Principles of Molecular Regulation

by Conn, P. Michael; Means, Anthony R.; O'Malley, Bert W.

• ISBN13: 9780896036307
• ISBN10: 0896036308
• Edition: 1st
• Format: Hardcover
• Copyright: 2000-08-01
• Publisher: Springer Verlag

Summary

P. Michael Conn and Anthony Means have successfully assembled a panel of leading investigators to provide an integrated review of the key areas-membrane receptor-initiated cell signaling and nuclear-receptor initiated gene regulation. Chosen for the excellence of their research, these distinguished authors illuminate the molecular machinery underlying the regulatory processes of cells. In addition to their comprehensive review of the signaling mechanisms involving cell surface receptors, nuclear receptors, and ion channels, they detail the roles of calcium, lipids, cyclic AMP, protein kinases, and protein phosphatases. Capturing the excitement now present at this vibrant union of molecular biology, cell biology, and endocrinology, Principles of Molecular Regulation constitutes a major new resource for understanding the many and complex elements of biological regulation. Its up-to-date critical synthesis is certain to prove of high value to all basic and clinical investigators working with these processes today.

Table of Contents

Foreword	v
Preface	ix
Contributors	xiii
Part I. Signaling Mechanisms Initiated by Cell Surface Receptors
G Protein-Coupled Receptors and G Proteins	3	(24)
Alfredo Ulloa-Aguirre
P. Michael Conn
G Proteins Large and Small Guanine Nucleotide Binding Proteins: Cellular Comunication Networks	27	(14)
Thomas M. Wilkie
Michael A. White
The Insulin Receptor Kinase: Regulation and Therapeutic Significance	41	(14)
Barry I. Posner
Growth Hormone Action: Signaling via a JAK/STAT-Coupled Receptor	55	(30)
David J. Waxman
Stuart J. Frank
Regulation of Drosophila Visual Transduction Through a Supramolecular Signaling Complex	85	(14)
Craig Montell
Dictyostelium: A Model Experimental System for Elucidating the Pathways and Mechanisms Controlling Chemotaxis	99	(16)
Chang Y. Chung
Richard A. Firtel
gp 130-Related Cytokines	115	(20)
Christoph J. Auernhammer
Shalomo Melmed
Part II. Signaling Mechanisms Mediated by Ion Channels, Calcium, and Lipids
Ion Channels	135	(14)
Deborah J. Nelson
Harry A. Fozzard
Calcium Ions as Intracellular Messengers: Pathways and Actions	149	(38)
Stanko S. Stojilkovic
Melanija Tomic
Taka-aki Koshimizu
Fredrick Van Goor
Calcium and Calmodulin-Mediated Regulatory Mechanisms	187	(18)
Anthony R. Means
Protein Kinase C	205	(14)
Alexandra C. Newton
Nitric Oxide	219	(10)
Randy Krainock
Sean Murphy
Phospholipases	229	(20)
J. H. Exton
Part III. Cyclin AMP, Protein Kinases and Protein Phosphatases
Adenylyl Cyclases	249	(12)
Lutz Birnbaumer
Cyclic Nucleotide Phosphodiesterases	261	(16)
Marco Conti
Cyclic Nucleotide-Dependent Protein Kinases	277	(20)
Sharron H. Francis
Jackie D. Corbin
Protein Serine/Threonine Kinases	297	(14)
Jorg Heierhorst
Richard Pearson
James Horne
Steven Bozinovski
Bostjan Kobe
Bruce E. Kemp
Protein Serine/Threonine Phosphatases	311	(12)
Shirish Shenolikar
Protein Tyrosine Phosphatases	323	(28)
Cynthia V. Stauffacher
Harry Charbonneau
Part IV. Signaling Mechanisms Initiated by Nuclear Receptors
The Mechanism of Action of Steroid Hormone Receptors	351	(12)
Donald P. McDonnell
Orphan Nuclear Receptors	363	(22)
Deepak S. Lala
Richard A. Heyman
Coactivators and Corepressors	385	(10)
Neil J. McKenna
Zafar Nawaz
Sophia Y. Tsai
Ming-Jer Tsai
CREB Binding Protein--Coactivator Complexes	395	(12)
Riki Kurokawa
Christopher K. Glass
Part V. Molecular Regulation of Cell Proliferation and Death
Cell Cycle Checkpoints	407	(8)
Sally Kornbluth
Molecular Regulation of Apoptosis	415	(14)
Rosemary B. Evans-Stroms
John A. Cidlowski
T Cells and Immunosuppression	429	(10)
Andrew W. Taylor
Part VI. Rational Drug Discovery
Rational Drug Discovery and the Impact of New, Advanced Technologies	439	(22)
Jonathan Greer
Index	461