Progress in Nucleic Acid Research and Molecular Biology

by Moldave

• ISBN13: 9780125400756
• ISBN10: 0125400756
• Format: Hardcover
• Copyright: 2003-10-10
• Publisher: Elsevier Science

Summary

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.

Table of Contents

Some Articles Planned for Future Volumes	ix
Molecular Regulation, Evolutionary, and Functional Adaptations Associated with C to U Editing of Mammalian ApolipoproteinB mRNA	1	(42)
Shrikant Anant
Valerie Blanc
Nicholas O. Davidson
RNA Editing: General Overview of Underlying Biochemical Mechanisms and Evolutionary Development	2	(3)
C to U RNA Editing	5	(9)
C to U ApoB RNA Editing: cis-Acting Elements	14	(3)
C to U ApoB RNA Editing: trans-Acting Factors	17	(16)
Summary	33	(10)
Acknowledgments	33	(1)
References	33	(10)
Polymorphisms in the Genes Encoding Members of the Tristetraprolin Family of Human Tandem CCCH Zinc Finger Proteins	43	(26)
Perry J. Blackshear
Ruth S. Phillips
Johana Vazquez-Matias
Harvey Mohrenweiser
Introduction	44	(1)
Materials and Methods	45	(7)
Results	52	(11)
Discussion	63	(6)
Acknowledgments	66	(1)
References	66	(3)
Molecular and Cell Biology of Phosphatidylserine and Phosphatidylethanolamine Metabolism	69	(44)
Jean E. Vance
Membrane Phospholipids	70	(1)
Pathways for Biosynthesis of Phosphatidylserine and Phosphatidylethanolamine	71	(3)
Enzymes of Phosphatidylserine Biosynthesis	74	(8)
Enzymes of Phosphatidylethanolamine Biosynthesis	82	(3)
Regulation of PS and PE Biosynthesis	85	(2)
Interorganelle Transport of PS and PE	87	(5)
Intramembrane Transport of PS and PE	92	(3)
Biological Functions of PS and PE	95	(2)
Future Directions	97	(16)
References	98	(15)
DNA-Protein Interactions during the Initiation and Termination of Plasmid pT181 Rolling-Circle Replication	113	(26)
Saleem A. Khan
Introduction	114	(2)
Origins of Replication of the Plasmids of the pT181 Family	116	(6)
Initiator Proteins of the Plasmid pT181 Family	122	(4)
Mechanism of Inactivation of the Plasmid pT181 Family Rep Proteins	126	(3)
Role of Host Proteins in pT181 RC Replication	129	(3)
Replication of the Lagging Strand of Plasmid pT181	132	(1)
Conclusions and Future Directions	133	(6)
Acknowledgments	133	(1)
References	133	(6)
Herpes Simplex Virus Type-1: A Model for Genome Transactions	139	(34)
Paul E. Boehmer
Giuseppe Villani
Introduction to Herpesviridae	140	(1)
HSV-1 Life Cycle, Genome Structure, and Replication Genes	140	(4)
Initiation of Replication	144	(7)
Elongation	151	(4)
Interaction of the HSV-1 DNA Replication Machinery with DNA Damage	155	(4)
Homologous Recombination	159	(4)
Concluding Remarks	163	(10)
Acknowledgments	165	(1)
References	165	(8)
Enzymology and Molecular Biology of Glucocorticoid Metabolism in Humans	173	(44)
Andreas Blum
Edmund Maser
Introduction	174	(1)
Glucocorticoid Action	175	(2)
The Free Hormone Hypothesis	177	(1)
Glucocorticoid Receptors	178	(1)
Nongenomic Action of Glucocorticoids	179	(1)
Glucocorticoid Resistance	180	(1)
11β-Hydroxysteroid Dehydrogenase (11β-HSD) as Prereceptor Control	181	(1)
Hydroxysteroid Dehydrogenases: Physiological Role	182	(1)
The History of Two Isoforms: 11β-HSD Type 1 and 11β-HSD Type 2	182	(1)
A (Patho)physiological Role for 11β-HSD 1 and 11β-HSD 2	183	(1)
11β-HSD 2 and the Syndrome of ``Apparent Mineralocorticoid Excess'' (AME)	184	(3)
11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD 1)	187	(16)
Conclusions	203	(14)
References	203	(14)
Dancing with Complement C4 and the RP-C4-CYP21-TNX (RCCX) Modules of the Major Histocompatibility Complex	217	(76)
C. Yung Yu
Erwin K. Chung
Yan Yang
Carol A. Blanchong
Natalie Jacobsen
Kapil Saxena
Zhenyu Yang
Webb Miller
Lilian Varga
George Fust
Introduction	219	(2)
The Sophisticated Genetic Diversities of Human C4 and RCCX Modules	221	(11)
Structural Diversities of the Human and Mouse C4 Proteins	232	(13)
Nucleotide Polymorphisms in Human C4A and C4B Genes	245	(10)
Expression of C4A and C4B Transcripts and Proteins	255	(5)
The Endogenous Retrovirus that Mediates the Dichotomous Size Variation of C4 Genes	260	(7)
Evolution of Complement C3/C4/C5 and the RCCX Modules in the MHC	267	(7)
Afterthoughts: Eleven Outstanding Issues to be Addressed	274	(19)
Acknowledgments	276	(1)
References	276	(17)
The Roles and Regulation of Potassium in Bacteria	293	(28)
Wolfgang Epstein
Paths of K+ Movement	296	(9)
Regulation of K+ Transport Systems	305	(4)
K As An Intracellular Activator	309	(2)
Regulation of Internal pH by K+	311	(1)
Future Directions	312	(9)
References	313	(8)
Conformational Polymorphism of d(A-G)n and Related Oligonucleotide Sequences	321	(28)
Nina G. Dolinnaya
Jacques R. Fresco
Introduction	321	(2)
α-DNA Helix Acid-Dependent Duplex Equilibrium	323	(9)
Acid-Dependent Parallel Duplex pH-Independent Parallel Duplex Equilibrium	332	(2)
pH-Independent Parallel Duplex Single-Hairpin Duplex Two-Hairpin Tetraplex Equilibria	334	(8)
Concluding Remarks	342	(7)
Acknowledgments	344	(1)
References	344	(5)
Index	349