Progress in Nucleic Acid Research and Molecular Biology

by Moldave

• ISBN13: 9780125400671
• ISBN10: 0125400675
• Edition: 1st
• Format: Hardcover
• Copyright: 2001-08-16
• Publisher: Elsevier Science

Summary

Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

Table of Contents

Some Articles Planned for Future Volumes	ix
The Molecular Biology of the Group VIA Ca2+ -Independent Phospholipase A2	1	(34)
Zhongmin Ma
John Turk
Introduction	2	(1)
Classification and Nomenclature	3	(1)
Sequence and Structural Characteristics	4	(13)
Gene Structure, Alternative, Splicing, and Chromosomal Localization	17	(3)
Tissue Distribution and Expression	20	(1)
Enzymology of Group VIA PLA2	20	(2)
Potential Cellular Functions	22	(6)
Future Perspectives	28	(7)
References	29	(6)
CooA: A Heme-Containing Regulatory Protein That Serves as a Specific Sensor of Both Carbon Monoxide and Redox State	35	(30)
Gary P. Roberts
Marc V. Thorsteinsson
Robert L. Kerby
William N. Lanzilotta
Thomas Poulos
Introduction	36	(1)
CO Oxidation by Rhodospirillum rubrum and Other Microorganisms	36	(2)
The coo Genes and Their Regulation	38	(2)
General Behavior of CooA as a Transcriptional Activator Responding to the Redox State and the Presence of CO	40	(2)
The Structure of CooA and Its Implications	42	(10)
CooA as a Redox Sensor	52	(1)
CooA as a CO Sensor	53	(1)
Cooperativity of Ligand Binding	54	(2)
Transcriptional Activation by CooA	56	(2)
DNA Recognition Properties of CooA	58	(1)
Future Direction and Open Questions	59	(6)
References	60	(5)
The msDNAs of Bacteria	65	(28)
Bert Lampson
Masayori Inouye
Sumiko Inouye
The Structure of msDNA	66	(5)
The Retron: A Genetic Element That Codes for the Production of msDNA	71	(4)
Synthesis of msDNA by Reverse Transcription	75	(5)
Bacterial Reverse Transcriptase	80	(2)
Prevalence, Diversity, and Origin of msDNA	82	(2)
msDNA and the Host Cell	84	(2)
Potential Uses for msDNA	86	(2)
Concluding Remarks	88	(5)
References	89	(4)
Cisplatin: From DNA Damage to Cancer Chemotherapy	93	(38)
Seth M. Cohen
Stephen J. Lippard
Background	94	(4)
Kinetic and Thermodynamic Aspects of Protein Binding to Cisplatin-DNA Adducts	98	(6)
Structure of an HMG Domain-Cisplatin-DNA Ternary Complex	104	(8)
Other Consequences of Cisplatin Treatment of Cells	112	(5)
Development of New Platinum Compounds	117	(8)
Concluding Remarks	125	(6)
References	126	(5)
Molecular and Cellular Biology of the Human Reduced Folate Carrier	131	(32)
Larry H. Matherly
Introduction	132	(1)
Background: Folate Metabolism and the Biochemical Rationale for Folate Antagonists as Anticancer Drugs	133	(5)
Functional Properties of RFC	138	(1)
Properties of the hRFC Protein and Isolation and Characterization of hRFC cDNAs	139	(8)
Transcriptional and Posttranscriptional Regulation of hRFC Expression	147	(6)
Molecular Mechanisms of Transport-Mediated MTX Resistance	153	(4)
Concluding Remarks	157	(6)
References	158	(5)
Gene Targeting via Triple-Helix Formation	163	(30)
Brian P. Casey
Peter M. Glazer
General Problems in Oligonucleotide-Based Gene Therapy Strategies	164	(1)
Delivery of Triplex-Forming Molecules	164	(2)
Minor-Groove Binders	166	(1)
Peptide Nucleic Acids	166	(1)
Basic Chemistry of TFOs	167	(3)
Improvements in TFO Chemistry	170	(2)
TFOs as Molecular Tools	172	(2)
The Chromatin Barrier	174	(3)
TFOs as Antigene Agents	177	(1)
TFO-Mediated Upregulation of Gene Expression	178	(2)
TFO-Mediated Mutagenesis	180	(1)
TFO-Mediated Recombinations	181	(4)
TFO-Directed Sequence Change	185	(1)
Repair Systems Implicated in TFO-Induced DNA Alterations	185	(3)
Conclusion	188	(5)
References	189	(4)
Searching New Targets for Anticancer Drug Design: The Families of Ras and Rho GTOaes and Their Effectors	193	(42)
Salvador Aznar
Juan Carlos Lacal
Rho Proteins and Their Effectors	196	(13)
Ras Proteins and Their Effectors	209	(6)
Pharmacological Approaches to Reverting Transformation by GTPases of the Rs and Rho Families	215	(8)
Future Perspectives	223	(12)
References	223	(12)
Major Histocompatibility Class I Folding, Assembly, and Degradation: A Paradigm for Two-Stage Quality Control in the Endoplasmic Reticulum	235	(34)
Mark R. Farmery
Neil J. Bulleid
Introduction	236	(3)
Primary Quality Control of Glycoprotein Folding in the ER	239	(8)
Secondary Mechanisms and Protein-Specific Quality Controls	247	(2)
Quality Control in the ER: General Considerations	249	(3)
Quality Control and MHC Class I Folding and Assembly	252	(11)
Conclusions and Perspectives	263	(6)
References	264	(5)
Index	269