Principles of Anticancer Drug Development

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  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2010-07-01
  • Publisher: Humana Pr Inc

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A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Table of Contents

Basic Biosatistics for the Clinical Trialistp. 3
Fundamental Concepts in Clinical Pharmacologyp. 37
Bioanalytical Methods in Clinical Drug Developmentp. 63
Preclinical Models for Anticancer Drug Developmentp. 89
Phase I Clinical Trials with Anticancer Agentsp. 117
Phase II Trials with Anticancer Agentsp. 141
Phase III Clinical Trials with Anticancer Agentsp. 163
Pharmacokinetic Studies in Early Anticancer Drug Developmentp. 189
Pharmacodynamic Studies in Early Phase Drug Developmentp. 215
Prediction of Antitumor Responsep. 257
Imaging Studies in Anticancer Drug Developmentp. 275
Role of the US Food and Drug Administration in Cancer Drug Developmentp. 305
Early Clinical Trials with Cytotoxic Agentsp. 335
Challenges and Saccesses in Developing Effective Anti-angiogenic Agentsp. 347
Targeted Therapeutics in Cancer Treatmentp. 403
Cancer Chemopreventionp. 463
Combined Modality Therapy in Cancer Managementp. 483
Cancer Vaccinesp. 519
Optimising the Development of Antibodies as Treatment for Cancerp. 535
Oligonucleotide Therapeuticsp. 569
Anticancer Drug Development in Pediatric Patientsp. 589
Clinical Trials in Special Populationsp. 603
NCI-Sponsored Clinical Trialsp. 631
Indexp. 659
Table of Contents provided by Ingram. All Rights Reserved.

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