Progress in Nucleic Acid Research And Molecular Biology

by Moldave

• ISBN13: 9780125400800
• ISBN10: 0125400802
• Format: Hardcover
• Copyright: 2005-09-20
• Publisher: Elsevier Science

Summary

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.

Table of Contents

Some Articles Planned for Future Volumes	ix
Strand Selection by the Tyrosine Recombinases	1	(42)
Linda Lee
Paul D. Sadowski
Introduction	2	(2)
Classification and Functions of Conservative Site-Specific Recombinases	4	(1)
Cre Recombinase	5	(12)
Flp	17	(4)
XerCD Recombinase	21	(5)
λ Integrase	26	(4)
Discussion	30	(13)
References	33	(10)
Probing the Complex System of Metabolic Integration	43	(52)
Diana M. Downs
George E. Schmitz
Elizabeth Skovran
Introduction	45	(1)
Cellular Metabolism is a Complex System	45	(4)
Goals Toward Understanding Metabolism	49	(3)
Strategy to Dissect Metabolic Integration	52	(1)
Requirements to Dissect the Complex System of Metabolism	53	(2)
Thiamine Biosynthesis Provides a Means to Address Metabolic Integration	55	(5)
Mutations Indirectly Impacting Thiamine Synthesis, the Basis of Metabolic Integration	60	(2)
PRA Formation: Metabolic Suppression, Redundancy or Functional Overlap?	62	(4)
Conversion of AIR to HMP: Describing Components of a Complex System and Generating Functional Insight	66	(8)
Expanding the Network by Identifying New Nodes	74	(9)
Final Thoughts	83	(12)
References	85	(10)
Function, Structure, and Biogenesis of Mitochondrial ATP Synthase	95	(40)
Sharon H. Ackerman
Alexander Tzagoloff
Introduction	96	(1)
ATP Synthase Structure and Function	96	(7)
ATP Synthase, the Key Organizer of the Mitochondrial Inner Membrane	103	(3)
ATP Synthase Gene Expression	106	(5)
ATP Synthase Assembly: F1 Component	111	(7)
ATP Synthase Assembly: F0 Component	118	(5)
Conclusions	123	(12)
References	124	(11)
Virus-like Particles: Models for Assembly Studies and Foreign Epitope Carriers	135	(34)
Andrzej Palucha
Adrianna Loniewska
Subbian Satheshkumar
Anna M. Boguszewska-Chachulska
Mahadevaiah Umashankar
Malgorzata Milner
Anne-Lise Haennl
Handanahal Subbarao Savithri
Introduction	136	(1)
Requirements for VLP Assembly	136	(16)
VLPs as Epitope Carriers and Foreign Antigen Presentation Systems	152	(6)
Concluding Remarks	158	(11)
References	159	(10)
Regulation of Protease and Protease Inhibitor Gene Expression: The Role of the 3-UTR and Lessons from the Plasminogen Activating System	169	(48)
Stan Stasinopoulos
Hoanh Tran
Emily Chen
Mythily Sachchithananthan
Yoshikuni Nagamine
Robert L. Medcalf
Introduction	170	(5)
Post-Transcriptional Gene Regulation and General Perspectives	175	(11)
Post-Transcriptional Regulation of the Plasminogen Activating System	186	(8)
Modulation of Protease and Protease Inhibitor Gene Expression at the Level of 3 Pre-mRNA Processing and Translation	194	(2)
Conclusions	196	(21)
References	197	(20)
Nucleic Acid Chaperone Activity of HIV-1 Nucleocapsid Protein: Critical Role in Reverse Transcription and Molecular Mechanism	217	(70)
Judith G. Levin
Jianhui Guo
Ioulia Rouzina
Karin Musier-Forsyth
Introduction	218	(1)
Structure and Nucleic Acid Binding Properties of HIV-1 NC	219	(4)
NC Function in Reverse Transcription	223	(22)
Role of NC's Zinc Fingers	245	(6)
Mechanism of NC's Nucleic Acid Chaperone Activity	251	(12)
Concluding Remarks	263	(24)
References	265	(22)
Transcription in the Osteoblast: Regulatory Mechanisms Utilized by Parathyroid Hormone and Transforming Growth Factor-Beta	287	(36)
Christine E. Boumah
Nagarajan Selvamurugan
Nicola C. Partridge
Introduction	288	(1)
Regulation of Transcription by Parathyroid Hormone (PTH)	288	(15)
Summary of PTH Induction of MMP-13	303	(1)
Regulation of Transcription by Transforming Growth Factor-beta (TGF-β)	304	(5)
Summary of TGF-β Actions on MMP-13	309	(1)
Conclusions	310	(13)
References	311	(12)
Structure and Function in Promoter Escape by T7 RNA Polymerase	323	(26)
Craig T. Martin
Edward A. Esposito
Karsten Theis
Peng Gong
Introduction	324	(1)
Mapping the Transcription Bubbles at Initiation and During Elongation	325	(1)
Initial Collapse of the Bubble Occurs on Translocation Beyond Position +8	326	(3)
Promoter Release Occurs on Translocation Beyond Position +8	329	(2)
Initial RNA Displacement Occurs on Translocation Beyond Position +8	331	(1)
Bubble Collapse Contributes to Initial RNA Displacement	332	(5)
Retention of Promoter Contacts Interferes with Initial Bubble Collapse	337	(3)
Coupling of Promoter Release, Bubble Collapse, and RNA Displacement	340	(2)
A Structural Model for the Transition from Initiation to Elongation	342	(1)
Summary	343	(6)
References	344	(5)
Ribonuclease Inhibitor: Structure and Function	349	(26)
Kimberly A. Dickson
Marcia C. Haigis
Ronald T. Raines
Introduction	349	(1)
Biochemical Properties	350	(5)
Structure	355	(5)
Complexes with Ribonucleases	360	(3)
Cysteine Content and Oxidative Instability	363	(1)
Biological Activities	364	(3)
Conclusions	367	(8)
References	368	(7)
Index	375