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9780824740832

Prions and Mad Cow Disease

by ;
  • ISBN13:

    9780824740832

  • ISBN10:

    0824740831

  • Format: Hardcover
  • Copyright: 2003-10-17
  • Publisher: CRC Press

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Summary

The alarm sounded by Canada's recently confirmed case of bovine spongiform encephalopathy (BSE) has reaffirmed the exigency of establishing improved safeguards and more aggressive surveillance protocols in North America and around the world. Research converging on the probable causative agent-prion proteins-calls for intensive assessment of the headway gained in tracing prions, testing for transmissible neurodegenerative diseases, and developing methods for cornering the epidemic. Administered by an illustrious panel of 36 international contributors, this timely book marshals techniques for prion protein assay and diagnosis of transmissible spongiform encephalopathies (TSEs).

Author Biography

Brian K. Nunnally is a Research Scientist at Eli Lilly and Company, Indianapolis, Indiana Ira S. Krull is Associate Professor of Chemistry at Northeastern University, Boston, Massachusetts

Table of Contents

Foreword iii
David C. Bolton
Preface ix
Contributors xiii
Taking Aim at the Transmissible Spongiform Encephalopathies Infectious Agents
1(20)
Richard I. Carp
Richard J. Kascsak
Prions, the Protein Hypothesis, and Scientific Revolutions
21(40)
David C. Bolton
A Simulation Model for Evaluating the Potential for Spread of Bovine Spongiform Encephalopathy in Animals or to People
61(64)
Joshua T. Cohen
Keith Duggar
George M. Gray
Silvia Kreindel
Hatim Gubara
Tsegaye HabteMariam
David Oryang
Berhanu Tameru
Actions to Prevent Bovine Spongiform Encephalopathy from Entering the United States
125(12)
Linda A. Detwiler
Burt Pritchett
Overview of Transmissible Spongiform Encephalopathy in Cervids in the United States
137(14)
Sam D. Holland
Bioassays for Prions
151(30)
Andrew F. Hill
Emmanuel A. Asante
John Collinge
Cyclic Amplification of Scrapie Prion Protein: Implications for Diagnosis
181(18)
Claudio Soto
The Enfer Transmissible Spongiform Encephalopathies Assay: Chemiluminescent ELISA of Prion Proteins
199(48)
Riona Sayers
Sensitive Detection of Prion Proteins by Immunoassay: CEA/Bio-Rad Test
247(30)
Emmanuel E. Comoy
Jacques Grassi
Jean-Philipe Deslys
The Diagnosis of Transmissible Spongiform Encephalopathies Using Differential Extraction and DELFIA
277(40)
Geoff Barnard
Man-Sun Sy
In Vivo Diagnosis of Prion Diseases
317(16)
Ruth Gabizon
Gideon M. Shaked
Diagnosis of Prion Diseases by Multispectral Techniques
333(26)
Richard Rubenstein
Perry C. Gray
Jae-Il Kim
Gary C. Tisone
Detection of the Prion Protein in Blood Using a Fluorescence Immunoassay
359(20)
Mary Jo Schmerr
Andrew Alpert
Prion Detection and Application to the Safety of Biological Products
379(34)
Jeanette L. C. Miller
Christopher J. Stenland
Stephen R. Petteway, Jr.
Douglas C. Lee
Index 413

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