Principles and Practice of Psychopharmacotherapy

by Janicak, Philip G.; Davis, John M.; Preskorn, Sheldon H., M.D.; Ayd, Frank J., Jr.

• ISBN13: 9780683302660
• ISBN10: 0683302663
• Edition: 2nd
• Format: Hardcover
• Copyright: 1997-06-01
• Publisher: Williams & Wilkins

Summary

Completely updated in its Third Edition, this text provides an evidence-based approach to the clinical use of today's psychotropic drugs. The book comprehensively summarizes the scientific and clinical research literature and offers treatment strategies that flow directly from scientific data. The first chapter sets forth key principles of psychopharmacotherapy, foremost of which is the thorough assessment of the patient's history that helps establish the appropriate role of drug therapy. Subsequent chapters discuss the major categories of psychiatric drugs, present strategies for their therapeutic use, and discuss meta-analyses of clinical and scientific studies. Concluding chapters address anxiety disorders and special populations. Each chapter has user-friendly features such as highlighted/italicized text, tables, bulleted lists, and diagrams.

Table of Contents

Foreword	vii	(4)
Preface to the Second Edition	xi	(2)
Preface to the First Edition	xiii
1 General Principles	1	(30)
Principles of Psychopharmacotherapy	2	(6)
Role of Neuroscience	8	(2)
Diagnostic Assessment	10	(4)
Role of the Laboratory	14	(17)
2 Assessment of Drug Efficacy and Relevant Clinical Issues	31	(30)
Evaluation of Drug Study Designs	31	(6)
Statistical Summarization of Drug Studies	37	(8)
Patient Issues	45	(7)
Drug Management	52	(2)
Role of the Food and Drug Administration	54	(4)
Cost of Treatment	58	(3)
3 Pharmacokinetics	61	(24)
General Principles	61	(3)
Role of Pharmacokinetics	64	(1)
Alterations in Pharmacokinetics	65	(4)
The Four Primary Pharmacokinetic Phases	69	(8)
Therapeutic Drug Monitoring	77	(8)
4 Indications for Antipsychotics	85	(12)
Schizophrenia	85	(5)
Other Psychotic Disorders	90	(4)
Nonpsychotic Disorders	94	(3)
5 Treatment With Antipsychotics	97	(122)
History	97	(3)
Mechanism of Action	100	(7)
Effects on Cognition and Behavior	107	(3)
Management of Acute Psychosis	110	(30)
Maintenance/Prophylaxis	140	(15)
Long-Acting Antipsychotics	155	(5)
Pharmacokinetics/Plasma Levels	160	(12)
Alternative Treatment Strategies	172	(10)
Role of Psychosocial Therapies	182	(6)
Adverse Effects	188	(31)
6 Indications for Antidepressant Therapy	219	(24)
Depressive Disorders	219	(17)
Suicide	236	(6)
Other Costs of Major Depression	242	(1)
7 Treatment With Antidepressants	243	(114)
History	243	(2)
Mechanism of Action	245	(11)
Treatment Planning	256	(4)
Management of an Acute Depressive Episode	260	(35)
Maintenance/Prophylaxis	295	(7)
Pharmacokinetics	302	(4)
Therapeutic Drug Monitoring	306	(9)
Alternative Treatment Strategies	315	(4)
Role of Psychosocial Therapies	319	(2)
Adverse Effects	321	(36)
8 Treatment With Electroconvulsive Therapy and Other Somatic Therapies	357	(46)
Electroconvulsive Therapy	357	(25)
Experimental Somatic Therapies	382	(7)
9 Indications for Mood Stabilizers	389	(1)
Bipolar Disorder	389	(14)
10 Treatment With Mood Stabilizers	403	(72)
History	403	(2)
Mechanism of Action	405	(7)
Management of an Acute Manic Episode	412	(16)
Maintenance/Prophylaxis	428	(13)
Alternative Treatment Strategies	441	(20)
Adverse Effects of Lithium and Valproate	461	(9)
Adverse Effects of Other Drugs	470	(5)
11 Indications for Antianxiety and Sedative-Hypnotic Agents	475	(8)
Generalized Anxiety Disorder	475	(2)
Phobic Disorders	477	(1)
Psychological Factors Affecting Medical Condition	478	(1)
Sleep Disorders	479	(4)
12 Treatment With Antianxiety and Sedative-Hypnotic Agents	483	(54)
History	483	(2)
Mechanism of Action	485	(2)
Treatment of Generalized Anxiety Disorder	487	(8)
Treatment of Phobic Disorders	495	(2)
Treatment of Sleep Disorders	497	(12)
Pharmacokinetics	509	(3)
Adverse Effects of Anxiolytics	512	(13)
Adverse Effects of Sedative-Hypnotics	525	(12)
13 Assessment and Treatment of Other Disorders	537	(32)
Panic Disorder	537	(15)
Obsessive-Compulsive Disorder	552	(13)
Trichotillomania	565	(1)
Posttraumatic Stress Disorder	565	(4)
14 Assessment and Treatment of Special Populations	569	(82)
The Pregnant Patient	569	(4)
The Child and the Adolescent Patient	573	(21)
The Personality-Disordered Patient	594	(9)
The Elderly Patient	603	(15)
The Dying Patient	618	(5)
The Alcoholic Patient	623	(12)
The Human Immunodeficiency Virus-Infected Patient	635	(6)
The Eating-Disordered Patient	641	(6)
Conclusion	647	(4)
Appendices	651	(24)
Index	675