Psychiatry, Psychoanalysis, and the New Biology of Mind

by Kandel, Eric R.

• ISBN13: 9781585621996
• ISBN10: 1585621994
• Edition: 1st
• Format: Hardcover
• Copyright: 2005-05-01
• Publisher: AMERICAN PSYCHIATRIC PUBLISHING INC

Summary

Brought together for the first time in a single volume, these eight important and fascinating essays by Nobel Prize-winning psychiatrist Eric Kandel provide a breakthrough perspective on how biology has influenced modern psychiatric thought. Complete with commentaries by experts in the field, Psychiatry, Psychoanalysis, and the New Biology of Mindreflects the author's evolving view of how biology has revolutionized psychiatry and psychology and how potentially could alter modern psychoanalytic thought. The author's unique perspective on both psychoanalysis and biological research has led to breakthroughs in our thinking about neurobiology, psychiatry, and psychoanalysis-all driven by the central idea that a fuller understanding of the biological processes of learning and memory can illuminate our understanding of behavior and its disorders. These wonderful essays cover the mechanisms of psychotherapy and medications, showing that both work at the same level of neural circuits and synapses, and the implications of neurobiological research for psychotherapy; the ability to detect functional changes in the brain after psychotherapy, which enables us, for the first time, to objectively evaluate the effects of psychotherapy on individual patients; the need for animal models of mental disorders; for example, learned fear, to show how molecules and cellular mechanisms for learning and memory can be combined in various ways to produce a range of adaptive and maladaptive behaviors; the unification of behavioral psychology, cognitive psychology, neuroscience, and molecular biology into the new science of the mind, charted in two seminal reports on neurobiology and molecular biology given in 1983 and 2000; the critical role of synapses and synaptic strength in both short- and long-term learning; the biological and social implications of the mapping of the human genome for medicine in general and for psychiatry and mental health in particular; The author concludes by calling for a revolution in psychiatry, one that can use the power of biology and cognitive psychology to treat the many mentally ill persons who do not benefit from drug therapy. Fascinating reading for psychiatrists, psychoanalysts, social workers, residents in psychiatry, and trainees in psychoanalysis, Psychiatry, Psychoanalysis, and the New Biology of Mindrecords with elegant precision the monumental changes taking place in psychiatric thinking. It is an invaluable reference work and a treasured resource for thinking about the future.

Author Biography

Eric R. Kandel, M.D., is University Professor at Columbia University, Fred Kavli Professor and Director at the Kavli Institute for Brain Sciences, and a Senior Investigator at Howard Hughes Medical Institute. A graduate of Harvard College and NYU School of Medicine, Dr. Kandel trained in Neurobiology at the NIH and in Psychiatry at Harvard Medical School. He joined the faculty of the College of Physicians and Surgeons at Columbia University in 1974 as the founding director of the Center for Neurobiology and Behavior.

Dr. Kandel's research has been concerned with the molecular mechanisms of memory storage in Aplysia and mice. Dr. Kandel has received thirteen honorary degrees, is a member of the U.S. National Academy of Sciences as well as the National Science Academies of Germany and France. He has been recognized with the Albert Lasker Award, the Heineken Award of the Netherlands, the Gairdner Award of Canada, the Wolf Prize of Israel, the National Medal of Science of the USA, and the Nobel Prize for Physiology or Medicine in 2000.

Table of Contents

CONTRIBUTORS	XI
FOREWORD	XIII
INTRODUCTION	XVII
1 PSYCHOTHERAPY AND THE SINGLE SYNAPSE: THE IMPACT OF PSYCHIATRIC THOUGHT ON NEUROBIOLOGIC RESEARCH	1	(26)
Eric R. Kandel, M.D.
With commentary by Judith L. Rapoport, M.D.
2 A NEW INTELLECTUAL FRAMEWORK FOR PSYCHIATRY	27	(32)
Eric R. Kandel, M.D.
With commentary by Thomas R. Insel, M.D.
3 BIOLOGY AND THE FUTURE OF PSYCHOANALYSIS: A NEW INTELLECTUAL FRAMEWORK FOR PSYCHIATRY REVISITED	59	(48)
Eric R. Kandel, M.D.
With commentary by Arnold M. Cooper, M.D.
4 FROM METAPSYCHOLOGY TO MOLECULAR BIOLOGY: EXPLORATIONS INTO THE NATURE OF ANXIETY	107	(50)
Eric R. Kandel, M.D.
With commentaries by Donald F. Klein, M.D., and Joseph LeDoux, Ph.D.
5 NEUROBIOLOGY AND MOLECULAR BIOLOGY: THE SECOND ENCOUNTER	157	(42)
Eric R. Kandel, M.D.
With commentary by Eric J. Nestler, M.D., Ph.D.
6 NEURAL SCIENCE: A CENTURY OF PROGRESS AND THE MYSTERIES THAT REMAIN	199	(138)
Thomas D. Albright, Ph.D.
Thomas M. Jessell, Ph.D.
Eric R. Kandel, M.D.
Michael I. Posner, Ph.D.
With commentary by Steven E. Hyman, M.D.
7 THE MOLECULAR BIOLOGY OF MEMORY STORAGE: A DIALOGUE BETWEEN GENES AND SYNAPSES	337	(36)
Eric R. Kandel, M.D.
With commentary by Charles F. Zorumshi, M.D.
8 GENES, BRAINS, AND SELF-UNDERSTANDING: BIOLOGY'S ASPIRATIONS FOR A NEW HUMANISM	373	(12)
Eric R. Kandel, M.D.
With commentary by John M. Oldham, M.D.
AFTERWORD	385	(4)
INDEX	389