Protein Structure Prediction A Practical Approach

by Sternberg, Michael J. E.

• ISBN13: 9780199634965
• ISBN10: 0199634963
• Format: Paperback
• Copyright: 1997-01-30
• Publisher: IRL Press

Summary

The prediction of the three-dimensional structure of a protein from its amino acid sequence is a problem faced by an increasing number of biological scientists. This book provides a practical guide to making these predictions by reviewing strategies of different computer modeling algorithms and highlighting the degree of confidence attributed to them. Also in the volume are descriptions of the following: the principles of protein folding; sequence homology and motif searches; prediction of secondary structure; homology modeling; modeling of antibody combining sites; tertiary fold recognition; modeling of transmembrane proteins; ab initio prediction; protein-ligand docking simulations; and the use of molecular mechanics and dynamics. both non-specialists who require guidance to identify and evaluate appropriate strategies and experts who require a contemporary view of the field, will find this volume a worthy addition to their research libraries.

Table of Contents

Protein structure prediction - principles and approaches

Protein sequence alignment and database scanning

Identification of protein sequence motifs

Prediction of secondary structure

Prediction of transmembrane protein topology

Comparative modelling of proteins

Antibody combining sites: structure and prediction

Protein folds and their recognition from sequence

The combinatorial approach

Modelling protein conformation by molecular mechanics and dynamics

Docking ligands to proteins

The prediction challenge

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