Principles of Medical Pharmacology

by Kalant, Harold; Grant, Denis M., Ph.D.; Mitchell, Jane

• ISBN13: 9780779699452
• ISBN10: 0779699459
• Edition: 7th
• Format: Paperback
• Copyright: 2006-06-09
• Publisher: Saunders Canada

Summary

Principles of Medical Pharmacology covers all aspects of medical pharmacology, making it the ideal text for students in pharmacology courses in medicine, biological sciences, pharmacy, and dentistry. The book provides a solid foundation of the principles of pharmacology. Principles are explained through the use of practical examples and case studies. The text covers all aspects of medical pharmacology, including a comprehensive discussion of the clinically important features of pharmacokinetics. This new Seventh Edition has been completely revised and updated to reflect the latest research in the field. Most chapters have been extensively rewritten, with many new authors involved in the preparation of this edition. More chapters written by clinician-investigators, with increased clinical information on factors determining choice and use of drugs Thoroughly updated information throughout to reflect the latest published research in the field New chapters on drugs used in dermatology; herbal remedies and dietary supplements; and clinical pharmacological principles in the pharmacotherapy of hypertension Completely revised content dealing with pharmacogenetics and pharmacogenomics; cardiovascular system overview; digitalis glycosides and other positive inotropic agents; drugs and the respiratory system; diuretics; drugs affecting hemostasis; drugs affecting erythropoiesis; pharmacotherapy of acid-peptic disorders; drugs used in treatment of intestinal motility disorders; drugs, alcohol and the liver; antiseptics, and disinfectants and sterilization; and poisonings and antidotal therapy New content on drug transporters and their role in drug resistance; antispasticity drugs; new drugs for Parkinsons, and their adverse effects; COX-2 inhibitors; rennin inhibitors; antibiotic-resistant organisms; new antiviral drugs; infectious disease control in hospitals; and molecular biological targets for anticancer medications Comprehensive discussion of the clinically important features of pharmacokinetics Expanded use of case histories to demonstrate the clinical relevance of basic pharmacology Enlarged Suggested Readings lists at the end of each chapter, with the addition of important electronic reference resources and online databases With 61 contributors

