Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies

by Sewell; Robert D. E.

• ISBN13: 9780849373107
• ISBN10: 0849373107
• Edition: 1st
• Format: Hardcover
• Copyright: 2007-12-03
• Publisher: CRC Press

Summary

Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact. Protein Misfolding inNeurodegenerative Diseases: Mechanisms and Therapeutic Strategiesaddresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding andnovel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS. A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein MisfoldingDivided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimera??s, Parkinsona??s, Huntingtona??s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.

Table of Contents

Introduction

Protein Folding

Alzheimer's Disease

Alzheimer's Disease: Epidemiology, symptoms and clinical pathology

Improving Cholinergic Transmission

Reduction in Plaque Formation

Carbonic Anhydrase Activation

Reduction of Intracellular Neurofibrillary Tangles from Tau Protein

Oxidative Stress Reduction

Enhancement of Brain Retinoic Acid Levels

Sulfatase Inhibitors and Cognitive Enchancement

Parkinson's Disease

Epidemiology, Symptoms and Clinical Pathology

Restoring Dopamine Levels

Anticholinergics

Rarer Neurodegenerative Diseases

Huntington's Disease

Amyotrophic Lateral Sclerosis (Motor Neurone Disease)

Transmissible Spongiform Encephalopathies (TSEs) - Bovine Spongiform Encephalopathy (BSE) - Creutzfeldt-Jacob Disease (CJD, vCJD) - Scrapie

Overview - Common Role of Protein Misfolding in Neurodegenerative Diseases

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