Quality in Laboratory Hemostasis and Thrombosis

by Editor: Steve Kitchen; Editor: John Olson; Editor: Eric Preston

• ISBN13: 9781444303582
• ISBN10: 1444303589
• Format: eBook
• Copyright: 2009-01-01
• Publisher: Wiley-Blackwell

Summary

"Over the last decades, major progress has been made in quality assurance of hemostatic laboratory assays. This book will be an indispensable part of every hemostasis laboratory, where, given its hands-on nature, it will rarely sit to get dusty on the shelves." - Frits R. Rosendaal, Leiden University Medical CenterThe hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Its role in the monitoring traditional anticoagulant therapy as well as therapy using new anticoagulants presents new challenges to the laboratory. Quality in Laboratory Hemostasis and Thrombosis not only addresses these important issues, but also covers international guidelines for testing, the development of international standard materials, management of hemostasis testing from the laboratory to the point of care as well as molecular genetic testing.Designed as a guide for all those working in hemostasis laboratories, this book details a quality program that, when put into place, will help to improve standards in testing. All of the authors are internationally recognised for their work in hemostasis and thrombosis. Using their experience, they provide information on standards, equipment and methods that will guide the development of a quality program to support all activities in the hemostasis laboratory.

Table of Contents

Foreword, Frits

General Quality Planning in the Hemostasis Laboratory

Hemostasis Test Validation, Performance and Reference Intervals: International Recommendations and Guidelines

International Standards in Hemostasis

Sample Integrity and Preanalytical Variables

Internal Quality Control in the Hemostasis Laboratory

External Quality Assessment in Hemostasis: Its Importance and Significance

Initial Evaluation of Hemostasis: Reagent and Method Selection

Point-of-Care Testing in Hemostasis

Assay of Factor VIII and Other Clotting Factors

Application of Molecular Genetics to the Investigation of Inherited Bleeding Disorders

Standardisation of D-dimer Testing, Guido Reber

Diagnostic Assessment of Platelet Function

Laboratory Evaluation of von Willebrand Disease: Phenotypic Analysis

Laboratory Analysis of von Willebrand Disease: Molecular Analysis

Dilemmas in Heritable Thrombophilia Testing

Evaluation of Antiphospholipid Antibodies

Monitoring Heparin Therapy

Monitoring Oral Anticoagulant Therapy

Monitoring New Anticoagulants

Detecting and Quantifying Functional Inhibitors in Hemostasis

Table of Contents provided by Publisher. All Rights Reserved.