Prokaryotic Antimicrobial Peptides

by Drider, Djamel; Rebuffat, Sylvie

• ISBN13: 9781441976918
• ISBN10: 1441976914
• Format: Hardcover
• Copyright: 2011-02-23
• Publisher: Springer Verlag

Summary

The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors' opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.

Author Biography

Dr. Djamel Drider is currently an associate professor of Microbiology at Nantes-Atlantic National College of Veterinary Medicine, Food Science and Engineering-Onaris. He obtained his PhD from Ecole Nationale Suprieure Agronomique de Montpellier (France) and completed his post-doc at Centro de Investigaciones Biolgicas (Madrid, Spain) and Mount Sinai School of Medicine at New York University. Dr. Drider is Currently a member of the editorial board of the journal, Probiotics and Antimicrobial Proteins and Chairman of the French Antimicrobial Peptides Society. Professor Sylvie Rebuffat is the Director of the Laboratory Communication Molecules and Adaptation of Microorganisms at the National Museum of Nalural History in Paris, France. She researches antimicrobial peptides of bacterial origin (microcins, bacteriocins), focusing mainly on their mechanisms of action, structure/activity relationships, and biosynthetic pathways. Dr. Rebuffat is also the Scientific Advisor to the Director of the National Museum of Natural History.

Table of Contents

Introduction: History, Current Knowledge, and Future Research on Antimicrobial Peptides
History, Current Knowledge, and Future Directions on Bacteriocin Research in Lactic Acid Bacteria	p. 3
Bacteriocin-Mediated Competitive Interactions of Bacterial Populations and Communities	p. 13
Classification of Prokaryotic Antimicrobial Peptides
Classification of Bacteriocins from Gram-Positive Bacteria	p. 29
Bacteriocins from Gram-Negative Bacteria: A Classification?	p. 55
Isolation, Purification, and Production of Antimicrobial Peptides
Genome Exploitation and Bioinformatics Tools	p. 75
Design and Engineering Strategies for Synthetic Antimicrobial Peptides	p. 81
Purification Techniques of Bacteriocins from Lactic Acid Bacteria and Other Gram-Positive Bacteria	p. 99
Natural and Heterologous Production of Bacteriocins	p. 115
Genetics, Biosynthesis, Structure, and Mode of Action of AMP from Gram-Positive Bacteria
Genetics, Biosynthesis, Structure, and Mode of Action of Lantibiotics	p. 147
Class IIa Bacteriocins: Current Knowledge and Perspectives	p. 171
The Two-Peptide (Class-lib) Bacteriocins: Genetics, Biosynthesis, Structure, and Mode of Action	p. 197
Class IIc or Circular Bacteriocins	p. 213
Class IId or Linear and Non-Pediocin-Like Bacteriocins	p. 237
Genetics, Biosynthesis, Structure, and Mode of Action of AMP from Gram-Negative Bacteria
Colicin Killing: Foiled Cell Defense and Hijacked Cell Functions	p. 255
Class I Microcins: Their Structures, Activities, and Mechanisms of Resistance	p. 289
Class II Microcins	p. 309
Microcins from Enterobacteria: On the Edge Between Gram-Positive Bacteriocins and Colicins	p. 333
Applications and Perspectives
Food Applications and Regulation	p. 353
Medical and Personal Care Applications of Bacteriocins Produced by Lactic Acid Bacteria	p. 391
Perspectives and Peptides of the Next Generation	p. 423
Index	p. 441
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