This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system. Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development. The fully searchable online text and an image bank are available on thePoint.

Fundamental principles of pharmacology	p. 1
Drug-receptor interactions	p. 3
Pharmacodynamics	p. 19
Pharmacokinetics	p. 31
Drag metabolism	p. 49
Drug toxicity	p. 63
Principles of neuropharmacology	p. 75
Fundamental principles of neuropharmacology	p. 77
Principles of cellular excitability and electrochemical transmission	p. 79
Principles of nervous system physiology and pharmacology	p. 91
Principles of autonomic and peripheral nervous system pharmacology	p. 107
Cholinergic pharmacology	p. 109
Adrenergic pharmacology	p. 129
Local anesthetic pharmacology	p. 145
Principles of central nervous system pharmacology	p. 161
Pharmacology of GABAergic and glutamatergic neurotransmission	p. 163
Pharmacology of dopaminergic neurotransmission	p. 185
Pharmacology of serotonergic and central adrenergic neurotransmission	p. 207
Pharmacology of abnormal electrical neurotransmission in the central nervous system	p. 225
General anesthetic pharmacology	p. 239
Pharmacology of analgesia	p. 263
Pharmacology of drug dependence and addiction	p. 283
Principles of cardiovascular pharmacology	p. 305
Pharmacology of cardiac rhythm	p. 307
Pharmacology of cardiac contractility	p. 329
Pharmacology of volume regulation	p. 345
Pharmacology of vascular tone	p. 367
Pharmacology of hemostasis and thrombosis	p. 387
Pharmacology of cholesterol and lipoprotein metabolism	p. 417
Integrative cardiovascular pharmacology : hypertension, ischemic heart disease, and heart failure	p. 439
Principles of endocrine pharmacology	p. 467
Pharmacology of the hypothalamus and pituitary gland	p. 469
Pharmacology of the thyroid gland	p. 483
Pharmacology of the adrenal cortex	p. 493
Pharmacology of reproduction	p. 509
Pharmacology of the endocrine pancreas	p. 529
Pharmacology of bone mineral homeostasis	p. 547
Principles of chemotherapy	p. 565
Principles of antimicrobial and antineoplastic pharmacology	p. 567
Pharmacology of bacterial infections : DNA replication, transcription, and translation	p. 585
Pharmacology of bacterial infections : cell wall synthesis	p. 601
Pharmacology of fungal infections	p. 619
Pharmacology of parasitic infections	p. 631
Pharmacology of viral infections	p. 651
Pharmacology of cancer : genome synthesis, stability, and maintenance	p. 675
Pharmacology of cancer : signal transduction	p. 701
Principles of combination chemotherapy	p. 719
Principles of inflammation and immune pharmacology	p. 733
Principles of inflammation and the immune system	p. 735
Pharmacology of eicosanoids	p. 747
Histamine pharmacology	p. 769
Pharmacology of hematopoiesis and immunomodulation	p. 781
Pharmacology of immunosuppression	p. 795
Integrative inflammation pharmacology : peptic ulcer disease	p. 811
Integrative inflammation pharmacology : asthma	p. 825
Integrative inflammation pharmacology : gout	p. 841
Fundamentals of drug development and regulation	p. 849
Drug discovery and preclinical development	p. 851
Clinical drug evaluation and regulatory approval	p. 863
Systematic detection of adverse events in marketed drugs	p. 875
Poisoning by drugs and environmental toxins	p. 885
Poisoning by drugs and environmental toxins	p. 887
Frontiers in pharmacology	p. 907
Pharmacogenomics	p. 909
Protein-based therapies	p. 917
Drug delivery modalities	p. 935
Table of Contents provided by Blackwell. All Rights Reserved.

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