Principles in Microbiome Engineering

by Chang , Matthew W.; Lee, Sang Yup; Nielsen, Jens; Stephanopoulos, Gregory

• ISBN13: 9783527347254
• ISBN10: 3527347259
• Edition: 1st
• Format: Hardcover
• Copyright: 2022-05-09
• Publisher: Wiley-VCH

Summary

Principles in Microbiome Engineering

Provides an overview of the techniques and applications insight into the complex composition and interactions of microbiomes

Microbiomes, the communities of microorganisms that inhabit specific ecosystems or organisms, can be engineered to modify the structure of microbiota and reestablish ecological balance. In recent years, a better understanding of microbial composition and host-microbe interactions has led to the development of new applications for improving human health and increasing agricultural productivity and quality.

Principles in Microbiome Engineering introduces readers to the tools and applications involved in manipulating the composition of a microbial community to improve the function of an eco-system. Covering a range of key topics, this up-to-date volume discusses current research in areas such as microbiome-based therapeutics for human diseases, crop plant breeding, animal husbandry, soil engineering, food and beverage applications, and more. Divided into three sections, the text first describes the critical roles of systems biology, synthetic biology, computer modelling, and machine learning in microbiome engineering. Next, the volume explores various state-of-the-art applications, including cancer immunotherapy and prevention of diseases associated with the human microbiome, followed by a concluding section offering perspectives on the future of microbiome engineering and potential applications.

• Introduces a variety of applications of microbiome engineering in the fields of medicine, agriculture, and food and beverage products
• Presents current research into the complex interactions and relationships between microbiomes and biotic and abiotic elements of their environments
• Examines the use of technologies such as Artificial Intelligence (AI), Machine Learning (ML), and Big Data analytics to advance understanding of microbiomes
• Discusses the engineering of microbiomes to address human health conditions such as neuro psychiatric disorders and autoimmune and inflammatory diseases

Edited and authored by leading researchers in the rapidly evolving field, Principles in Microbiome Engineering is an essential resource for biotechnologists, biochemists, microbiologists, pharmacologists, and practitioners working in the biotechnology and pharmaceutical industries.

Author Biography

Matthew Chang, Associate Professor of Biochemistry, National University of Singapore (NUS); Director, Singapore Consortium for Synthetic Biology (SINERGY).

Sang Y. Lee, Distinguished Professor of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST).

Jens Nielsen, Chief Executive Officer, BioInnovation Institute, Denmark; Professor of Systems Biology, Chalmers University of Technology, Sweden.

Gregory Stephanopoulos, W.H. Dow Professor in Chemical Engineering and Biotechnology, Massachusetts Institute of Technology (MIT), USA.

Table of Contents

Section I: Advancing understanding of microbiome

Chapter 1: Systems biology and microbiome
Chapter 2: Synthetic biology and microbiome
Chapter 3: Computational modelling of microbiome and host-microbiome interactions
Chapter 4: Machine learning of the microbiome big data

Section II: Microbiome engineering

Chapter 5: Human microbiome engineering against pathogen infections
Chapter 6: Human microbiome engineering against cancer
Chapter 7: Human microbiome engineering against diabetes
Chapter 8: Human microbiome engineering against obesity
Chapter 9: Human microbiome engineering against mental disorders
Chapter 10: Human microbiome engineering against autoimmune and inflammatory disorders
Chapter 11: Husbandry microbiome engineering
Chapter 12: Plant-soil microbiome engineering
Chapter 13: Food microbiome engineering
Chapter 14: Beverage microbiome engineering

Section III: Perspectives on microbiome engineering

Chapter 15: Future perspectives on Microbiome and its applications