Table of Contents

Preface	ix
Contributors	xiii
PART I General Principles of Pharmacology
Introduction to General Pharmacology	3	(8)
H Kalant
Drug Solubility, Absorption, and Movement across Body Membranes	11	(16)
H Kalant
C Woodland
P Seeman
Drug Distribution	27	(7)
L Endrenyi
Drug Biotransformation	34	(16)
DS Riddick
Pharmacokinetics: Principles and Clinical Applications	50	(12)
L Endrenyi
Drug Clearance by Specific Organs	62	(6)
L Endrenyi
Dose-Response Relationships	68	(7)
L Endrenyi
Drug Receptors	75	(9)
J Mitchell
Signal Transduction Systems	84	(7)
J Mitchell
Pharmacogenetics and Pharmacogenomics	91	(16)
DM Grant
W Kalow
PART II Autonomic Nervous System and Neuromuscular Junction
Functional and Neurochemical Organization of the Autonomic Nervous System	107	(14)
AJ Lanca
Cholinergic Agonists and Antagonists	121	(16)
M Hong
Adrenergic Receptor Agonists	137	(19)
AJ Lanca
Adrenergic Receptor Antagonists	156	(16)
AJ Lanca
Neuromuscular Transmission and Drugs (Muscle Relaxants)	172	(15)
M Hong
PART III Central Nervous System
Functional and Neurochemical Organization of the Central Nervous System	187	(24)
AJ Lanca
Drugs That Modify Movement Control	211	(12)
AJ Lanca
Anti-seizure Drugs	223	(13)
WM Burnham
Opioid Analgesics and Antagonists	236	(16)
H Kalant
General Anaesthetics	252	(14)
FJL Carmichael
DA Haas
VWS Chan
Local Anaesthetics	266	(9)
DA Haas
FJL Carmichael
The Alcohols	275	(14)
H Kalant
JM Khanna
Drugs Used for Anxiety, Stress Disorders, and Insomnia	289	(14)
MK Romach
KA Schoedel
EM Sellers
Antipsychotics	303	(13)
D Mamo
S Kapur
P Seeman
Antidepressant and Mood-Stabilizing Agents	316	(18)
JJ Warsh
PP LI
Hallucinogens and Psychotomimetics	334	(19)
H Kalant
PART IV Mediators and Modifiers of Tissue Responses
The Eicosanoids	353	(11)
CR Pace-Asciak
D Kadar
Anti-inflammatory Analgesics	364	(19)
D Kadar
Autacoids	383	(12)
D Kadar
Histamine and Antihistamines	395	(12)
D Kadar
PART V Cardiovascular System
Cardiovascular System Overview and Organization	407	(15)
U Ackermann
Digitalis Glycosides and Other Positive Inotropic Agents	422	(8)
G Moe
Anti-arrhythmic Drugs	430	(18)
A Sarkozy
P Dorian
Vasodilators and the Pharmacological Treatment of Hypertension	448	(18)
RI Ogilvie
Dyslipidemias and Antihyperlipidemic Drugs	466	(19)
AYY Cheng
LA Leiter
PART VI Respiratory, Renal, Blood, and Immune Systems
Drugs and the Respiratory System	485	(8)
KR Chapman
Diuretics	493	(13)
RMA Richardson
Drugs That Affect Hemostasis	506	(27)
EL Yeo
Drugs (Agents) That Affect Erythropoiesis	533	(12)
EL Yeo
Immune System Organization, Modulation, and Pharmacology	545	(12)
JW Semple
PART VII Gastrointestinal System
Pharmacotherapy of Acid-Peptic Disorders	557	(15)
Y Yuan
RH Hunt
Pharmacotherapy of Intestinal Motility Disorders and Inflammatory Bowel Disease	572	(12)
SC Ganguli
Drugs, Alcohol, and the Liver	584	(19)
H Kalant
EA Roberts
PART VIII Endocrine Systems
Vasopressin, Oxytocin, and Uterotonic Drugs	603	(10)
SR George
BP Schimmer
Thyroid Hormones and Antihyperthyroid Drugs	613	(7)
BP Schimmer
SR George
Gonadotropic and Gonadal Hormones	620	(15)
SR George
BP Schimmer
Insulin and Other Anti-diabetic Drugs	635	(12)
BP Schimmer
SR George
Adrenocortical Steroid Hormones	647	(14)
BP Schimmer
SR George
PART IX Anti-infective and Anti-neoplastic Chemotherapy
Principles of Antimicrobial Therapy	661	(9)
J Uetrecht
EJ Phillips
SL Walmsley
Antimicrobial Agents That Act on Microbial Cell Wall Formation	670	(19)
EJ Phillips
J Uetrecht
SL Walmsley
Antimicrobial and Antifungal Agents That Act on Cell Membranes	689	(8)
J Uetrecht
EJ Phillips
SL Walmsley
Antimicrobial Agents That Affect the Synthesis of Cellular Proteins	697	(15)
J Uetrecht
EJ Phillips
SL Walmsley
Drugs That Affect Cellular Nucleic Acid Synthesis	712	(12)
EJ Phillips
J Uetrecht
SL Walmsley
Chemotherapy of Common Parasitic Infections	724	(15)
JS Keystone
Antiviral Agents	739	(23)
SL Walmsley
Antiseptics, Disinfectants, and Sterilization	762	(14)
S Lim
K Iverson
MA Gardam
Anti-neoplastic Drugs	776	(21)
EX Chen
MJ Moore
PART X Special Topics of Pharmacology
Sources of Individual Variation in Drug Response	797	(6)
H Kalant
Adverse Drug Reactions	803	(9)
NH Shear
Drug Interactions	812	(11)
EM Sellers
K Schoedel
MK Romach
Perinatal Pharmacology	823	(9)
LA Magee
G Koren
Geriatric Clinical Pharmacology	832	(9)
DS Sitar
Vitamins and Other Micronutrients	841	(27)
WE Ward
Herbal Preparations and Nutritional Supplements	868	(10)
WE Ward
Drugs That Alter Bone Metabolism for the Treatment of Osteoporosis	878	(12)
JD Adachi
A Papaioannou
Drugs Used in Dermatology	890	(10)
Gae Wong
NH Shear
Chemical Carcinogenesis	900	(12)
AB Okey
PA Harper
Chemical Teratogenesis	912	(19)
PG Wells
Behavioural Pharmacology	931	(14)
LA Grupp
H Kalant
Drug Abuse and Drug Dependence	945	(14)
H Kalant
LA Grupp
Principles of Toxicology	959	(10)
C Woodland
PG Wells
Poisonings and Antidotal Therapy	969	(10)
C Woodland
Index	979