Progress in Nucleic Acid Research and Molecular Biology

by Moldave

• ISBN13: 9780125400725
• ISBN10: 0125400721
• Edition: 1st
• Format: Hardcover
• Copyright: 2002-07-31
• Publisher: Elsevier Science

Summary

Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

Table of Contents

Some Articles Planned for Future Volumes	ix
Viral Strategies of Translation Initiation: Ribosomal Shunt and Reinitiation	1	(40)
Lyubov A. Ryabova
Mikhail Pooggin
Thomas Hohn
Introduction	2	(2)
Main Initiation Strategies in Eukaryotes	4	(3)
Translation and Translation-Dependent Strategies of Pararetroviruses and Retroviroses	7	(5)
Shunting Mechanisms	12	(9)
Polycistronic Translation Strategies	21	(7)
Outlook	28	(13)
References	29	(12)
Initiation of Eukaryotic DNA Replication: Regulation and Mechanisms	41	(54)
Heinz-Peter Nasheuer
Richard Smith
Christina Bauerschmidt
Frank Grosse
Klaus Weisshart
The Eukaryotic Cell Cycle	42	(11)
Factors Required for the Initiation of DNA Replication	53	(16)
The Organization of Replication-Initiation Factors on Chromatin	69	(4)
Cell Cycle Control by Checkpoints	73	(7)
Outlook	80	(15)
References	81	(14)
Deoxyribonucleotide Synthesis in Anaerobic Microorganisms: The Class III Ribonucleotide Reductase	95	(34)
Mare Fontecave
Etienne Mulliez
Derek T. Logan
Introduction	96	(3)
The Anaerobic Ribonucleotide Reductase: A Multicomponent System	99	(1)
The nrdD Protein: The Reductase Component	99	(15)
The nrdG Protein: The Activase	114	(6)
Gene Organization and Regulation	120	(1)
The Anaerobic RNR: The Link between the RNA World and the DNA World	120	(9)
References	125	(4)
Regulation of Pathways of mRNA Destabilization and Stabilization	129	(36)
Robin E. Dodson
David J. Shapiro
Life and Half Life of mRNA	130	(1)
Degradation of mRNA through the General Pathway; Deadenylation-Dependent mRNA Decay	131	(2)
Special Pathways for Regulating the Stability of mRNAs	133	(9)
Regulation of Vitellogenin and Albumin mRNA Stability	142	(23)
References	159	(6)
Jasmonates and Octadecanoids: Signals in Plant Stress Responses and Development	165	(58)
Claus Wasternack
Bettina Hause
Introduction	166	(2)
Occurrence of Jasmonates and Octadecanoids	168	(3)
Biosynthesis of Jasmonates and Octadecanoids	171	(9)
Jasmonate-Induced Gene Expression	180	(5)
Jasmonates in Stress Response and Signal Transduction Pathways	185	(11)
Jasmonates and Octadecanoids in Plant Development	196	(9)
Concluding Remarks	205	(18)
References	206	(17)
The Ubiquitous Nature of RNA Chaperone Proteins	223	(46)
Gael Cristofari
Jean-Luc Darlix
Introduction	224	(2)
RNA Structure and the Folding Problem	226	(3)
RNA-Binding Proteins	229	(5)
Investigating the Biochemical Properties of Nucleic Acid Chaperone Proteins	234	(12)
How Do RNA Chaperone Proteins Work?	246	(12)
Conclusions and Future Prospects	258	(11)
References	263	(6)
Mechanisms of Basal and Kinase-Inducible Transcription Activation by CREB	269	(38)
Patrick G. Quinn
Introduction	270	(2)
Distinct CREB Activation Domains Mediate Constitutive and Kinase-Inducible Transcription	272	(12)
A Concerted Mechanism of Transcription Activation Involving Stimulation of Sequential Steps in Transcription Initiation by the CAD and P-KID	284	(14)
Perspectives	298	(9)
References	299	(8)
eIF4A: The Godfather of the DEAD Box Helicases	307	(26)
George W Rogers, Jr.
Anton A. Komar
William C. Merrick
eIF4A: The Protein	308	(4)
The Biology of eIF4A	312	(1)
eIF4A: Biochemical Properties	313	(6)
Influence of Other Proteins on eIF4A Function	319	(2)
Does Any of This Biochemistry Make Sense or Is There a Contradiction Somewhere?	321	(2)
The Role of the DEAD Box Sequences	323	(1)
The Function of the Helicase Activity of eIF4A	324	(2)
eIF4A and the 80S Initiation Pathway	326	(2)
Lessons Learned from eIF4A	328	(5)
References	329	(4)
CTD Phosphatase: Role in RNA Polymerase II Cycling and the Regulation of Transcript Elongation	333	(34)
Patrick S. Lin
Nicholas E Marshall
Michael E. Dahmus
Historical Overview	334	(3)
General Properties of CTD Phosphatase	337	(9)
RNAP II Recycling Mediated by CTD Phosphatase	346	(3)
Involvement of CTD Phosphatase in the Regulation of Transcript Elongation	349	(8)
Perspectives and Future Directions	357	(10)
References	359	(8)
Translational Control of Gene Expression: Role of IRESs and Consequences for Cell Transformation and Angiogenesis	367	(48)
Anne-Catherine Prats
Herve Prats
Introduction	369	(2)
Background: Translation Initiation in Eukaryotes	371	(7)
The Murine Leukemia Virus: The Retroviral Genomic mRNA Codes for Two Gag-Pol Polyproteins from Two CUG and AUG Initiation Codons	378	(5)
The FGF-2 mRNA: How Cap-Dependent and IRES-Dependent Translation of a Single mRNA Leads to Expression of Five Isoforms with Distinct Localizations and Functions	383	(10)
VEGF mRNA: Two Distinct IRESs Control Alternative Initiation of the Translation of Two Isoforms	393	(3)
C-myc mRNA: A Natural Multicistronic Messenger	396	(2)
IRES-Dependent Translational Control: IRES Activity Enhancement in Transformed Cells	398	(1)
IRES Tissue Specificity in Vivo	399	(1)
FGF-2 Translational Silencing by Tumor Suppressor p53	400	(3)
Concluding Remarks	403	(12)
References	405	(10)
Structure and Function of φ29 Hexameric RNA That Drives the Viral DNA-Packaging Motor: Review	415	(58)
Peixuan Guo
Introduction	416	(3)
Approaches and Strategies for the Study of pRNA	419	(11)
Studies of pRNA Structure	430	(15)
pRNA-Protein Interactions	445	(3)
Effect of Mono- and Divalent Cations on pRNA Dimer Formation, Procapsid Binding and Viral Assembly	448	(1)
Functions of pRNA	449	(8)
Significance and Application of the Study of pRNA	457	(4)
Concluding Remarks	461	(12)
References	462	(11)
Index	473