Protein Structure Prediction A Practical Approach

by Sternberg, Michael J. E.

• ISBN13: 9780199634972
• ISBN10: 0199634971
• Format: Hardcover
• Copyright: 1997-01-30
• Publisher: Oxford University Press

Summary

The prediction of the three-dimensional structure of a protein from its sequence is a problem faced by an ever-increasing number of biological scientists as they strive to utilize genetic information. The increasing sizes of the sequence and structural databases, the improvements in computingpower, and the deeper understanding of the principles of protein structure have led to major developments in the field in the last few years. This book presents practical computer-based methods using the latest computer modelling algorithms.

Table of Contents

Protein structure prediction - principles and approaches

Protein sequence alignment and database scanning

Identification of protein sequence motifs

Prediction of secondary structure

Prediction of transmembrane protein topology

Comparative modelling of proteins

Antibody combining sites: structure and prediction

Protein folds and their recognition from sequence

The combinatorial approach

Modelling protein conformation by molecular mechanics and dynamics

Docking ligands to proteins

The prediction challenge

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