Psychiatric Genetics and Genomics

by McGuffin, Peter; Owen, Michael J.; Gottesman, Irving I

• ISBN13: 9780198564867
• ISBN10: 0198564864
• Format: Paperback
• Copyright: 2004-11-18
• Publisher: Oxford University Press

Summary

Genetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book presents a critical review of the evidence for a genetic contribution to common psychiatric conditions and the rarer single-gene disorders that may have psychiatric presentations The first section of the book introduces the reader to molecular biology and the techniques of molecular genetics. The coverage then moves on to consider the genetics of normal and abnormal development, followed by a look at the genetics of abnormal behaviour in adults. This section includes, amongst others, consideration of personality disorders, schizophrenia and the dementias. The final section considers the applications of the work and covers issues such as counselling and ethics, closing with a look to the future. The editors are internationally renowned figures in this field and they have invited a team of equally eminent chapter authors. This will be essential reading for psychiatrists and geneticists and will be essential reading for psychiatrists and geneticists and will be of interest to neurologists, psychologists and neuroscientists.

Table of Contents

List of contributors	ix
Part 1 Basic principles
Basic molecular genetics	3	(28)
Michael C. O'Donovan
Michael J. Owen
Quantitative genetics	31	(24)
Alastair Cardno
Peter McGuffin
Linkage and association	55	(22)
Pak Sham
Peter McGuffin
Part 2 The genetics of normal and abnormal development
Personality and cognitive abilities	77	(36)
Robert Plomin
Francesca Happe
Avshalom Caspi
Genetics of mental retardation	113	(16)
Anita Thapar
Jill Clayton-Smith
Reading and language disorders	129	(18)
Julie Williams
Childhood disorders	147	(36)
Anita Thapar
Jane Scourfield
Part 3 The genetics of abnormal behaviour in adult life
Personality disorders	183	(28)
Peter McGuffin
Terrie Moffitt
Anita Thapar
Genetics of affective disorders	211	(36)
Ian Jones
Lindsey Kent
Nick Craddock
Schizophrenia	247	(20)
Michael J. Owen
Michael C. O'Donovan
Irving I. Gottesman
Substance misuse	267	(36)
David Ball
David Collier
Anxiety and eating disorders	303	(38)
Thalia C. Eley
David Collier
Peter McGuffin
The dementias	341	(56)
Malcolm B. Liddell
Julie Williams
Michael J. Owen
Part 4 Applications and implications
Psychopharmacogenetics	397	(22)
Rob W. Kerwin
Maria J. Arranz
Genetic counselling	419	(10)
Jane Scourfield
Michael J. Owen
Ethical considerations in psychiatric genetics	429	(20)
Anne Farmer
The future and post-genomic psychiatry	449	(16)
Michael J. Owen
Peter McGuffin
Irving I. Gottesman
Appendix 1: A brief guide to internet addresses for psychiatric genetics and genomics	465	(4)
Irving I. Gottesman
Appendix 2: Psychiatric genetics and genomics -- an update	469	(16)
Peter McGuffin
Michael J. Owen
Irving I. Gottesman
Index	485