary of Drugs Commonly Used in Treatment of Mineral Disorders	454	(4)
vi. Structure of Naturally Occurring Vitamin D and Synthetic Analogs	458	(1)
vii. Dynamic Tests	459	(4)
viii. Bone Density Reference Data	463	(4)
Subject Index	467