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9780444510549

Progress in Medicinal Chemistry

by ;
  • ISBN13:

    9780444510549

  • ISBN10:

    0444510540

  • Edition: 1st
  • Format: Hardcover
  • Copyright: 2002-09-25
  • Publisher: Elsevier Science
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Summary

The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a??quality lead???, where these??quality leads??? come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.*Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect

Table of Contents

Preface vii
List of Contributors
ix
The Discovery and Development of Atorvastatin, a Potent Novel Hypolipidemic Agent
1(22)
B.D. Roth
Discovery of CEP-1347/KT-7515, an Inhibitor of the JNK/SAPK Pathway for the Treatment of Neurodegenerative Diseases
23(40)
M.S. Saporito
R.L. Hudkins
A.C. Maroney
Discovery of Second Generation Quinazolinone Non-Nucleoside Reverse Transcriptase Inhibitors of HIV-1
63(44)
J.W. Corbett
J.D. Rodgers
Molecular Modeling of Opioid Receptor-Ligand Complexes
107(30)
I. McFadyen
T. Metzger
G. Subramanian
G. Poda
E. Jorvig
D.M. Ferguson
Subject Index 137(2)
Author Index (Vols. 1--40) 139(6)
Subject Index (Vols. 1--40) 145

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