Progress Toward Better Vaccines Proceedings at a meeting organized by the WHO as part of a program for vaccine development held in Bellagio Italy by courtesy of the Rockefeller Foundation 16-18 April 1985

by World Health Organization; Bell, Rosemary; Torrigiani, G.

• ISBN13: 9780192615671
• ISBN10: 019261567X
• Format: Hardcover
• Copyright: 1987-02-26
• Publisher: Oxford University Press

Summary

The development of new or improved vaccines using biotechnological techniques is especially important for developing countries, where traditional means of vaccine manufacture are frequently not available. This volume explores the four main approaches for developing alternative vaccines: the use of live agents; the use of anti-idiotype antibodies; the introduction of DNA or cDNA coding for a protective antigen of the disease agent into a mammalian cell line, into a lower eukaryote, or into an appropriate bacterium; and the synthesis of oligopeptides corresponding to an epitope or a protective antigen of the disease agent.

Table of Contents

Introduction

Recognition of Antigen by T Cells

Suppression Mechanism

Excessive Number of L3T4+ Parasite-Specific T Lymphocytes Capable of Mediating Specific Delayed-Type Hypersensitivity in Lymphoid Tissues of Genetically Susceptible (BALB/c) Mice Infected with Leishmania Major

IgA Synthesis and Stimulation

The Role of Lymphokines in T-Cell Activation and Effector Functions

Cellular and Molecular Aspects of the Genetic Control of the T-Cell Response to a Defined Protein Epitope

Locating Immunogenic Sites on Viral Proteins

Anti-Idiotypic Vaccines

Mutual Conformational Adjustments of Ligand and Protein Upon Binding

Membrane Proteins as Micelles or Iscoms in Vaccination Experiments

Directional T to B Help in the Immune Response to Conformational Determinants in a Multimeric Protein

An Infertility Vaccine

Role and Potentiation of Different Classes of Antigen-Presenting Cells

Myelopeptides - Regulatory Bone Marrow Mediators

Mineral Gel Adjuvants: Why Has It Taken So Long to Find an Alternative?

Muramyl Dipeptides and Analogues

Continuous and Pulsed Delivery of Bioactive Materials Using Composite Systems Based on Inorganic Glasses

Discussion: Peptide-Based Vaccines

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