Principles of Molecular Rheumatology

by Tsokos, George C.

• ISBN13: 9780896037731
• ISBN10: 0896037738
• Format: Hardcover
• Copyright: 2000-08-01
• Publisher: Humana Pr Inc

Summary

George Tsokos and a panel of authoritative clinicians and researchers synthesize the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

Table of Contents

Preface	v
Contributors	xi
Part I. Molecular Mechanisms in Rheumatic Diseases
Genetics	3	(12)
Peter K. Gregersen
Viruses	15	(20)
Andras Perl
Apoptosis	35	(24)
John D. Mountz
Hui-Chen Hsu
Huang-Ge Zhang
Tong Zhou
Humoral Response	59	(16)
Gary S. Gilkeson
T-Cell Signaling	75	(12)
Gary A. Koretzky
Erik J. Peterson
Adhesion and Costimulatory Molecules	87	(22)
Vassiliki A. Boussiotis
Gordon J. Freeman
Lee M. Nadler
Transcription Factors	109	(18)
Henry K. Wong
Immune Complexes	127	(18)
Mark H. Wener
Complement	145	(16)
V. Michael Holers
Eicosanoids and Other Bioactive Lipids	161	(14)
Leslie J. Crofford
Collagens	175	(24)
Sergio A. Jimenez
Part II. Cellular Mechanisms in Rheumatic Diseases
T-Lymphocytes	199	(14)
Nilamadhab Mishra
Gary M. Kammer
B-Lymphocytes	213	(12)
Robert F. Ashman
Monocytes and Macrophages	225	(18)
James M. K. Chan
Sharon M. Wahl
Polymorphonuclear Cells	243	(16)
Michael H. Pillinger
Pamela B. Rosenthal
Bruce N. Cronstein
Synoviocytes	259	(8)
David E. Yocum
Chondrocytes	267	(12)
Tariq M. Haqqi
Donald D. Anthony
Charles J. Malemud
Osteoblasts and Osteoclasts	279	(14)
Stavros C. Manolagas
Animal Models	293	(18)
Thomas J. Lang
Charles S. Via
Part III. Pathogenesis of Rheumatic Diseases
Systemic Lupus Erythematosus	311	(14)
Stamatis-Nick C. Liossis
George C. Tsokos
Rheumatoid Arthritis	325	(38)
Richard M. Pope
Harris Perlman
Inflammatory Myopathies	363	(12)
Norbert Goebels
Reinhard Hohlfeld
Systemic Sclerosis	375	(10)
Timothy M. Wright
Vasculitis	385	(16)
Jorg J. Goronzy
Cornelia M. Weyand
Osteoarthritis	401	(12)
A. Robin Poole
Ginette Webb
Osteoporosis	413	(10)
Stavros C. Manolagas
Heritable Disorders of Connective Tissue	423	(16)
Petros Tsipouras
Part IV. Molecular Aspects of Treatment of Rheumatic Diseases
Corticosteroids	439	(12)
Henry K. Wong
George C. Tsokos
Cytotoxic Drugs	451	(14)
David A. Fox
W. Joseph McCune
Complement Inhibitors	465	(12)
Savvas C. Makrides
Cytokine Response Modifiers	477	(10)
Richard E. Jones
Larry W. Moreland
Restoration of Immune Tolerance	487	(12)
Woodruff Emlen
Metalloproteases and Their Modulation as Treatment in Osteoarthritis	499	(16)
Johanne Martel-Pelletier
Ginette Tardif
Julio Fernandes
Jean-Pierre Pelletier
Gene Therapy	515	(10)
Robert P. Kimberly
Index	525