Principles of Development

by Wolpert, Lewis; Beddington, Rosa; Jessell, Thomas; Lawrence, Peter; Meyerowitz, Elliot; Smith, Jim

• ISBN13: 9780199249398
• ISBN10: 0199249393
• Edition: 2nd
• Format: Hardcover
• Copyright: 2001-12-27
• Publisher: Oxford University Press

Summary

Led by Lewis Wolpert, an influential developmental biologist, this distinguished team of authors presents a new and revised edition of the best-selling and popular textbook Principles of Development . Central to their approach is an emphasis on principles and key concepts as well as the idea that understanding how genes control cell behavior is the key to comprehending development. The authors assume that students are familiar with the basics of cell biology and genetics but also provide thorough explanations of all key concepts in the text, such as the control of gene activity. The book focuses on those systems-such as vertebrates and Drosophila-that best illuminate the common principles of development, and also discusses other systems like the nematode and sea urchin. A unique feature of the book is its coverage of plant development, which is usually neglected in other textbooks but has significant relevance to the field of developmental biology. Full of spectacular illustrations and diagrams, Principles of Development, Second Edition , provides the excellent content and quality design of its predecessor, and also incorporates valuable new material.

Table of Contents

List of headings	xi
Text acknowledgements	xix
Figure acknowledgements	xxi
History and basic concepts	1	(26)
The origins of developmental biology	3	(6)
A conceptual tool kit	9	(18)
Model systems	27	(38)
Model organisms: vertebrates	29	(19)
Model organisms: invertebrates	48	(6)
Model systems: plants	54	(3)
Identifying developmental genes	57	(8)
Patterning the vertebrate body plan I: axes and germ layers	65	(44)
Setting up the body axes	67	(16)
The origin and specification of the germ layers	83	(26)
Patterning the vertebrate body plan II: the mesoderm and early nervous system	109	(34)
Somite formation and patterning	110	(15)
Neural induction and the role of the organizer	125	(18)
Development of the Drosophila body plan	143	(48)
Maternal genes set up the body axes	145	(9)
Polarization of the body axes during oogenesis	154	(3)
Zygotic genes pattern the early embryo	157	(9)
Segmentation: activation of the pair-rule genes	166	(4)
Segment polarity genes and compartments	170	(12)
Segmentation: selector and homeotic genes	182	(9)
Development of nematodes, sea urchins, ascidians, and slime molds	191	(30)
Nematodes	192	(9)
Echinoderms	201	(8)
Ascidians	209	(3)
Cellular slime molds	212	(9)
Plant development	221	(32)
Embryonic development	222	(10)
Meristems	232	(11)
Flower development	243	(10)
Morphogenesis: change in form in the early embryo	253	(40)
Cell adhesion	254	(4)
Cleavage and formation of the blastula	258	(7)
Gastrulation	265	(13)
Neural tube formation	278	(3)
Cell migration	281	(6)
Directed dilation	287	(6)
Cell differentiation	293	(38)
The control of gene expression	295	(9)
Models of cell differentiation	304	(19)
The reversibility of patterns of gene activity	323	(8)
Organogenesis	331	(44)
The chick limb	331	(19)
Insect wings and legs	350	(9)
The nematode vulva	359	(3)
Internal organs: heart, blood vessels, lungs, kidneys, and teeth	362	(13)
Development of the nervous system	375	(42)
Specification of cell identity in the nervous system	376	(14)
The insect compound eye	390	(4)
Axonal guidance	394	(10)
Neuronal survival, synapse formation and refinement	404	(13)
Germ cells and sex	417	(30)
Determination of the sexual phenotype	418	(11)
The development of germ cells	429	(9)
Fertilization	438	(9)
Regeneration	447	(20)
Limb regeneration	448	(10)
Regeneration in Hydra	458	(9)
Growth and post-embryonic development	467	(26)
Growth	467	(15)
Molting and metamorphosis	482	(5)
Aging and sensescence	487	(6)
Evolution and development	493	(28)
Modification of development in evolution	495	(16)
Changes in the timing of developmental processes during evolution	511	(5)
Evolution of development	516	(5)
Glossary	521	(10)
Index	531