Principles of Molecular Cardiology

by Runge, Marschall S.; Patterson, Winston C.; Patterson, Cam

• ISBN13: 9781588292018
• ISBN10: 1588292010
• Edition: Illus.
• Format: Hardcover
• Copyright: 2005-04-08
• Publisher: Humana Pr Inc

Summary

An easy-to-read survey of all the latest developments in molecular cardiologic research and therapy. The authors explain in a readable style the complex process of the heart's development, the molecular basis of cardiovascular diseases, and the translation of these research advances to actual clinical treatments. The expert information provided here serves as an invaluable building block for novel treatments of cardiovascular diseases and includes a comprehensive discussion of cardiac function and dysfunction, coronary artery disease, cardiac arrhythmias, vascular diseases, and risk factors for cardiovascular disease. These state-of-the-art approaches to molecular cardiologic research include critical discussion of such topics as the molecular events that regulate angiogenesis and the potential for angiogenic therapy, emerging therapies for arrhythmias, and a description of the molecular biology of aging and its impact on the cardiovascular system.

Table of Contents

Foreword	p. v
Preface	p. vii
Contributors	p. xii
Overview
Cardiovascular Genetics	p. 3
Molecular Biology Applications in Cardiovascular Medicine	p. 11
Genomics and Its Application to Cardiovascular Disease	p. 45
Gene Therapy and Cardiovascular Diseases	p. 57
Stem Cells and Progenitor Cells in Cardiovascular Disease	p. 71
Myocardial Disease
Development of the Vertebrate Heart	p. 83
Inherited Myocardial Diseases	p. 105
Receptor-Signaling Pathways in Heart Failure	p. 123
Recent Insights into the Molecular Pathophysiology of Viral Myocarditis	p. 145
Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease	p. 155
Coronary Artery Disease
Coronary Artery Development	p. 167
Atherosclerosis	p. 185
Antiplatelet Drugs	p. 203
Myocardial Infarction	p. 219
Transplant Arteriopathy: Pathology, Pathogenesis, and Prospects for Treatment	p. 243
Thrombolysis: Scientific Basis for Current Therapy	p. 271
Coronary Restenosis	p. 291
Arrhythmias
Induction and Patterning of Purkinje Fiber Ne2rk	p. 311
Mechanisms of Sudden Cardiac Death	p. 323
Gene Therapy for Cardiac Arrhythmias	p. 353
Genetics and Arrhythmias	p. 359
Vascular Diseases
Therapeutic Angiogenesis for Ischemic Vascular Disease	p. 369
Nitric Oxide in Cardiovascular Biology and Pathophysiology	p. 387
Vasculitis	p. 399
Primary Pulmonary Hypertension	p. 413
The Molecular Basis of Cerebrovascular Malformations	p. 437
Thrombotic Vascular Disease	p. 451
Risk Factors
Risk Factors	p. 475
Vascular Aging: From Molecular to Clinical Cardiology	p. 517
Oxidative Stress	p. 549
Diabetes Mellitus: An Important Cardiovascular Risk Factor	p. 563
Vascular Inflammation as a Cardiovascular Risk Factor	p. 577
Index	p. 605
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