Progress in Medicinal Chemistry

by King, F. D.; Oxford, A. W.

• ISBN13: 9780444500908
• ISBN10: 0444500901
• Format: Hardcover
• Copyright: 1999-06-01
• Publisher: Elsevier Science Serials

Summary

The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a??quality lead???, where these??quality leads??? come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.*Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect

Table of Contents

Preface	v
Influenza Virus Sialidase: A Target for Drug Discovery	1	(28)
Milton J. Kiefel
Mark von Itzstein
Department of Medicinal Chemistry, Monash University, Parkville Campus, 381 Royal Parade, Parkville, Victoria, 3052, Australia
Fibrinogen Receptor Antagonists: Design and Clinical Applications	29	(62)
Colin D. Eldred
Brian D. Judkins
Receptor Chemistry 2 Department, Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SGI 2NY, U.K.
Combinatorial Chemistry as a Tool for Drug Discovery	91	(78)
C.D. Floyd
C. Leblanc
M. Whittaker
British Biotech Pharmaceuticals Limited, Watlington Road, Oxford, OX4 5LY, U.K.
New Directions in Anxiolytic Drug Research	169	(32)
Malcolm K. Scott
David A. Demeter
Samuel O. Nortey
Barry Dubinsky
Richard P. Shank
Allen B. Reitz
Drug Discovery Division, R. W. Johnson Pharmaceutical Research Institute, Welsh and McKean Roads, Spring House, Pennsylvania 19477, U.S.A.
Selective Inhibitors of Cyclooxygenase-2 (COX-2)	201	(34)
John J. Talley
Discovery Medicinal Chemistry, G.D. Searle, a Division of Monsanto, 700 Chesterfield Parkway North, St. Louis, MO 63198, U.S.A.
Molecularly Imprinted Polymers - Preparation, Biomedical Applications and Technical Challenges	235	(58)
Christopher J. Allender
Keith R. Brain
Charles M. Heard
Regio & Enantio Selective Interactions Science & Technology Group, The Welsh School of Pharmacy, Cardiff University, CFI 3XF, U.K.
Subject Index	293	(6)
Author Index (Vols. 1-36)	299	(6)
Subject Index (Vols. 1-36)	305