Quinolone Antimicrobial Agents

by Hooper, David C.; Rubinstein, Ethan

• ISBN13: 9781555812317
• ISBN10: 1555812317
• Edition: 3rd
• Format: Hardcover
• Copyright: 2003-08-01
• Publisher: Amer Society for Microbiology

Summary

Harvard Medical School, Boston, MA. Discusses the mechanisms, spectrum of activity, resistance, pharmacology, and clinical aspects of quinolone antimicrobial agents. Covers the adverse effects and bacterial resistance based on latest data. For clinical microbiologists. Previous edition: c1993. DNLM: Anti-Infective Agents, Quinolone--therapeutic use.

Table of Contents

Contributors	p. vii
Preface	p. xi
Introduction	p. xiii
Mechanisms and Spectrum of Antibacterial Activity and Resistance
Structure-Activity Relationships of the Quinolone Antibacterials in the New Millennium: Some Things Change and Some Do Not	p. 3
Mechanisms of Quinolone Action	p. 19
Mechanisms of Quinolone Resistance	p. 41
Quinolones and Eukaryotic Topoisomerases	p. 69
Activity In Vitro of the Quinolones	p. 91
Pharmacology
Pharmacokinetics of Fluoroquinolones	p. 115
Drug-Drug Interactions	p. 133
Pharmacodynamics of Quinolone Antimicrobial Agents	p. 147
Clinical Applications
Treatment of Urinary Tract Infections	p. 159
Use of Quinolones for Treatment of Sexually Transmitted Diseases	p. 171
Treatment and Prophylaxis of Gastroenteritis	p. 193
Treatment of Intra-Abdominal Infections	p. 217
Treatment of Community-Acquired Respiratory Tract Infections	p. 227
Treatment of Infections of the Ears, Nose, and Throat and Nasal Carriage	p. 245
Treatment of Osteomyelitis and Septic Arthritis	p. 251
Treatment of Experimental and Human Bacterial Endocarditis with Quinolone Antimicrobial Agents	p. 259
Treatment of Bacterial Meningitis and Other Central Nervous Systems Infections	p. 275
Treatment of Eye Infections	p. 291
Treatment of Skin and Soft Tissue Infections	p. 311
Treatment of Intracellular Infections	p. 323
Fluoroquinolones in Intensive Care Unit Infections	p. 337
Quinolones in Pediatrics	p. 343
Quinolone Resistance and Its Clinical Relevance	p. 355
Veterinary Use of Quinolones and Impact on Human Infections	p. 387
Adverse and Other Effects
Adverse Effects	p. 407
QT Prolongation with Quinolone Antimicrobial Agents	p. 421
Effects on Connective Tissue Structures	p. 441
Phototoxicity Due to Fluoroquinolones	p. 451
Central Nervous System Toxicity	p. 461
Effects of Quinolones on the Immune System	p. 467
Index	p. 475
Table of Contents provided by Rittenhouse. All Rights Reserved.