Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

by Favus, Murray J.; Christakos, Sylvia; Kleerekoper, Michael (CON)

• ISBN13: 9780781700832
• ISBN10: 0781700833
• Edition: 2nd
• Format: Paperback
• Copyright: 1993-08-01
• Publisher: Raven Pr

Table of Contents

Contributors
The American Society for Bone and Mineral Research
Introduction from the First Edition
Preface to the Second Edition
Acknowledgments
Anatomy and Ultrastructure of Bone	p. 3
Molecular Defects of Bone Development	p. 10
The Osteoblast	p. 15
Bone Matrix Proteins and the Mineralization Process	p. 21
Bone Resorbing Cells	p. 25
Regulation of Bone Remodeling	p. 33
Physiological Functions of Calcium, Magnesium, and Phosphorus and Mineral Ion Balance	p. 41
Intestinal Absorption of Calcium, Magnesium, and Phosphorus	p. 46
Urinary Excretion of Calcium, Magnesium, and Phosphorus	p. 50
Secretion, Metabolism, and Circulating Heterogeneity of Parathyroid Hormone	p. 55
Parathyroid Hormone: Mechanism of Action	p. 58
Parathyroid Hormone-Related Protein	p. 61
Vitamin D: Metabolism and Mechanism of Action	p. 63
Calcitonin	p. 70
Regulation of Bone Mineral Homeostasis: An Integrated View	p. 76
History and Physical Examination	p. 83
Collection, Preservation, and Analysis of Urine in the Evaluation of Mineral Metabolism, Bone Disease, and Nephrolithiasis	p. 84
Blood Calcium, Phosphorus, and Magnesium	p. 87
Parathyroid Hormone and Calcitonin	p. 90
Parathyroid Hormone-Related Protein Assays	p. 99
Vitamin D and Metabolites	p. 103
Markers of Bone Formation and Resorption	p. 108
Blood Aluminum in Renal Osteodystrophy	p. 112
Radiologic Evaluation of Bone Mineral in Children	p. 115
Scintigraphy in Metabolic Bone Disease	p. 129
Bone Density Measurement and the Management of Osteoporosis	p. 137
Bone Biopsy and Histomorphometry in Clinical Practice	p. 146
Hypercalcemia: Pathogenesis, Clinical Manifestations, and Differential Diagnosis	p. 153
Primary Hyperparathyroidism	p. 155
Tertiary Hyperparathyroidism and Refractory Secondary Hyperparathyroidism	p. 159
Familial Hyperparathyroid Syndromes	p. 164
Familial Hypocalciuric Hypercalcemia	p. 166
Humoral Hypercalcemia of Malignancy	p. 169
Hypercalcemia in Hematologic Malignancies and in Solid Tumors Associated with Extensive Localized Bone Destruction	p. 173
Unusual Causes of Malignancy-Associated Hypercalcemia	p. 176
Hypercalcemia Resulting from Medications	p. 177
Hypercalcemia Due to Granuloma-Forming Disorders	p. 178
The Milk-Alkali Syndrome	p. 181
Immobilization	p. 181
Hypercalcemic Syndromes in Infants and Children	p. 182
Endocrine Causes of Hypercalcemia Other Than Primary Hyperparathyroidism	p. 184
Management of Hypercalcemia	p. 185
Hypocalcemia: Pathogenesis, Differential Diagnosis, and Management	p. 188
Protein Binding Abnormalities	p. 190
Hypoparathyroidism	p. 191
Parathyroid Hormone Resistance Syndromes	p. 194
Hypocalcemia Due to Magnesium Deficiency	p. 200
Hypocalcemia Due to Pancreatitis	p. 202
Hypocalcemia Due to Vitamin D Disorders	p. 203
Hypocalcemia Due to Hyperphosphatemia	p. 204
Medications That Cause Hypocalcemia	p. 205
Hypocalcemia in Acute Illness	p. 205
Neonatal Hypocalcemia	p. 207
Magnesium Deficiency and Hypermagnesemia	p. 210
Hyperphosphatemia and Hypophosphatemia	p. 213
Evaluation and Treatment of Postmenopausal Osteoporosis	p. 223
Radiology of Osteoporosis	p. 229
Prevention of Osteoporosis	p. 240
Juvenile Osteoporosis	p. 245
Regional Osteoporosis	p. 248
Steroid and Drug-Induced Osteopenia	p. 250
Osteoporosis in Men	p. 255
Miscellaneous Causes of Osteoporosis	p. 258
Serum Fluoride Levels	p. 262
Nutritional Rickets and Osteomalacia	p. 264
Metabolic Bone Disease in Gastrointestinal and Biliary Disorders	p. 268
Vitamin D Dependent Rickets	p. 274
Hypophosphatemic Vitamin D Resistant Rickets	p. 279
Tumor-Associated Rickets and Osteomalacia	p. 282
Hypophosphatasia	p. 288
Fanconi Syndrome and Renal Tubular Acidosis	p. 291
Drug-Induced Osteomalacia	p. 296
Metabolic Bone Disease of Total Parenteral Nutrition	p. 300
Renal Osteodystrophy in Adults and Children	p. 304
Sclerosing Bone Dysplasias	p. 327
Fibrous Dysplasia	p. 344
Osteogenesis Imperfecta	p. 346
Chondrodystrophies and Mucopolysaccharidoses	p. 350
Skeletal Neoplasms	p. 355
Ischemic Bone Disease	p. 363
Infiltrative Disorders of Bone	p. 367
Sarcoidosis	p. 371
Paget's Disease of Bone	p. 375
Tumoral Calcinosis	p. 389
Dermatomyositis	p. 391
Fibrodysplasia (Myositis) Ossificans Progressiva	p. 393
Nephrolithiasis	p. 399
App. i. Growth Charts for Males and Females	p. 407
App. ii. Ossification Centers	p. 409
App. iii. Laboratory Values of Importance for Calcium Metabolism and Metabolic Bone Disease	p. 411
App. iv. Mineral and Vitamin D RDA for Infants, Children, and Adults	p. 413
App. v. Formulary of Drugs Commonly Used in Treatment of Mineral Disorders	p. 414
App. vi. Structure of Naturally Occurring Vitamin D and Synthetic Analogs	p. 417
App. vii. Dynamic Tests	p. 418
App. viii. Molecular Defects and Models for Disorders of Bone and Mineral Metabolism	p. 423
App. ix. Bone Density Reference Data	p. 426
Subject Index	p. 431
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