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9781853176012

Psychopharmacology of Antipsychotics

by ;
  • ISBN13:

    9781853176012

  • ISBN10:

    185317601X

  • Edition: 1st
  • Format: Paperback
  • Copyright: 1999-06-17
  • Publisher: CRC Press

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Supplemental Materials

What is included with this book?

Summary

Another distinctive handbook, this covers all the classes of antipsychotics currently available and clearly explains the complex pharmacological mechanisms involved in the actions of the different classes.

Table of Contents

Introduction
Four Key Neurotransmitter Systems: Mediators of antipsychotic psychopharmacology
Dopamine
Serotonin
Serotonin-dopamine interactions
Acetylcholine
Dopamine-acetylcholine interactions
Glutamate
Symptoms and Pathophysiology of Schizophrenia
Positive symptoms
Dopamine hypothesis of positive symptoms
Negative symptoms
Cognitive symptoms
Aggressive symptoms
Mood and anxiety symptoms
Neurodevelopmental hypotheses
Neurodegenerative hypotheses
Conventional Antipsychotics: the classical neuroleptics
Nonselective D2
Antihistamine, anticholinergic, α1-antagonist
Dopamine-acetylcholine imbalance
Tardive dyskinesia
Phenothiazines
Thioxanthines
Butyrophenones
Heterocyclics
Atypical Antipsychotics and Serotonin-Dopamine Antagonism
List of agents, new and old
Properties: improved EPS (extrapyramidal symptoms), lower prolactin, improved negative symptoms
Serotonin-dopamine antagonism in the striatum
PET (positron emission tomography) scans
Serotonin-dopamine antagonism in the pituitary
Serotonin-dopamine antagonism in the cortex
Beyond the SDA (serotonin-dopamine antagonism) Concept: how individual atypical antipsychotics differ
Clozapine
Risperidone
Olanzapine
Quetiapine
Sertindole
Ziprasidone
Loxapine
Zotepine
Differential pharmacologies
Clinical pearls
Dosage tips
The Cytochrome P450 (CYP) System and Pharmacokinetic Considerations for Atypical Antipsychotics
Preventing unwanted pharmacokinetic interactions
Role of 1A2
Role of CYP 2D6
Role of CYP 2C
Role of CYP 3A4
Pharmacokinetic pearls
Antipsychotic summary
Treatment of positive symptoms
Treatment of negative symptoms
Treatment of cognition, hostility, aggression and mood
Clinical trials vs. clinical practice
Managing inadequate treatment responses
References
Index

Supplemental Materials

What is included with this book?

The New copy of this book will include any supplemental materials advertised. Please check the title of the book to determine if it should include any access cards, study guides, lab manuals, CDs, etc.

The Used, Rental and eBook copies of this book are not guaranteed to include any supplemental materials. Typically, only the book itself is included. This is true even if the title states it includes any access cards, study guides, lab manuals, CDs, etc.

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