The Radiation Biology of the Vascular Endothelium

by Rubin; David B.

• ISBN13: 9780849348402
• ISBN10: 0849348404
• Format: Hardcover
• Copyright: 1997-12-29
• Publisher: CRC Press

Summary

Endothelial cells are early targets of radiation injury. Because these cells are tissues easily damaged by radiation, if we can understand the causes of radiation injury, then normal cells can be well protected and tumors can be destroyed. The Radiation Biology of the Vascular Endothelium brings together expert reviews on the biology and radiobiology of the vasculature, with emphasis on the endothelial cell component of blood vessels.The book covers both the basic aspects of endothelial cell biology and the practical consequences of this for the oncologist, with special reference to the radiation oncologist. After reading The Radiation Biology of the Vascular Endothelium, no clinical or experimental oncologist should be able to ignore the intimate relationship between tumor and normal tissue cells and endothelial cells that form the barrier to, and are the bearers of, essential nutrient supplies.

Table of Contents

Chapter 1 The Endothelial Cell Is a Unique Target of Radiation: An Overview	1	(12)
Luis F. Fajardo L-G
Chapter 2 The Histopathology of Irradiated Endothelium	13	(26)
David B. Rubin
Melvin L. Griem
Chapter 3 Functional Measures of Endothelial Integrity and Pharmacologic Modification of Radiation Injury	39	(26)
Michael M. Graham
Lanell M. Peterson
Chapter 4 Antioxidant Defenses and the Irradiated Endothelium	65	(26)
David B. Rubin
Elizabeth A. Drab-Weiss
Ed Robert Blazek
Chapter 5 Protein Synthesis in Irradiated Endothelial Cells	91	(10)
Eliot M. Rosen
Itzhak D. Goldberg
Chapter 6 Signaling in the Radiation Response of Endothelial Cells	101	(28)
Adriana Haimovitz-Friedman
Zvi Fuks
Chapter 7 Effect of Ionizing Radiation on Endothelial Cell Plasma Membrane Processes	129	(18)
Lester Kwock
A. William Blackstock
Mitchell Friedman
Chapter 8 Inflammatory Cytokines, Radiation, and Endothelial Gene Products: A Common Role for Reactive Oxygen Intermediates	147	(14)
Cliff Murray
Chapter 9 Extracellular Matrix Regulates Endothelial Cell Morphology, Receptor Expression, and Response to Low-Dose Radiation	161	(24)
James M. Onoda
Seema S. Kantak
Clement A. Diglio
Chapter 10 Endothelial-Oriented Strategies to Spare Normal Tissues	185	(24)
William F. Ward
Agostino Molteni
Chung-hsin Ts'ao
Chapter 11 Tumor Bed Phenomenon: Effect on Tumor Progression and Therapy	209	(22)
Luka Milas
Mira Milas
Chapter 12 Photodynamic Therapy and Endothelial Cells	231	(16)
David C. West
James V. Moore
Index	247