Profiles of Drug Substances, Excipients and Related Methodology

by Brittain

• ISBN13: 9780123743404
• ISBN10: 0123743400
• Edition: 1st
• Format: Hardcover
• Copyright: 2009-02-17
• Publisher: Elsevier Science

Summary

Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients. * Presents comprehensive reviews covering all aspects of drug development and formulation of drugs * Profiles creatine monohydrate and fexofenadine hydrochloride, as well as five others * Meets the information needs of the drug development community

Table of Contents

Preface	p. ix
Creatine Monohydrate	p. 1
History and Therapeutic Aspects	p. 2
Description	p. 4
Synthesis	p. 5
Physical Properties	p. 8
Methods of Analysis	p. 23
Stability and Degradation	p. 27
Pharmacokinetics, Metabolism, and Toxicity	p. 28
Acknowledgments	p. 32
References	p. 32
Cytarabine	p. 37
Description	p. 38
Methods of Preparation	p. 41
Physical Characteristics	p. 47
Methods of Analysis	p. 54
Radioimmunoassay	p. 95
Biological Analysis	p. 98
Stability	p. 100
Pharmacokinetics, Metabolism, and Excretion	p. 102
Pharmacology	p. 104
Acknowledgments	p. 110
References	p. 110
Famotidine	p. 115
General Information	p. 116
Physical Characteristics	p. 117
Stability and Storage	p. 125
Analytical Profiles of Famotidine	p. 126
Drug Metabolism and Pharmacokinetic Profiles of Famotidine	p. 144
References	p. 150
Fexofenadine Hydrochloride	p. 153
Description	p. 154
Methods of Preparation	p. 156
Physical Properties	p. 161
Methods of Analysis	p. 175
Stability	p. 188
Drug Metabolism and Pharmacokinetics	p. 189
Acknowledgments	p. 190
References	p. 190
Itraconazole: Comprehensive Profile	p. 193
Description	p. 194
Physical Characteristics	p. 196
Uses and Applications	p. 205
Methods of Chemical Synthesis	p. 205
Methods of Analysis	p. 217
Food and Drug Interaction	p. 251
Stability	p. 253
Pharmacokinetics	p. 254
Absorption, Metabolism, and Excretion	p. 260
Acknowledgment	p. 261
References	p. 261
Ofloxacin	p. 265
Physical Profiles of Ofloxacin	p. 266
Analytical Profiles of Ofloxacin	p. 276
Drug Metabolism and Pharmacokinetic Profiles of Ofloxacin	p. 293
References	p. 296
Paclitaxel	p. 299
Introduction	p. 301
Description	p. 307
Methods of Preparation	p. 309
Physical Properties	p. 312
Method of Analysis	p. 321
Stability	p. 324
Pharmacokinetics and Metabolism	p. 328
Acknowledgment	p. 339
References	p. 339
Cumulative Index	p. 345
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